Results 21 to 30 of about 107,111 (187)

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels

Frontiers in Physiology, 2015
Voltage-gated sodium channels (Nav) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of ...
Mohamed-Yassine eAMAROUCH, Hugues eAbriel   +1 more
doaj   +1 more source

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. [PDF]

, 2016
The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule ...
Goldstein, Steve An, Marks, Jeremy D, Plant, Leigh D   +2 more
core   +2 more sources

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review

Heliyon, 2023
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj   +1 more source

An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids [PDF]

, 2015
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin.
Amey, Joanna S., Burton, Mark J., Davies, T.G. Emyr, Duce, Ian R., Field, Linda M., Mellor, Ian R., O'Reilly, Andrias O., Puinean, Alin M., Wallace, B.A., Williamson, Martin S.   +9 more
core   +1 more source

Nomenclature of Voltage-Gated Sodium Channels [PDF]

Neuron, 2000
Voltage-gated Ca2+ channels mediate calcium influx in response to membrane depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. They are members of a gene superfamily of transmembrane ion channel proteins that includes voltage-gated K+ and Na+ channels.
Goldin, Alan L., Barchi, Robert L., Caldwell, John H., Hofmann, Franz, Howe, James R., Hunter, John C., Kallen, Roland G., Mandel, Gail, Meisler, Miriam H., Netter, Yoheved Berwald, Noda, Masahara, Tamkun, Michael M., Waxman, Steven G., Wood, John N., Catterall, William A.   +14 more
openaire   +2 more sources

Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines. [PDF]

, 2007
Ionic channel activity is involved in fundamental cellular behaviour and participates in cancerous features such as proliferation, migration and invasion which in turn contribute to the metastatic process.
Barascu, Aurélia, Besson, Pierre, Bougnoux, Philippe, Gruel, Yves, Iochmann, Sophie, Le Guennec, Jean-Yves, Lei, Ming, Raynal, Pierre-Ivan, Roger, Sébastien, Rollin, Jérôme   +9 more
core   +3 more sources

Determining the structure of the bacterial voltage-gated sodium channel NaChBac embedded in liposomes by cryo electron tomography and subtomogram averaging

Scientific Reports, 2023
Voltage-gated sodium channels shape action potentials that propagate signals along cells. When the membrane potential reaches a certain threshold, the channels open and allow sodium ions to flow through the membrane depolarizing it, followed by the ...
Shih-Ying Scott Chang, Patricia M. Dijkman, Simon A. Wiessing, Misha Kudryashev   +3 more
doaj   +1 more source

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel [PDF]

, 2013
The crystal structure of the open conformation of a bacterial voltage-gated sodium channel pore from Magnetococcus sp. (NaVMs) has provided the basis for a molecular dynamics study defining the channel’s full ion translocation pathway and conductance ...
Bagneris, Claire, Clapham, D.E., DeCaen, P.G., Delling, M., McCusker, Emily C., Ulmschneider, J.P., Ulmschneider, Martin B., Wallace, Bonnie A.   +7 more
core   +1 more source

Voltage-Gated Sodium Channels in Neocortical Pyramidal Neurons Display Cole-Moore Activation Kinetics

Frontiers in Cellular Neuroscience, 2018
Exploring the properties of action potentials is a crucial step toward a better understanding of the computational properties of single neurons and neural networks. The voltage-gated sodium channel is a key player in action potential generation.
Mara Almog, Tal Barkai, Angelika Lampert, Alon Korngreen, Alon Korngreen   +4 more
doaj   +1 more source

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Molecular Brain, 2020
Chronic pain can be the result of an underlying disease or condition, medical treatment, inflammation, or injury. The number of persons experiencing this type of pain is substantial, affecting upwards of 50 million adults in the United States ...
Yuan Zhou, Song Cai, Kimberly Gomez, E. M. Kithsiri Wijeratne, Yingshi Ji, Shreya S. Bellampalli, Shizhen Luo, Aubin Moutal, A. A. Leslie Gunatilaka, Rajesh Khanna   +9 more
doaj   +1 more source