Results 101 to 110 of about 6,531,738 (232)

Dual-Copy VP2 expressed with CTA1-DD in transgenic Eimeria acervulina confers partial protection against infectious bursal disease virus

open access: yesPoultry Science
Infectious bursal disease (IBD), caused by the infectious bursal disease virus (IBDV), remains a major threat to global poultry production. The viral capsid protein VP2 is the primary protective antigen; however, conventional vaccines frequently provide ...
Yingying Sun   +8 more
doaj   +1 more source

Canine Parvovirus VP2 Protein Expressed in Silkworm Pupae Self-Assembles into Virus-Like Particles with High Immunogenicity

open access: yesPLoS ONE, 2014
The VP2 structural protein of parvovirus can produce virus-like particles (VLPs) by a self-assembly process in vitro, making VLPs attractive vaccine candidates.
Hao Feng   +13 more
semanticscholar   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

open access: yesAdvanced Science, Volume 13, Issue 21, 13 April 2026.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin   +13 more
wiley   +1 more source

Immunogenicity of recombinant VP2 proteins of all nine serotypes of African horse sickness virus [PDF]

open access: yesVaccine, 2014
African horse sickness (AHS) is an equine disease with a mortality of up to 90% for susceptible horses. The causative agent AHS virus (AHSV) is transmitted by species of Culicoides. AHSV serogroup within the genus Orbivirus of the Reoviridae family consists of nine serotypes that show no or very limited cross-neutralization.
Kanai, Y.   +5 more
openaire   +2 more sources

Effect of a silencing suppressor gene towards the expression of VP2 protein of highly virulent infectious bursal disease virus in tobacco [PDF]

open access: yesJournal of BioScience and Biotechnology, 2013
Gene silencing has been recognized as an important factor, which influence the expression of heterologous protein delivered via plant-viral based system.
Siti-Hasmah Mohtar   +3 more
doaj  

Full-length VP2 gene analysis of canine parvovirus reveals emergence of newer variants in India [PDF]

open access: yes, 2016
The canine parvovirus (CPV) infection is a highly contagious and serious enteric disease of dogs with high fatality rate. The present study was taken up to characterize the full-length viral polypeptide 2 (VP2) gene of CPV of Indian origin along with the
Antony, Prabhakar Xavier   +7 more
core   +1 more source

Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1058-1068, April 2026.
Background and Aim The rise of drug‐resistant tuberculosis (TB) poses a need for new drugs and combinations. TBAJ‐587, a new diarylquinoline (DARQ), has shown promising efficacy in preclinical studies. This work aimed to describe the pharmacokinetics (PK) of TBAJ‐587 and its metabolites M2 and M3 after single ascending dosing in healthy volunteers and ...
Albin A. M. Leding   +6 more
wiley   +1 more source

Construction of Recombinant Baculoviruses Expressing Infectious Bursal Disease Virus Main Protective Antigen and Their Immune Effects on Chickens. [PDF]

open access: yesPLoS ONE, 2015
In order to overcome the limitations of conventional vaccines for infectious bursal disease virus (IBDV), we constructed recombinant dual expression system baculoviruses with VP2 and VP2/4/3, the main protective antigens of IBDV.
Jingping Ge   +4 more
doaj   +1 more source

Efficacy and Safety of Intensity‐Modulated Radiotherapy Combined With Regorafenib With or Without Immune Checkpoint Inhibitors as Second‐Line Treatment for Advanced Hepatocellular Carcinoma: A Real‐World Cohort Study From a Single Center

open access: yesCancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Purpose This study aimed to assess the efficacy and safety of intensity‐modulated radiotherapy (IMRT) combined with regorafenib with or without immune checkpoint inhibitors (ICIs) as a second‐ or later‐line treatment for advanced hepatocellular carcinoma (HCC).
Lingxia Xin   +22 more
wiley   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

open access: yes, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar   +54 more
core   +1 more source

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