Results 61 to 70 of about 91,154 (289)

Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. [PDF]

open access: yes, 2019
TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a ...
Han, Tina W   +4 more
core   +2 more sources

Protocol: optimised electrophyiological analysis of intact guard cells from arabidopsis [PDF]

open access: yes, 2012
Genetic resources available for Arabidopsis thaliana make this species particularly attractive as a model for molecular genetic studies of guard cell homeostasis, transport and signalling, but this facility is not matched by accessible tools for ...
Blatt, M.R.   +4 more
core   +3 more sources

Identification of Bax–voltage‐dependent anion channel 1 complexes in digitonin‐solubilized cerebellar granule neurons [PDF]

open access: yesJournal of Neurochemistry, 2011
J. Neurochem. (2011) 119, 1137–1150.AbstractMitochondrial outer membrane Bax oligomers are critical for cytochrome c release, but the role of resident mitochondrial proteins in this process remains unclear. Membrane‐associated Bax has primarily been studied using 3‐[(3‐cholamidopropyl)dimethylammonio]‐1‐propanesulfonate (CHAPS) as the solubilizing ...
Dennis B, Huckabee, Mika B, Jekabsons
openaire   +2 more sources

VDAC1 oligomerization may enhance DDP‐induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage

open access: yesFEBS Open Bio, 2022
Cisplatin (DDP)‐based chemotherapy is a preferred treatment for a broad spectrum of cancers, but the precise mechanisms of its hepatotoxicity are not yet clear.
Xueqin Zhu   +6 more
doaj   +1 more source

Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. [PDF]

open access: yes, 2016
Electrical membrane properties of skeletal muscle fibers have been thoroughly studied over the last five to six decades. This has shown that muscle fibers from a wide range of species, including fish, amphibians, reptiles, birds, and mammals, are all ...
Chen, Tsung-Yu   +4 more
core   +1 more source

Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background The cardiac microvascular system ischemia/reperfusion injury following percutaneous coronary intervention is a clinical thorny problem. This study explores the mechanisms by which ischemia/reperfusion injury induces cardiac microcirculation ...
Hao Zhou   +8 more
doaj   +1 more source

DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1

open access: yesMolecular Medicine, 2023
Background Mitochondrial metabolism has been proposed as an attractive target for breast cancer therapy. The discovery of new mechanisms underlying mitochondrial dysfunction will facilitate the development of new metabolic inhibitors to improve the ...
Ling Huang   +4 more
doaj   +1 more source

Theory of membrane capacitive deionization including the effect of the electrode pore space [PDF]

open access: yes, 2011
Membrane capacitive deionization (MCDI) is a technology for water desalination based on applying an electrical field between two oppositely placed porous electrodes.
Biesheuvel, P.M.   +3 more
core   +2 more sources

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

open access: yes, 2013
Important modulatory roles have been attributed to presynaptic NMDA receptors (NMDARs) located on cerebellar interneuron terminals. Evidence supporting a presynaptic location includes an increase in the frequency of mini events following the application ...
Benton, DCH   +4 more
core   +1 more source

Mitochondrial Proteomics Approach Reveals Voltage-Dependent Anion Channel 1 (VDAC1) as a Potential Biomarker of Gastric Cancer

open access: yesCellular Physiology and Biochemistry, 2015
Background/Aims: Gastric cancer (GC) remains the second leading cause of cancer-related deaths in the world. Successful early cancer detection is hampered by lack of highly sensitive and specific biomarkers.
Wen Gao   +7 more
doaj   +1 more source

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