Results 11 to 20 of about 108,977 (287)

Cannabidiol interactions with voltage-gated sodium channels [PDF]

eLife, 2020
Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two
Lily Goodyer Sait, Altin Sula, Mohammad-Reza Ghovanloo, David Hollingworth, Peter C Ruben, BA Wallace   +5 more
doaj   +4 more sources

Excitability constraints on voltage-gated sodium channels. [PDF]

PLoS Computational Biology, 2007
We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical
Elaine Angelino, Michael P Brenner
doaj   +4 more sources

Inhibition of Voltage-Gated Sodium Channels by Animal Toxins [PDF]

Structural Dynamics
Voltage-gated sodium channels (NaVs) play important roles in propagating action potentials and their structure and function can be modulated by a variety of factors, including animal toxins.
Shane Gonen
doaj   +2 more sources

Spider neurotoxins targeting voltage-gated sodium channels [PDF]

Toxin Reviews, 2005
The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides, and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate sodium channel gating and/or kinetics.
Little, MJ, Nicholson, GM
core   +2 more sources

Unmasking of Brugada syndrome by lamotrigine in a patient with pre-existing epilepsy: A case report with review of the literature

Frontiers in Cardiovascular Medicine, 2022
Brugada syndrome is an inherited cardiac channelopathy arising from mutations in voltage-gated cardiac sodium channels. Idiopathic epilepsy portrays a coalescent underlying pathophysiological mechanism pertaining to the premature excitation of neuronal ...
Hafiz Omer, Hafiz Omer, Mohamed H. Omer, Abdulmohsen R. Alyousef, Ali M. Alzammam, Omar Ahmad, Haitham A. Alanazi, Haitham A. Alanazi, Haitham A. Alanazi   +8 more
doaj   +1 more source

Neurological perspectives on voltage-gated sodium channels [PDF]

Brain, 2016
The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders.
Abrahamsen, Akopian, Akopian, Alabi, Alzheimer, Amaya, Aurlien, Baker, Baker, Bennett, Beyreuther, Beyreuther, Beyreuther, Binshtok, Binshtok, Biton, Black, Black, Black, Black, Bohle, Bosmans, Brackenbury, Brittain, Bromley, Burge, Calabresi, Campbell, Cannon, Cardenas, Carrithers, Carter, Cattaneo, Catterall, Catterall, Cestele, Chambers, Chen, Cheung, Chioni, Choi, Chong, Clare, Conway, Corry, Cossette, Cox, Cox, Cummins, Cummins, Devor, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dib-Hajj, Dichgans, Diss, Doty, Drizin, Durham, Ebell, Escayg, Estacion, F. Rugiero, Fang, Fertleman, Fink, Fischer, Fischer, Fraser, Fraser, French, Ganjehei, Garrido, Gasser, Giardina, Goldberg, Graff-Radford, Grieco, Haimovich, Hains, Hains, Hakim, Harmer, Hasegawa, Hedstrom, Herfst, Hernandez-Plata, Heron, Hewitt, Hille, Hiyama, Holland, Hollmann, Hoyt, Hsueh, Huth, Iqbal, Isom, Isom, J. E. Linley, J. N. Wood, Jang, Jarecki, Jiang, Jiang, Joshi, Jurkat-Rott, Kalra, Kalume, Kapoor, Kapoor, Kapplinger, Kearney, Kerr, Khasar, Khoromi, Kort, Kudrow, Kuhnert, Kyndt, Lai, Lamas, Lampl, Leo, Leterrier, Liao, Lim, Lin, Lindia, Liu, London, Lopez-Santiago, Lopez-Santiago, M. D. Baker, M. S. Minett, Mackenzie, Maitre, Mantegazza, Mao, Marini, McGowan, Meisler, Meisler, Minett, Misra, Mohammadi, Muth-Selbach, N. Eijkelkamp, Nalamachu, Nassar, Nassar, Nattel, Naylor, Nuyens, O'Malley, O'Roak, O'Roak, Okuse, Onkalp, Ou, Oyama, Padilla, Patino, Patino, Patino, Patlak, Payandeh, Payandeh, Pertin, Perucca, Pittenger, Planells-Cases, Poolos, Poon, Priest, Pt  cek, R. Cregg, R. Werdehausen, Ragsdale, Ragsdale, Ragsdale, Rajakulendran, Raman, Rauck, Renganathan, Rivera-Acevedo, Roberson, Robinson, Rogart, Rogawski, Ruetsch, Rugiero, Rusconi, Saenen, Sanders, Schwarz, Schwindt, Shank, Shao, Shao, Sijben, Smith, Sokolov, Song, Spampanato, Starmer, Stefani, Stevens, Stummann, Stys, St  hmer, St  hr, Sugawara, Tan, Taverna, Toledo-Aral, Uebachs, Vahedi, Vassilev, Vassilev, Veeramah, Veneroni, Volkers, von Gunten, Wang, Wang, Wang, Watanabe, Watanabe, Waxman, Waxman, Weiser, Weiss, Weiss, Weiss, West, Westenbroek, Whitaker, Wimmer, Wood, Yang, Yu, Yu, Zimmer, Zimmermann   +247 more
core   +5 more sources

Voltage-gated sodium channels gene expression in Burning Mouth Syndrome: a case-control study

Brazilian Oral Research, 2023
Burning mouth syndrome (BMS) is a condition characterized by painful symptoms of the oral mucosa, despite the absence of any clinical signs. Its etiology is unknown, and there is still no effective treatment to date.
Carina DOMANESCHI, Vanessa Juliana Gomes CARVALHO, Bruno Munhoz MAROTTA, Norberto Nobuo SUGAYA, Fábio Daumas NUNES, Camila de Barros GALLO   +5 more
doaj   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

Toxins, 2016
The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P.
Fernando Lazcano-Pérez, Héctor Castro, Isabel Arenas, David E. García, Ricardo González-Muñoz, Roberto Arreguín-Espinosa   +5 more
doaj   +1 more source

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels

Frontiers in Physiology, 2015
Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH, Hugues eAbriel   +1 more
doaj   +1 more source