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Spared but Not Silent: Ion Channel Plasticity in Uninjured Sensory Neurons in Neuropathic Pain. [PDF]
Int J Mol SciSpeidell A, Khanna R, Gomez K.
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On the opening of voltage-gated ion channels
Physiology and Behavior, 2007Voltage-gated ion channels are key players in fast neuronal signalling. Detailed knowledge about channel gating is essential for our understanding of channel function in general and of drug action of channels in particular. Despite a number of recent atomic channel structures, the opening of voltage-gated channels is the subject of heated debates. Here
Fredrik Elinder +2 more
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Voltage gating of ion channels
Quarterly Reviews of Biophysics, 1994Voltage-gated ion channels are membrane proteins that play a central role in the propagation and transduction of cellular signals (Hille, 1992). Calcium ions entering cells through voltage-gated calcium channels serve as the trigger for neurotransmitter release, muscle contraction, and the release of hormones. Voltage-gated sodium channels initiate the
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2008
How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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The kinetics of voltage-gated ion channels
Quarterly Reviews of Biophysics, 1994When Hodgkin & Huxley (1952) first embarked on the analysis of their voltageclamp data on the ionic currents in the squid giant axon, they hoped to be able to deduce a mechanism from it, but it soon became clear that the electrical data would by themselves yield only very general information about the class of system likely to be involved.
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Voltage Gated Ion Channels and Sleep
The Journal of Membrane BiologyIon channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or localization, can lead to irregular neuronal excitability and synaptic communication, which may manifest as various ...
Yan, Zhang +5 more
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Structure and Function of Voltage-Gated Ion Channels
Annual Review of Biochemistry, 1993The principal subunits of the voltage-gated Na+, Ca2+ and K+ channels are members of a related gene family and are functionally autonomous in voltage-dependent activation, ion conductance and inactivation. In this article, recent work locating the structural elements that are responsible for these three basic functions of the voltage-gated ion channels
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Structure and Modulation of Voltage‐Gated Ion Channels
Annals of the New York Academy of Sciences, 1991The depolarizing phase of the action potential in most excitable cells results from an initial increase in sodium permeability mediated by voltage-gated sodium channels followed by a more prolonged increase in calcium permeability mediated by voltage-gated calcium channels. Repolarization is then caused by activation of voltage-gated potassium channels.
W A, Catterall +3 more
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Voltage-Gated Ion Channels and Hereditary Disease
Physiological Reviews, 1999By the introduction of technological advancement in methods of structural analysis, electronics, and recombinant DNA techniques, research in physiology has become molecular. Additionally, focus of interest has been moving away from classical physiology to become increasingly centered on mechanisms of disease.
F, Lehmann-Horn, K, Jurkat-Rott
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Molecular pathophysiology of voltage-gated ion channels
1996In addition to the clarification of the pathology of a whole group of hereditary diseases, the study of the consequences of these mutations at the levels of the whole system (patient), organ and cells (excised muscle specimens), and of the channel proteins has taught us that our current opinions on channel structure-function relations are far from ...
F, Lehmann-Horn, R, Rüdel
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