Results 211 to 220 of about 57,572 (247)

Voltage-Gated Sodium Channels in Neurological Disorders

CNS & Neurological Disorders - Drug Targets, 2008
Voltage-gated sodium channels play an essential biophysical role in many excitable cells such as neurons. They transmit electrical signals through action potential (AP) generation and propagation in the peripheral (PNS) and central nervous systems (CNS). Each sodium channel is formed by one alpha-subunit and one or more beta-subunits.
Mohamed, Chahine, Aurélien, Chatelier, Olga, Babich, Johannes J, Krupp   +3 more
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Voltage-gated sodium channels as therapeutic targets

Drug Discovery Today, 2000
Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in neurons and other cells. VGSC modulators have their origins in empirical pharmacology and are being used as local anaesthetics, antiarrhythmics, analgesics and antiepileptics, and for other disorders.
, Clare, , Tate, , Nobbs, , Romanos
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Conotoxin modulation of voltage-gated sodium channels

The International Journal of Biochemistry & Cell Biology, 2008
The rising phase of the action potential in excitable cells is mediated by voltage-gated sodium channels (VGSCs), of which there are nine mammalian subtypes with distinct tissue distribution and biophysical properties. The involvement of certain VGSC subtypes in disease states such as pain and epilepsy highlights the need for agents that modulate VGSCs
Ekberg, Jenny, Craik, David J, Adams, David J   +2 more
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Voltage-Gated Sodium Channel Blockers as Immunomodulators

Recent Patents on CNS Drug Discovery, 2006
Several Voltage-Gated Sodium Channels (VGSC) are widely expressed on lymphocytes and macrophages but their role in immune function is still debated. Nevertheless, Na(+) influx through VGSC is required for lymphocytes activation and proliferation, since these responses are blocked by Na(+)-free medium or by VGSC blockers.
ROSELLI F, LIVREA, Paolo, JIRILLO, Emilio   +2 more
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Voltage‐gated sodium channels and pain pathways

Journal of Neurobiology, 2004
AbstractAcute, inflammatory, and neuropathic pain can all be attenuated or abolished by local treatment with sodium channel blockers such as lidocaine. The peripheral input that drives pain perception thus depends on the presence of functional voltage‐gated sodium channels.
John N, Wood, James P, Boorman, Kenji, Okuse, Mark D, Baker   +3 more
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Voltage Gated Sodium Channels

2014
Overview: biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels.- Slow inactivation of Na+ channels.- Regulation/modulation of sensory neuron sodium channels.- Ubiquitylation of voltage-gated sodium channels.- Probing gating mechanisms of sodium channel using pore blockers.- Animal toxins influence ...
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Risperidone inhibits voltage-gated sodium channels

European Journal of Pharmacology, 2014
In contrast to several other antipsychotic drugs, the effects of the atypical antipsychotic risperidone on voltage-gated sodium channels have not been characterized yet, despite its wide clinical use. Here we performed whole-cell voltage-clamp recordings to analyze the effects of risperidone on voltage-dependent sodium currents of N1E-115 mouse ...
Jan M, Brauner, Sabine, Hessler, Teja W, Groemer, Christian, Alzheimer, Tobias, Huth   +4 more
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Diversity of Mammalian Voltage‐Gated Sodium Channels

Annals of the New York Academy of Sciences, 1999
ABSTRACT: A variety of different isoforms of mammalian voltage‐gated sodium channels have been identified. These channels can be classified into three different types. Eight type 1 isoforms have been identified in the CNS, PNS, skeletal muscle, and heart.
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Voltage gated sodium channels

RCSB Protein Data Bank, 2020
Tomas Koltai, Stephan J. Reshkin, Salvador Harguindey   +2 more
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Toxins That Affect Voltage-Gated Sodium Channels

2017
Voltage-gated sodium channels (VGSCs) are critical in generation and conduction of electrical signals in multiple excitable tissues. Natural toxins, produced by animal, plant, and microorganisms, target VGSCs through diverse strategies developed over millions of years of evolutions.
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