Voltage-gated potassium channels and genetic epilepsy [PDF]
Frontiers in NeurologyRecent advances in exome and targeted sequencing have significantly improved the aetiological diagnosis of epilepsy, revealing an increasing number of epilepsy-related pathogenic genes.
Yiting Zheng, Jing Chen
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KCNQs: Ligand- and Voltage-Gated Potassium Channels [PDF]
Frontiers in Physiology, 2020 Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a broad range of excitable and non-excitable cell types and are found in organisms ranging from Hydra vulgaris to Homo sapiens.
Geoffrey W. Abbott
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Direct neurotransmitter activation of voltage-gated potassium channels [PDF]
Nature Communications, 2018 M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine.
Rían W. Manville +2 more
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VKCDB: Voltage-gated potassium channel database [PDF]
BMC Bioinformatics, 2004 Background The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based component of the membrane potential and are thus central to many critical ...
Gallin Warren J, Li Bin
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Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders [PDF]
Frontiers in Cellular NeuroscienceVoltage-gated potassium channels are a widely distributed subgroup of potassium channels responsible for the efflux of potassium in the repolarisation of the cell membrane, and hence contribute to the latency and propagation of action potentials. As they
Isabel E. Faulkner +4 more
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Voltage-Gated Potassium Channels as Regulators of Cell Death [PDF]
Frontiers in Cell and Developmental Biology, 2020 Ion channels allow the flux of specific ions across biological membranes, thereby determining ion homeostasis within the cells. Voltage-gated potassium-selective ion channels crucially contribute to the setting of the plasma membrane potential, to volume
Magdalena Bachmann +9 more
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Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels [PDF]
PharmaceuticalsBackground/Objectives: Potassium (K+) channels are essential transmembrane proteins that regulate ion flow, playing a critical role in regulating action potentials and neuronal transmission.
Michael T. McCoy +3 more
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Voltage-Gated Potassium Channels Beyond the Action Potential. [PDF]
Bioelectricity, 2022 Bioelectricity goes far beyond electrical signaling in the nervous system, but this was initially not obvious for me. This article describes the journey from studying the biophysics of ion channels in classical electrically excitable tissues to focusing on the pathogenic roles of the Kv10.1 potassium channel in cancers.
Pardo LA.
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Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons. [PDF]
PLoS ONE, 2012 Axonal outgrowth and the formation of the axon initial segment (AIS) are early events in the acquisition of neuronal polarity. The AIS is characterized by a high concentration of voltage-dependent sodium and potassium channels.
Diana Sánchez-Ponce +3 more
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Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels [PDF]
Frontiers in Cellular NeuroscienceVoltage gated potassium channels can be composed of either four identical, or different, pore-forming protein subunits. While the voltage gated channels with identical subunits have been extensively studied both physiologically and mathematically, those ...
Kees McGahan, James Keener
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