Results 201 to 210 of about 57,572 (247)
Advanced Science, EarlyView.This review explores emerging 2D materials beyond graphene, including graphdiyne, phosphorene, borophene, siloxene, MBene, antimonene, and germanene for Li/Na–S batteries. It analyzes their roles as sulfur hosts, metallic anode protectors, separators, and electrolyte fillers, emphasizing polysulfide suppression, dendrite inhibition, and interfacial ...
Naveen Kumar T. R +7 more
wiley +1 more source
Advanced Science, EarlyView.The sunscreen‐inspired nano‐pesticide, MCB@URFSL, provides UV‐shielding, enhanced rainfastness, and laccase‐responsive delivery for improved fungicidal efficacy and high ecological safety. ABSTRACT Fungicides are a crucial tool for protecting crops and ensuring consistent food supply.
Jin Yan +10 more
wiley +1 more source
<i>N</i>-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels. [PDF]
Mol PharmacolDenomme N +12 more
europepmc +1 more source
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Current Opinion in Pharmacology, 2015
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
openaire +3 more sources
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
openaire +3 more sources
Current Opinion in Pharmacology, 2001
Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
openaire +2 more sources
Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
openaire +2 more sources
Voltage-Gated Sodium Channels and Hyperalgesia
Annual Review of Pharmacology and Toxicology, 2004Physiological and pharmacological evidence both have demonstrated a critical role for voltage-gated sodium channels (VGSCs) in many types of chronic pain syndromes because these channels play a fundamental role in the excitability of neurons in the central and peripheral nervous systems. Alterations in function of these channels appear to be intimately
Josephine, Lai +3 more
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A Prokaryotic Voltage-Gated Sodium Channel
Science, 2001The pore-forming subunits of canonical voltage-gated sodium and calcium channels are encoded by four repeated domains of six-transmembrane (6TM) segments. We expressed and characterized a bacterial ion channel (NaChBac) from Bacillus halodurans that is encoded by one 6TM segment. The sequence,
D, Ren +5 more
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Ubiquitylation of Voltage-Gated Sodium Channels
2014Ion channel proteins are regulated by different types of posttranslational modifications. The focus of this review is the regulation of voltage-gated sodium channels (Navs) upon their ubiquitylation. The amiloride-sensitive epithelial sodium channel (ENaC) was the first ion channel shown to be regulated upon ubiquitylation.
Laedermann, Cédric J +2 more
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Voltage-Gated Sodium Channels and Pain
Current Drug Target -CNS & Neurological Disorders, 2004Voltage-gated sodium channels are highly specialized molecular transducers that play a significant role in the creation and transmission of electrical activity throughout the neuraxis. These ion channels are fundamentally involved in sensory neuron physiology and pathophysiology; a complete but localized suspension of their normal function can prevent ...
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Structural Pharmacology of Voltage-Gated Sodium Channels
Journal of Molecular Biology, 2021Voltage-gated sodium (NaV) channels initiate and propagate action potentials in excitable tissues to mediate key physiological processes including heart contraction and nervous system function. Accordingly, NaV channels are major targets for drugs, toxins and disease-causing mutations.
Sigrid Noreng, Tianbo Li, Jian Payandeh
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