Results 1 to 10 of about 101,918 (291)

Voltage-gated potassium channels and genetic epilepsy. [PDF]

Front Neurol
Recent advances in exome and targeted sequencing have significantly improved the aetiological diagnosis of epilepsy, revealing an increasing number of epilepsy-related pathogenic genes.
Zheng Y, Chen J.
europepmc   +4 more sources

KCNQs: Ligand- and Voltage-Gated Potassium Channels. [PDF]

Front Physiol, 2020
Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens.
Abbott GW.
europepmc   +7 more sources

Direct neurotransmitter activation of voltage-gated potassium channels. [PDF]

Nat Commun, 2018
M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine.
Manville RW, Papanikolaou M, Abbott GW.
europepmc   +7 more sources

Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders. [PDF]

Front Cell Neurosci
Voltage-gated potassium channels are a widely distributed subgroup of potassium channels responsible for the efflux of potassium in the repolarisation of the cell membrane, and hence contribute to the latency and propagation of action potentials. As they
Faulkner IE, Pajak RZ, Harte MK, Glazier JD, Hager R.   +4 more
europepmc   +2 more sources

Voltage-Gated Potassium Channels as Regulators of Cell Death. [PDF]

Front Cell Dev Biol, 2020
Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume
Bachmann M, Li W, Edwards MJ, Ahmad SA, Patel S, Szabo I, Gulbins E.   +6 more
europepmc   +2 more sources

Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels. [PDF]

Pharmaceuticals (Basel)
Background/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
McCoy MT, Ladenheim B, Cadet JL, Daiwile AP.   +3 more
europepmc   +2 more sources

Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels. [PDF]

Front Cell Neurosci
Voltage gated potassium channels can be composed of either four identical, or different, pore-forming protein subunits. While the voltage gated channels with identical subunits have been extensively studied both physiologically and mathematically, those ...
McGahan K, Keener J.
europepmc   +2 more sources

Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases. [PDF]

Front Cell Neurosci
Voltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca2+ flow through the membrane. Among all ion channels, the key regulators of neuronal excitability are the voltage-
Urrutia J, Arrizabalaga-Iriondo A, Sanchez-Del-Rey A, Martinez-Ibargüen A, Gallego M, Casis O, Revuelta M.   +6 more
europepmc   +2 more sources

Developmental Expression of Kv Potassium Channels at the Axon Initial Segment of Cultured Hippocampal Neurons [PDF]

PLoS ONE, 2012
Axonal outgrowth and the formation of the axon initial segment (AIS) are early events in the acquisition of neuronal polarity. The AIS is characterized by a high concentration of voltage-dependent sodium and potassium channels.
A Duflocq, A Duflocq, A Korngreen, A Lorincz, A Triller, A Van Wart, AH Song, Alberto Muñoz, AS Hill, AV Weigel, B Winckler, BD Clark, BP Bean, C Nakada, CD Paspalas, CM Colbert, CS Jensen, D Guan, D Sanchez-Ponce, D Sanchez-Ponce, D Zhou, DA Brown, DE Antonucci, Diana Sánchez-Ponce, DJ Surmeier, DP Mohapatra, E Bocksteins, E Glasscock, E Kim, EC Cooper, EM Goldberg, F Klinger, FH Yu, G Banker, G Lemaillet, G Stuart, GA Gutman, GA Gutman, GJ Stuart, H Misonou, H Misonou, H Misonou, H Murakoshi, HB Rasmussen, HJ Chung, J Du, J Du, J Johnston, J Johnston, J Kang, Javier DeFelipe, JJ Devaux, JJ Garrido, JM Bekkers, JQ Davis, JR Schwarz, JS Trimmer, Juan José Garrido, K Heusser, K Vervaeke, KG Chandy, KJ Bender, KL Hedstrom, KL Hedstrom, KL Hedstrom, KM O’Connell, LH Eunson, LM Palmer, LN Manganas, M Maletic-Savatic, M Royeck, M Tapia, MC Inda, MH Kole, MH Kole, MJ Berridge, MM Shah, MM Tamkun, MN Rasband, MN Rasband, N Burkarth, PD Sarmiere, PM Hwang, R Nashmi, RH Scannevin, SA Buffington, SM Jenkins, ST Lim, Stuart E. Dryer, T Boiko, T Boiko, T Nakata, TJ Jentsch, W Hu, WA Kaufmann, WA Kaufmann, Y Kihira, Y Li, Y Ogawa, Y Ogawa, Y Shu, Y Yu, Y Yu, Z Pan   +103 more
core   +6 more sources

The role of axonal voltage-gated potassium channels in tDCS

Brain Stimulation, 2022
Background: Transcranial direct current stimulation (tDCS) is a non-invasive sub-threshold stimulation, widely accepted for its amelioration of distinct neuropsychiatric disorders.
Sreerag Othayoth Vasu, Hanoch Kaphzan
doaj   +1 more source