Results 11 to 20 of about 95,928 (309)
Cholesterol influences voltage-gated calcium channels and BK-type potassium channels in auditory hair cells. [PDF]
PLoS ONE, 2011 The influence of membrane cholesterol content on a variety of ion channel conductances in numerous cell models has been shown, but studies exploring its role in auditory hair cell physiology are scarce.
Erin K Purcell +3 more
doaj +1 more source
Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling
eLife, 2020 Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer +5 more
doaj +1 more source
Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. [PDF]
PLoS ONE, 2013 Calcium-activated potassium channels of the KCa1.1 class are known to regulate repolarization of action potential discharge through a molecular association with high voltage-activated calcium channels.
Renata Rehak +5 more
doaj +1 more source
Inactivation of CACNA1H induces cell apoptosis by initiating endoplasmic reticulum stress in glioma
Translational Neuroscience, 2023 Ca2+ channels are abnormally expressed in various tumor cells and are involved in the progression of human glioma. Here, we explored the role of a calcium channel, voltage-dependent, T-type, alpha 1H subunit (CACNA1H), which encodes T-type Ca2+ channel ...
Liu Sheng +3 more
doaj +1 more source
eLife, 2016 The auxiliary α2δ subunits of voltage-gated calcium channels are extracellular membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptides α2 and δ.
Ivan Kadurin +11 more
doaj +1 more source
A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels
Molecular Brain, 2021 A novel missense mutation in the CACNA1A gene that encodes the pore forming α1 subunit of the CaV2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia.
Eder Gambeta +4 more
doaj +1 more source
Frontiers in Microbiology, 2016 The oomycete vegetable pathogen Phytophthora capsici causes significant losses of important vegetable crops worldwide. Calcium and other plant nutrients have been used in disease management of oomycete pathogens.
Peiqing Liu +7 more
doaj +1 more source
Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores. [PDF]
PLoS ONE, 2017 Decreased leptin-induced endothelium-dependent vasodilation has been reported in spontaneously hypertensive rats (SHR). Here, we report leptin-induced vasoconstriction in endothelium-denuded pulmonary artery and thoracic aorta from SHR and sought to ...
Samantha Gomart +10 more
doaj +1 more source
Frontiers in Physiology, 2018 In this study, we report a unique dominantly inherited disorganized supernumerary cusp and single root phenotype presented by 11 affected individuals belonging to 5 north-eastern Thai families.
Virginie Laugel-Haushalter +19 more
doaj +1 more source
Molecular Pharmacology of Voltage-Dependent Calcium Channels
Japanese Journal of Pharmacology, 1996 Voltage-dependent Ca2+ channels serve as the only link to transduce membrane depolarization into cellular Ca(2+)-dependent reactions. A wide variety of chemical substances that have the ability to modulate Ca2+ channels have been demonstrated both for their clinic utility and for importance in elucidating the molecular basis of various biological ...
Y, Mori +6 more
openaire +3 more sources