Results 21 to 30 of about 246,536 (223)

Post-VX exposure treatment of rats with engineered phosphotriesterases

Archives of Toxicology, 2021
The biologically stable and highly toxic organophosphorus nerve agent (OP) VX poses a major health threat. Standard medical therapy, consisting of reactivators and competitive muscarinic receptor antagonists, is insufficient.
Lisa Stigler, Anja Köhler, M. Koller, Laura Job, Benjamin Escher, H. Potschka, H. Thiermann, A. Skerra, F. Worek, T. Wille   +9 more
semanticscholar   +1 more source

A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Nav1.8 inhibitor, in healthy adults

Clinical and Translational Science, 2021
Selective inhibition of certain voltage‐gated sodium channels (Navs), such as Nav1.8, is of primary interest for pharmacological pain research and widely studied as a pharmacological target due to its contribution to repetitive firing, neuronal ...
H. Hijma, Emilie van Brummelen, P. Siebenga, G. Groeneveld   +3 more
semanticscholar   +1 more source

VX Hydrolysis by Human Serum Paraoxonase 1: A Comparison of Experimental and Computational Results [PDF]

, 2011
Human Serum paraoxonase 1 (HuPON1) is an enzyme that has been shown to hydrolyze a variety of chemicals including the nerve agent VX. While wildtype HuPON1 does not exhibit sufficient activity against VX to be used as an in vivo countermeasure, it has ...
AR Fersht, B Mackness, CL Kuo, D Josse, D Rochu, D Weininger, DA Case, DI Draganov, DJ Tantillo, Douglas M. Cerasoli, DT Yeung, DT Yeung, GM Morris, J Gasteiger, J Newmark, John Parkinson, K Cannard, M Harel, Matthew W. Peterson, Mojdeh Mohtashemi, N Eswar, O Khersonsky, O Khersonsky, P Rydberg, Q Wang, Steven Z. Fairchild, SZ Fairchild, Tamara C. Otto, TC Otto, TC Otto, TT Sanan, V Hornak, Wenling E. Chang, WL Jorgensen, X Hu, Y Zhang, Y Zhang   +36 more
core   +3 more sources

Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX‐661 + VX‐770 treatment on disease severity

Journal of Physiology, 2021
Cystic fibrosis transmembrane conductance regulator (CFTR) has an essential role in maintaining pancreatic ductal function. Impaired CFTR function can trigger acute pancreatitis (AP) and exacerbate disease severity.
Gabriella Fűr, E. Bálint, E. Orján, Z. Balla, E. Kormányos, B. Czira, Attila Szűcs, Dénes Péter Kovács, P. Pallagi, J. Maléth, V. Venglovecz, P. Hegyi, L. Kiss, Z. Rakonczay   +13 more
semanticscholar   +1 more source

Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur mustard, soman and VX [PDF]

, 2019
Background/Aims: Following an incident involving toxic chemicals, deployment of countermeasures before the arrival of specialised services at the scene may provide a “therapeutic” window in which to mitigate skin absorption.
Chilcott, Robert, Matar, Hazem, Price, Shirley   +2 more
core   +2 more sources

Efficient agent degradation within skin is important for decontamination of percutaneously exposed VX

Cutaneous and Ocular Toxicology, 2021
Aim of the study Following percutaneous exposure to the nerve agent VX, the remaining intact agent within the skin after decontamination is of great concern.
L. Thors, E. Wigenstam, J. Qvarnström, A. Bucht   +3 more
semanticscholar   +1 more source

VX‐809 mitigates disease in a mouse model of autosomal dominant polycystic kidney disease bearing the R3277C human mutation

The FASEB Journal, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is associated with the formation of renal cysts. We have devised a therapeutic approach, based on reversing the cyst phenotype from secretion to absorption by using VX‐809, a modulator of the cystic ...
M. Yanda, L. Cebotaru
semanticscholar   +1 more source

Genetic parameters and genomic regions associated with piglet response to vaccination for porcine reproductive and respiratory syndrome (PRRS) virus and co-infection with PRRS virus and porcine circovirus type 2b (PCV2b) [PDF]

, 2016
Citation: Dunkelberger, J. R., Serao, N. V. L., Kerrigan, M. A., Lunney, J. K., Rowland, R. R. R., & Dekkers, J. C. M. (2016). Genetic parameters and genomic regions associated with piglet response to vaccination for porcine reproductive and respiratory ...
Dekkers, J. C. M., Dunkelberger, J. R., Kerrigan, M. A., Lunney, J. K., Rowland, Raymond R., Serao, N. V. L.   +5 more
core   +1 more source

Quantum Phases in Partially Filled Landau Levels [PDF]

, 2004
We compare the energies of different electron solids, such as bubble crystals with triangular and square symmetry and stripe phases, to those of correlated quantum liquids in partially filled intermediate Landau levels. Multiple transitions between these
Goerbig, M. O., Lederer, P., Smith, C. Morais   +2 more
core   +2 more sources

Optimal Source Tracking and Beaming of LISA [PDF]

, 2006
We revisit the directionally optimal data streams of LISA first introduced in Nayak etal. It was shown that by using appropriate choice of Time delay interferometric (TDI) combinations, a monochromatic fixed source in the barycentric frame can be ...
Pai, Archana
core   +3 more sources