Results 71 to 80 of about 104,334 (371)
Blood, 2015 In this issue of Blood, back-to-back (dos-à-dos) papers by Chiu et al and Yee et al present complementary findings of structural investigations into the interaction between factor VIII (FVIII) and von Willebrand factor (VWF). The binding of FVIII to VWF contributes in a major way to the regulation of hemostasis.
openaire +2 more sources
Identification and functional analysis of a novel von Willebrand factor mutation in a family with type 2A von Willebrand disease. [PDF]
PLoS ONE, 2012 von Willebrand factor (VWF) is essential for normal hemostasis. VWF gene mutations cause the hemorrhagic von Willebrand disease (VWD). In this study, a 9-year-old boy was diagnosed as type 2A VWD, based on a history of abnormal bleeding, low plasma VWF ...
Jing Dong +7 more
doaj +1 more source
Behaviour of the von Willebrand Factor in Blood Flow [PDF]
, 2014 This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014) +3 more
core
Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]
, 2014 Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright +17 more
core +1 more source
The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity
Journal of Clinical Investigation, 2018 Quantitative abnormalities of the von Willebrand factor–factor VIII (VWF-FVIII) complex associate with inherited bleeding or thrombotic disorders. Receptor-mediated interactions between plasma VWF-FVIII and phagocytic or immune cells can influence their ...
L. Swystun +14 more
semanticscholar +1 more source
Shear-Induced Unfolding and Enzymatic Cleavage of Full-Length VWF Multimers. [PDF]
Biophysical Journal, 2015 Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF within the mechanosensitive A2 domain, which is believed to open under shear flow.
Svenja Lippok +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Clinical and Applied Thrombosis/Hemostasis, 2020 von Willebrand factor (VWF) acts as a bridge between platelets and the subendothelial matrix following vessel damage and plays a vital role in coronary artery disease (CAD).
Bin Yan MS +8 more
doaj +1 more source
Testing the Yang-Mills vacuum wave functional Ansatz in 3+1 dimensions
, 2013 We proposed a simple Ansatz for the vacuum wave functional (VWF) of SU(2) gauge theory in temporal gauge. In 2+1 dimensions, the Ansatz was shown to be a fairly good approximation to the true VWF of the theory.
Greensite, J., Olejnik, S.
core +1 more source
Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease. [PDF]
, 2016 OBJECTIVE: To examine whether lung endothelial cells (ECs) from patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) express mesenchymal cell-specific proteins and gene transcripts, indicative of the occurrence of endothelial-
Arciniegas +41 more
core +2 more sources