Results 31 to 40 of about 246,536 (223)

Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial

open access: yesBritish Journal of Cancer, 2020
Background The cancer vaccine Vx-001, which targets the universal tumour antigen TElomerase Reverse Transcriptase (TERT), can mount specific Vx-001/TERT 572 CD8 + cytotoxic T cells; this immune response is associated with improved overall survival (OS ...
C. Gridelli   +25 more
semanticscholar   +1 more source

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

open access: yesScience Translational Medicine, 2019
In utero and early postnatal functional rescue of cystic fibrosis transmembrane conductance regulator improves survival in cystic fibrosis ferrets. Tackling cystic fibrosis in the womb Cystic fibrosis (CF) is a multiorgan disease caused by mutations in ...
Xingshen Sun   +23 more
semanticscholar   +1 more source

Mesoscopic Kinetic Basis of Macroscopic Chemical Thermodynamics: A Mathematical Theory

open access: yes, 2016
From a mathematical model that describes a complex chemical kinetic system of $N$ species and $M$ elementrary reactions in a rapidly stirred vessel of size $V$ as a Markov process, we show that a macroscopic chemical thermodynamics emerges as $V ...
Ge, Hao, Qian, Hong
core   +1 more source

VX‐659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

open access: yesNew England Journal of Medicine, 2018
BACKGROUND The next‐generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector VX‐659, in triple combination with tezacaftor and ivacaftor (VX‐659–tezacaftor–ivacaftor), was developed to restore the function of Phe508del CFTR protein
J. Davies   +20 more
semanticscholar   +1 more source

No confinement without Coulomb confinement

open access: yes, 2002
We compare the physical potential $V_D(R)$ of an external quark-antiquark pair in the representation $D$ of SU(N), to the color-Coulomb potential $V_{\rm coul}(R)$ which is the instantaneous part of the 44-component of the gluon propagator in Coulomb ...
D. Zwanziger   +9 more
core   +2 more sources

VLTI/AMBER spectro-interferometric imaging of VX Sgr's inhomogenous outer atmosphere [PDF]

open access: yes, 2009
Aims. We aim to explore the photosphere of the very cool late-type star VX Sgr and in particular the existence and characterization of molecular layers above the continuum forming photosphere. Methods.
Chiavassa, A.   +10 more
core   +2 more sources

Application of 3D scanning technology in Royal Malaysian Air Force Industrial Revolution 4.0‐based aircraft maintenance

open access: yesIET Networks, EarlyView., 2022
Abstract 3D scanning is rapidly becoming a key maintenance tool. Aerospace was a pioneer in adopting 3D scanning technology because aircraft manufacture and maintenance require precision. Monitoring deterioration, removing components for maintenance, and verifying covert operations are not practical or helpful without technology.
T. Nanthakumaran Thulasy   +4 more
wiley   +1 more source

A double T‐type H‐bridge reduced switch multilevel inverter for a wide range of DC voltage variations

open access: yesIET Power Electronics, EarlyView., 2023
This paper proposes a new Double T‐type H‐bridge (DTH) module configuration that can produce 9, 13, 17, 19, 21, and 25 levels using reduced components. Abstract Renewable energy sources are subject to input source uncertainties, which can negatively impact output voltage THD.
Omid Zolfagharian   +2 more
wiley   +1 more source

Spin alignments of vector mesons in deeply inelastic lepton-nucleon scattering

open access: yes, 2002
We extend the calculations of the spin alignments of vector mesons in $e^+e^-$ annihilation in a recent Rapid Communication to deeply inelastic lepton-nucleon scatterings.
A.F. Falk   +19 more
core   +1 more source

VX‐765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke‐induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway

open access: yesCNS Neuroscience & Therapeutics, 2020
To investigate the protective effect of VX‐765 on human umbilical mesenchymal stem cells (HUMSCs) in stroke and its mechanism.
Zhezhe Sun   +9 more
semanticscholar   +1 more source

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