Results 31 to 40 of about 402,017 (293)

Lipid ion channels and the role of proteins [PDF]

, 2013
Synthetic lipid membranes in the absence of proteins can display quantized conduction events for ions that are virtually indistinguishable from those of protein channel. By indistinguishable we mean that one cannot decide based on the current trace alone
Heimburg, Thomas, Mosgaard, Lars D.
core   +1 more source

Voltage-Gated Potassium Channel Kv1.3 as a Target in Therapy of Cancer

Frontiers in Oncology, 2019
Voltage-gated potassium channel Kv1.3 is an integral membrane protein, which is selectively permeable for potassium ions and is activated upon a change of membrane potential.
A. Teisseyre, Anna Palko-Labuz, K. Środa-Pomianek, K. Michalak   +3 more
semanticscholar   +1 more source

Ion channel gating: a first passage time analysis of the Kramers type [PDF]

, 2001
The opening rate of voltage-gated potassium ion channels exhibits a characteristic, knee-like turnover where the common exponential voltage-dependence changes suddenly into a linear one.
Blatz, De Gennes, Dewey, Hodgkin, Igor Goychuk, Levitt, Läuger, Mainen, Mercik, Peter Hänggi, Reimann, Ring, Sigg   +12 more
core   +4 more sources

SGK3 Sensitivity of Voltage Gated K+ Channel Kv1.5 (KCNA5)

Cellular Physiology and Biochemistry, 2016
Background: The serum & glucocorticoid inducible kinase isoform SGK3 is a powerful regulator of several transporters, ion channels and the Na+/K+ ATPase.
Musaab Ahmed, Myriam Fezai, Nestor L. Uzcategui, Zohreh Hosseinzadeh, Florian Lang   +4 more
doaj   +1 more source

Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]

, 2014
The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat, Beltran-Alvarez, Pedro, Brugada, Ramon, Chiva, Cristina, Chiva, Critina, Pagans, Sara, Perez-Serra, Alexandra, Perez-Villa, Felix, Pérez-Serra, Alexandra, Pérez-Villa, Félix, Sabido, Eduard, Sabidó, Eduard, Schulte, Uwe, Tarradas, Anna   +13 more
core   +1 more source

Tarantula Toxin ProTx-I Differentiates Between Human T-type Voltage-Gated Ca2+ Channels Cav3.1 and Cav3.2

Journal of Pharmacological Sciences, 2010
ProTx-I peptide, a venom toxin of the tarantula Thrixopelma pruriens, has been reported to interact with voltage-gated ion channels. ProTx-I reduced Ba2+ currents through recombinant human T-type voltage-gated Ca2+ channels, Cav3.1 (hCav3.1), with ...
Tsuyako Ohkubo, Jun Yamazaki, Kenji Kitamura   +2 more
doaj   +1 more source

Inhibition by Pregnenolone Sulphate, a Metabolite of the Neurosteroid Pregnenolone, of Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes

Journal of Pharmacological Sciences, 2012
Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Nav,
Takafumi Horishita, Susumu Ueno, Nobuyuki Yanagihara, Yuka Sudo, Yasuhito Uezono, Dan Okura, Takeyoshi Sata   +6 more
doaj   +1 more source

Voltage-dependent gating in a "voltage sensor-less" ion channel.

PLoS Biology, 2010
The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity.
Harley T Kurata, Markus Rapedius, Marc J Kleinman, Thomas Baukrowitz, Colin G Nichols   +4 more
doaj   +1 more source

Beyond CBD: Inhibitory effects of lesser studied phytocannabinoids on human voltage-gated sodium channels

Frontiers in Physiology, 2023
Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in the treatment of epilepsy.
Carol J. Milligan, Lyndsey L. Anderson, Lyndsey L. Anderson, Lyndsey L. Anderson, Iain S. McGregor, Iain S. McGregor, Iain S. McGregor, Jonathon C. Arnold, Jonathon C. Arnold, Jonathon C. Arnold, Steven Petrou, Steven Petrou   +11 more
doaj   +1 more source

Voltage sensing in ion channels: Mesoscale simulations of biological devices [PDF]

, 2012
Electrical signaling via voltage-gated ion channels depends upon the function of a voltage sensor (VS), identified with the S1-S4 domain in voltage-gated K+ channels.
A. Hodgkin, A. Hodgkin, Alexander Peyser, B. Hille, Wolfgang Nonner   +4 more
core   +2 more sources