Results 81 to 90 of about 6,531,738 (232)
Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures [PDF]
, 2017 Vesivirus 2117 is an adventitious agent that in 2009, was identified as a contaminant of CHO cells propagated in bioreactors at a pharmaceutical manufacturing plant belonging to Genzyme.
Bhella, David +8 more
core +1 more source
A Mechanistic Model of rAAV Production in Synthetic Cell Lines
Biotechnology and Bioengineering, EarlyView.ABSTRACT The recombinant adeno‐associated virus (rAAV) is a widely used vector for gene therapy. Its manufacturing faces significant challenges in producing the large quantities of vectors needed for clinical applications and reducing empty particles.
Prahalad Srinivasan +5 more
wiley +1 more source
PLoS ONE, 2021 There are a wide variety of porcine parvoviruses (PPVs) referred to as PPV1 to PPV7. The latter was discovered in 2016 and later reported in some countries in America, Asia, and Europe.
Diana S Vargas-Bermudez +4 more
doaj +1 more source
Mathematical model of a serine integrase-controlled toggle switch with a single input [PDF]
, 2018 Dual-state genetic switches that can change their state in response to input signals can be used in synthetic biology to encode memory and control gene expression.
Colloms, Sean D. +3 more
core +1 more source
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND Adeno‐Associated Virus vectors are widely used in gene therapy due to their safety and efficacy. Despite the interest in their therapeutical application, AAV purification remains a significant challenge. Density gradient ultracentrifugation using cesium chloride, sucrose, or iodixanol gradients are common methods for AAV ...
Sabrina Leigheb +6 more
wiley +1 more source
Feline calicivirus can tolerate gross changes of its minor capsid protein expression levels induced by changing translation reinitiation frequency or use of a separate VP2-coding mRNA. [PDF]
PLoS ONE, 2014 Caliciviruses use reinitiation of translation governed by a 'termination upstream ribosomal binding site' (TURBS) for expression of their minor capsid protein VP2.
Maria Haβ +2 more
doaj +1 more source
Veterinary Integrative Sciences, 2022 Porcine parvovirus 1 (PPV1) is the causative agent of swine reproductive disease, particularly in naive gilts and sows. This study aimed to investigate the prevalence and genetic diversity of the partial nucleotide sequence of the VP2 gene and ...
Prayuth Saekhow +2 more
doaj +1 more source
Identification of T-cell receptor a-chain genes in the chicken [PDF]
, 1994 T-cell receptor (TCR) -chain (TCR) and ß-chain (TCRß) genes are well characterized in mammals, while only TCRß genes have been identified in other vertebrates. To identify avian TCR genes, we used monoclonal anti-CD3 antibodies to isolate chicken TCR for
Aebersold, Ruedi +7 more
core
Ion Activation Methods for Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley +1 more source
Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal [PDF]
, 2006 In Xenopus, the establishment of the anteroposterior axis involves two key signalling pathways, canonical Wnt and Nodal-related TGFbeta. There are also a number of transcription factors that feedback upon these pathways.
Brickman, Joshua M +5 more
core +1 more source