Results 21 to 30 of about 252,763 (309)

Selective Inhibition of NaV1.8 with VX-548 for Acute Pain.

New England Journal of Medicine, 2023
BACKGROUND The NaV1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548, an oral, highly selective inhibitor of NaV1.8, on control of acute pain is being ...
Jim Jones, D. Correll, S. Lechner, Ina Jazic, Xiaopeng Miao, David Shaw, Christopher Simard, Jeremiah D. Osteen, Brian Hare, Alina Beaton, Todd Bertoch, A. Buvanendran, Ashraf S Habib, L. Pizzi, R. Pollak, S. Weiner, C. Bozic, PaulA . Negulescu, P. White   +18 more
semanticscholar   +1 more source

Photoaffinity Ligand of Cystic Fibrosis Corrector VX-445 Identifies SCCPDH as an Off-Target. [PDF]

ACS Chem Biol
Kim M, Kim K, Lee J, Barny LA, Scaggs TD, Romaine IM, Jeon K, Codreanu SG, Sherrod SD, McLean JA, Naren AP, Sulikowski GA, Plate L.   +12 more
europepmc   +2 more sources

Chemical Weapons in the Iran-Iraq War (1980-1988) Iraq Preparing for Chemical War

Вестник войск РХБ защиты, 2023
The Iraqis became the first nation to use chemical weapons on the modern battlefield during the IranIraq War (1980-1988). There are no general reviews and research available on this issue in Russian.
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Theratyping of the Rare CFTR Genotype A559T in Rectal Organoids and Nasal Cells Reveals a Relevant Response to Elexacaftor (VX-445) and Tezacaftor (VX-661) Combination

International Journal of Molecular Sciences, 2023
Despite the promising results of new CFTR targeting drugs designed for the recovery of F508del- and class III variants activity, none of them have been approved for individuals with selected rare mutations, because uncharacterized CFTR variants lack ...
K. Kleinfelder, V. Villella, Anca Manuela Hristodor, C. Laudanna, G. Castaldo, F. Amato, P. Melotti, C. Sorio   +7 more
semanticscholar   +1 more source

Emphasis on Temporal Association between Oral Verruciform Xanthoma and Candidal Infection: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2023
Oral Verruciform Xanthoma (VX) is a verrucopapillary lesion seen as a cauliflower-like/papillary growth in the oral cavity. The aetiopathophysiology of VX is explained by several pathogenic processes.
Reshma Poothakulath Krishnan, Deepak Pandiar   +1 more
doaj   +1 more source

Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours

British Journal of Cancer, 2021
Berzosertib (formerly M6620, VX-970) is a highly potent and selective, first-in-class inhibitor of ataxia telangiectasia and Rad3-related protein kinase (ATR). We assessed multiple ascending doses of berzosertib + gemcitabine ± cisplatin in patients with
M. Middleton, E. Dean, T. Evans, G. Shapiro, John Pollard, B. Hendriks, M. Falk, I. Díaz-Padilla, R. Plummer   +8 more
semanticscholar   +1 more source

The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice

bioRxiv, 2022
Background HIV-1 infection results in the activation of inflammasome involving NLRP3, IFI16, caspase-1 and release of IL-1 β and IL-18. Early inflammasome activation may facilitate viral spread and establishment of the viral reservoir.
Mathieu Amand, Philipp Adams, Rafaëla Schober, Gilles Iserentant, J. Servais, M. Moutschen, C. Seguin-Devaux   +6 more
semanticscholar   +1 more source

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults

Pain medicine (Malden, Mass.), 2021
Objective To evaluate the analgesic potential, safety, tolerability, and pharmacokinetics of VX-150, a pro-drug of a highly selective NaV1.8 inhibitor, in healthy subjects.
H. Hijma, P. Siebenga, M. D. de Kam, G. Groeneveld   +3 more
semanticscholar   +1 more source

Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells. [PDF]

PLoS ONE, 2015
P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells.
Bruce A Stanton, Bonita Coutermarsh, Roxanna Barnaby, Deborah Hogan   +3 more
doaj   +1 more source

On reciprocal degree distance of graphs

Heliyon, 2023
Given a connected graph H, its reciprocal degree distance is defined asRDD(H)=∑x≠ydH(vx)+dH(vy)dH(vx,vy), where dH(vx) denotes the degree of the vertex vx in the graph H and dH(vx,vy) is the shortest distance between vx and vy in H.
Mingqiang An, Yinan Zhang, Kinkar Chandra Das, Yilun Shang   +3 more
doaj   +1 more source