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The moving parts of voltage-gated ion channels
Quarterly Reviews of Biophysics, 1998Ion channels, like many other proteins, have moving parts that perform useful functions. The channel proteins contain an aqueous, ion-selective pore that crosses the plasma membrane, and they use a number of distinct ‘gating’ mechanisms to open and close this pore in response to biological stimuli such as the binding of a ligand or a change in the ...
G. Yellen
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Structural biology and molecular pharmacology of voltage-gated ion channels
Nature Reviews Molecular Cell BiologyXiaojing Pan, Nieng Yan
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Journal of Medicinal Chemistry, 2020
Ion channels have been characterized as promising drug targets for treatment of numerous human diseases. Functions of ion channels can be fine-tuned by allosteric modulators, which interact with channels and modulate their activities by binding to sites ...
Yanyun Zhang, Ke Wang, Zhiyi Yu
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Ion channels have been characterized as promising drug targets for treatment of numerous human diseases. Functions of ion channels can be fine-tuned by allosteric modulators, which interact with channels and modulate their activities by binding to sites ...
Yanyun Zhang, Ke Wang, Zhiyi Yu
semanticscholar +1 more source
Voltage gating of ion channels
Quarterly Reviews of Biophysics, 1994Voltage-gated ion channels are membrane proteins that play a central role in the propagation and transduction of cellular signals (Hille, 1992). Calcium ions entering cells through voltage-gated calcium channels serve as the trigger for neurotransmitter release, muscle contraction, and the release of hormones. Voltage-gated sodium channels initiate the
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2008
How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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The kinetics of voltage-gated ion channels
Quarterly Reviews of Biophysics, 1994When Hodgkin & Huxley (1952) first embarked on the analysis of their voltageclamp data on the ionic currents in the squid giant axon, they hoped to be able to deduce a mechanism from it, but it soon became clear that the electrical data would by themselves yield only very general information about the class of system likely to be involved.
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Voltage-gated ion channels and gating modifier toxins.
Toxicon, 2007Voltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent neurotoxins.
W. Catterall +5 more
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Voltage Gated Ion Channels and Sleep
The Journal of Membrane BiologyIon channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or localization, can lead to irregular neuronal excitability and synaptic communication, which may manifest as various ...
Yan, Zhang +5 more
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Structure and Modulation of Voltage‐Gated Ion Channels
Annals of the New York Academy of Sciences, 1991The depolarizing phase of the action potential in most excitable cells results from an initial increase in sodium permeability mediated by voltage-gated sodium channels followed by a more prolonged increase in calcium permeability mediated by voltage-gated calcium channels. Repolarization is then caused by activation of voltage-gated potassium channels.
W A, Catterall +3 more
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Molecular pathophysiology of voltage-gated ion channels
1996In addition to the clarification of the pathology of a whole group of hereditary diseases, the study of the consequences of these mutations at the levels of the whole system (patient), organ and cells (excised muscle specimens), and of the channel proteins has taught us that our current opinions on channel structure-function relations are far from ...
F, Lehmann-Horn, R, Rüdel
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