Results 31 to 40 of about 5,739 (164)

Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent Mechanisms. [PDF]

PLoS ONE, 2016
Trypanosoma brucei causes debilitating human African trypanosomiasis and evades the host's immune response by regularly switching its major surface antigen, VSG, which is expressed exclusively from subtelomeric loci.
Sanaa E Jehi, Vishal Nanavaty, Bibo Li
doaj   +1 more source

An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome

Nature Communications, 2023
UPF1-like helicases play roles in telomeric heterochromatin formation and X-chromosome inactivation, and also in monogenic variant surface glycoprotein (VSG) expression via VSG exclusion-factor-2 (VEX2), a UPF1-related protein in the African trypanosome.
Joana R. C. Faria, Michele Tinti, Catarina A. Marques, Martin Zoltner, Harunori Yoshikawa, Mark C. Field, David Horn   +6 more
doaj   +1 more source

Power stability control of wind-PV-battery AC microgrid based on two-parameters fuzzy VSG

Frontiers in Energy Research, 2023
Virtual synchronous generator (VSG) control addresses the issue of decreasing microgrid standby inertia caused by the rise in wind turbines and photovoltaic (PV) penetration. However, various types of perturbations occur frequently making the traditional
Wenwei Zhou, Binjie Wang, Jipeng Gu, Youbing Zhang, Shuyi Wang, Yixuan Wu   +5 more
doaj   +1 more source

Cohesin regulates VSG monoallelic expression in trypanosomes [PDF]

Journal of Cell Biology, 2009
Antigenic variation allows Trypanosoma brucei to evade the host immune response by switching the expression of 1 out of ∼15 telomeric variant surface glycoprotein (VSG) expression sites (ESs). VSG ES transcription is mediated by RNA polymerase I in a discrete nuclear site named the ES body (ESB).
Landeira, David, Bart, Jean-Mathieu, Van Tyne, D., Navarro, M.   +3 more
openaire   +3 more sources

Description of the skull, braincase, and dentition of Moschognathus whaitsi (Dinocephalia, Tapinocephalia), and its palaeobiological and behavioral implications

The Anatomical Record, EarlyView.
Abstract A subadult Moschognathus whaitsi from the Eastern Cape Province, South Africa, was scanned using synchrotron radiation X‐ray computed tomography (SRXCT). Its subadult state allowed the cranial bones and teeth to be identified and individually reconstructed in 3D.
Tristen Lafferty, Luke A. Norton, Aliénor Duhamel, Julien Benoit   +3 more
wiley   +1 more source

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

eLife, 2016
Survival of Trypanosoma brucei depends upon switches in its protective Variant Surface Glycoprotein (VSG) coat by antigenic variation. VSG switching occurs by frequent homologous recombination, which is thought to require locus-specific initiation. Here,
Rebecca Devlin, Catarina A Marques, Daniel Paape, Marko Prorocic, Andrea C Zurita-Leal, Samantha J Campbell, Craig Lapsley, Nicholas Dickens, Richard McCulloch   +8 more
doaj   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, EarlyView.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

Average Model and Controller Design for Virtual Synchronous Generator

IEEE Access
This paper proposes a novel systematic design procedure for virtual synchronous generators (VSGs) and develops an average VSG model. The VSG comprises distributed generators, an energy storage system consisting of a battery and a DC-DC converter (DDC ...
Kenta Koiwa, Tomo Hirabayashi, Tadanao Zanma, Kang-Zhi Liu   +3 more
doaj   +1 more source

Saliva Sampling and Testing Strategies for Screening AD Biomarkers Using a Portable Antibody Functionalized Bioanalyzer Platform [PDF]

Alzheimers Dement
Abstract Background Saliva collection has been explored for non‐invasive AD biomarker testing in several studies (Kirmess et al.,2021, De Meyer et al.,2020), however, challenges persist in maintaining consistent sampling and reliable benchmarking for the low salivary Aß42 concentration in healthy controls (0.6‐66.1pg/ml; Agnello et al.,2024, Sabbagh et
Johri S, Layton‐Matthews D, Frank A, Arora A, Doukhanine E, Iwasiow R, Prakash R.   +6 more
europepmc   +2 more sources

Preoperative Weight Trends in Adolescents Undergoing Metabolic and Bariatric Surgery

Obesity, EarlyView.
ABSTRACT Objective Preoperative weight changes, predictors of weight changes, and subsequent implications on postoperative BMI reduction in adolescents preparing for bariatric surgery (MBS) have not been well described. Methods Teen–Longitudinal Assessment of Bariatric Surgery (Teen‐LABS) consortium (prospective, observational MBS study at five centers
Sarah B. Ogle, Emily H. Meneses, Alexander M. Kaizer, Jaime M. Moore, James E. Mitchell, Marc P. Michalsky, Thomas Inge   +6 more
wiley   +1 more source