Results 21 to 30 of about 101,918 (291)

Oxidative Modulation of Voltage-Gated Potassium Channels [PDF]

open access: yesAntioxidants & Redox Signaling, 2014
Voltage-gated K+ channels are a large family of K+-selective ion channel protein complexes that open on membrane depolarization. These K+ channels are expressed in diverse tissues and their function is vital for numerous physiological processes, in particular of neurons and muscle cells.
Nirakar, Sahoo   +2 more
openaire   +2 more sources

Lipid ion channels and the role of proteins [PDF]

open access: yes, 2013
Synthetic lipid membranes in the absence of proteins can display quantized conduction events for ions that are virtually indistinguishable from those of protein channel. By indistinguishable we mean that one cannot decide based on the current trace alone
Heimburg, Thomas, Mosgaard, Lars D.
core   +1 more source

A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels

open access: yesMarine Drugs, 2022
Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior   +5 more
doaj   +1 more source

Ion channel gating: a first passage time analysis of the Kramers type [PDF]

open access: yes, 2001
The opening rate of voltage-gated potassium ion channels exhibits a characteristic, knee-like turnover where the common exponential voltage-dependence changes suddenly into a linear one.
Blatz   +12 more
core   +4 more sources

MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

open access: yesNature Communications, 2017
Dysregulation of voltage gated potassium channels is a feature of neuropathic pain. Here in a rat model the authors identify the microRNA cluster miR-17-92 as a regulator of voltage gated potassium channels in the dorsal root ganglion neurons.
Atsushi Sakai   +7 more
doaj   +1 more source

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

open access: yesToxins, 2016
The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez   +5 more
doaj   +1 more source

Photochromic Blockers of Voltage‐Gated Potassium Channels [PDF]

open access: yesAngewandte Chemie International Edition, 2009
Photochromic ligands (PCLs) can be optically switchedbetween isomers that show different biological activities. Assuch, they offer an opportunity to convert ligand-actuatedpathways into light-actuated pathways, thus making it possi-ble to control a wide range of biological processes with light.PCLs have been explored for various classes of ...
Matthew R, Banghart   +5 more
openaire   +2 more sources

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains [PDF]

open access: yes, 2015
Voltage-gated channels open paths for ion permeation upon changes in membrane potential, but how voltage changes are coupled to gating is not entirely understood.
Barros de la Roza, Francisco   +8 more
core   +1 more source

Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus

open access: yesFrontiers in Cellular Neuroscience, 2019
Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 ...
Jakob J. Gutzmann   +2 more
doaj   +1 more source

Outward Rectification of Voltage-Gated K+ Channels Evolved at Least Twice in Life History. [PDF]

open access: yesPLoS ONE, 2015
Voltage-gated potassium (K+) channels are present in all living systems. Despite high structural similarities in the transmembrane domains (TMD), this K+ channel type segregates into at least two main functional categories-hyperpolarization-activated ...
Janin Riedelsberger   +2 more
doaj   +1 more source

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