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Diseases caused by voltage-gated ion channels
Molecular Aspects of Medicine, 1997Ion channels regulate the transfer of ions between the outer and the inner surface of the cell membrane. The opening of ion channels may be triggered by the binding of a ligand or variations in the membrane potential. Voltage-gated ion channels are an important class of such channels, that are involved in the generation and propagation of action ...
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Structure and Function of Voltage-Gated Ion Channels
Naturwissenschaften, 1998Voltage-gated ion channels are key molecules for the generation of electrical signals in cells. They are integral membrane proteins which are activated by a depolarized membrane potential resulting in a conformational change, allowing ions to permeate.
H, Terlau, W, Stühmer
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2011
Both voltage-gated and ligand-gated ion channels are large protein molecules, as is the sodium pump Na,K-ATPase. In recent years the primary structure of a number of them has been determined, and by combining this information with the biophysical evidence, major advances have been made in our understanding of how they work at the molecular and ...
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Both voltage-gated and ligand-gated ion channels are large protein molecules, as is the sodium pump Na,K-ATPase. In recent years the primary structure of a number of them has been determined, and by combining this information with the biophysical evidence, major advances have been made in our understanding of how they work at the molecular and ...
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The moving parts of voltage-gated ion channels
Quarterly Reviews of Biophysics, 1998Ion channels, like many other proteins, have moving parts that perform useful functions. The channel proteins contain an aqueous, ion-selective pore that crosses the plasma membrane, and they use a number of distinct ‘gating’ mechanisms to open and close this pore in response to biological stimuli such as the binding of a ligand or a change in the ...
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HTS approaches to voltage-gated ion channel drug discovery
Drug Discovery Today, 1998Brian Cox
exaly
Calmodulin regulation (calmodulation) of voltage-gated calcium channels
Journal of General Physiology, 2014Manu Ben-Johny, David T Yue
exaly