Results 11 to 20 of about 238,298 (223)
Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus [PDF]
eLife, 2014 Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters ...
Paul G DeCaen +4 more
doaj +4 more sources
CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain. [PDF]
Neuronal Signal, 2018 Neuropathic pain represents a significant and mounting burden on patients and society at large. Management of neuropathic pain, however, is both intricate and challenging, exacerbated by the limited quantity and quality of clinically available treatments.
Chew LA, Khanna R.
europepmc +2 more sources
Dynamic all-optical drug screening on cardiac voltage-gated ion channels. [PDF]
Sci Rep, 2018 Voltage-gated ion channels (VGCs) are prime targets for the pharmaceutical industry, but drug profiling on VGCs is challenging, since drug interactions are confined to specific conformational channel states mediated by changes in transmembrane potential.
Streit J, Kleinlogel S.
europepmc +2 more sources
Voltage‐Gated Ion Channels: Structure, Pharmacology and Photopharmacology
ChemPhysChemAbstractVoltage‐gated ion channels are transmembrane proteins responsible for the generation and propagation of action potentials in excitable cells. Over the last decade, advancements have enabled the elucidation of crystal structures of ion channels.
Vito F. Palmisano +3 more
openaire +5 more sources
Voltage-gated ion channels in cancer cell proliferation. [PDF]
Cancers (Basel), 2015 Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions.
Rao VR, Perez-Neut M, Kaja S, Gentile S.
europepmc +2 more sources
High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE. [PDF]
PLoS One, 2017 Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel function, patch clamp electrophysiology is considered the gold standard by providing the ultimate ...
Li T +5 more
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels. [PDF]
Br J Pharmacol, 2015 The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands ( www.guidetopharmacology.org
Alexander SP +11 more
europepmc +2 more sources
Surface dynamics of voltage-gated ion channels. [PDF]
Channels (Austin), 2016 Neurons encode information in fast changes of the membrane potential, and thus electrical membrane properties are critically important for the integration and processing of synaptic inputs by a neuron. These electrical properties are largely determined by ion channels embedded in the membrane.
Heine M +4 more
europepmc +4 more sources
An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human Cav Channels [PDF]
Cell Reports, 2018 Summary: Voltage-gated ion channels (VGICs) are associated with hundreds of human diseases. To date, 3D structural models of human VGICs have not been reported.
Wilnelly Martinez-Ortiz +1 more
doaj +2 more sources
Voltage-Gated Ion Channels [PDF]
IEEE Transactions on Nanobioscience, 2005 Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
+7 more sources