Results 31 to 40 of about 252,763 (309)

A Randomized Controlled Trial of Local Delivery of a Rho Inhibitor (VX-210) in Patients with Acute Traumatic Cervical Spinal Cord Injury

Journal of Neurotrauma, 2021
Acute traumatic spinal cord injury (SCI) can result in severe, lifelong neurological deficits. After SCI, Rho activation contributes to collapse of axonal growth cones, failure of axonal regeneration, and neuronal loss.
M. Fehlings, Yang Chen, B. Aarabi, F. Ahmad, K. Anderson, T. Dumont, D. Fourney, J. Harrop, Kee D. Kim, B. Kwon, Hari K. Lingam, M. Rizzo, L. Shih, E. Tsai, A. Vaccaro, L. Mckerracher   +15 more
semanticscholar   +1 more source

VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats

Journal of Molecular Neuroscience, 2022
Focal cortical infarction leads to secondary degeneration of the ipsilateral hippocampus, which is associated with poststroke cognitive impairment.
D. Dong, Aihui Ren, Ying Yang, Jiayi Su, Libin Liu, Wen-Yan Zhuo, Yubin Liang   +6 more
semanticscholar   +1 more source

Treatment of Polarized Cystic Fibrosis Airway Cells With HGF Prevents VX-661-Rescued F508del-CFTR Destabilization Caused by Prolonged Co-exposure to VX-770

Frontiers in Molecular Biosciences, 2021
Cystic fibrosis (CF), the most common inherited disease in Caucasians, is caused by mutations in CFTR, the most frequent of which is F508del. F508del causes ER retention and degradation of the mutant CFTR protein, but also defective channel gating and ...
Ana M. Matos, Ana M. Matos, Peter Jordan, Peter Jordan, Paulo Matos, Paulo Matos   +5 more
doaj   +1 more source

Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors

Journal of Clinical Oncology, 2020
PURPOSE Preclinical studies demonstrated that ATR inhibition can exploit synthetic lethality (eg, in cancer cells with impaired compensatory DNA damage responses through ATM loss) as monotherapy and combined with DNA-damaging drugs such as carboplatin ...
T. Yap, Brent O’Carrigan, M. Penney, J. Lim, Jessica Brown, M. J. De Miguel Luken, N. Tunariu, R. Pérez-López, D. Rodrigues, R. Riisnaes, I. Figueiredo, S. Carreira, B. Hare, K. McDermott, S. Khalique, C. Williamson, R. Natrajan, S. Pettitt, C. Lord, U. Banerji, Jack Pollard, Juanita Lopez, J. D. de Bono   +22 more
semanticscholar   +1 more source

The modulatory action of C-Vx substance on the immune system in COVID-19

Emerging Microbes and Infections, 2022
The modulatory effect of C-Vx, a novel therapeutic agent, on the immune system of COVID-19 patients was investigated. The functions of T and NK cells of COVID-19 patients with different disease severity were evaluated by flow cytometry in response to C ...
Ilhan Tahrali, Nilgun Akdeniz, Vuslat Yilmaz, Umut C. Kucuksezer, Fatma B. Oktelik, Ozkan Ozdemir, Esin Cetin-Aktas, Yelda Ogutmen, Arzu Ergen, Neslihan Abaci, Erdem Tuzun, Oral Oncul, Gunnur Deniz   +12 more
doaj   +1 more source

VX-659–Tezacaftor–Ivacaftor in patients with cystic fibrosis and one or two Phe508del alleles

Canadian Journal of Respiratory Critical Care and Sleep Medicine, 2020
Cystic fibrosis is an autosomal-recessive, multisystem disease that affects ∼80,000 patients worldwide.1,2 It is caused by mutations in the CFTR gene, an epithelial chloride ion channel with varyin...
E. Merman, M. Stanbrook, A. Anand
semanticscholar   +1 more source

VX-765 reduces neuroinflammation after spinal cord injury in mice

Neural Regeneration Research, 2021
Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord.
J. Chen, Yu‐qing Chen, Yu-Jiao Shi, Shu-qin Ding, Lin Shen, Rui Wang, Qiyi Wang, Cheng Zha, Hai Ding, Jian-Guo Hu, He-zuo Lü   +10 more
semanticscholar   +1 more source

Russian VX: Inhibition and Reactivation of Acetylcholinesterase Compared with VX Agent [PDF]

Basic & Clinical Pharmacology & Toxicology, 2006
Abstract: Organophosphorus compounds such as nerve agents inhibit, practically irreversibly, cholinesterases by their phosphorylation in the active site of these enzymes. Current antidotal treatment used in the case of acute nerve agent intoxications consists of combined administration of anticholinergic drug (usually atropine) and acetylcholinesterase
Kamil, Kuca, Daniel, Jun, Jiri, Cabal, Martina, Hrabinova, Lucie, Bartosova, Veronika, Opletalova   +5 more
openaire   +2 more sources

Modeling radiation belt radial diffusion in ULF wave fields: 2. Estimating rates of radial diffusion using combined MHD and particle codes [PDF]

, 2010
[1] Quantifying radial transport of radiation belt electrons in ULF wave fields is essential for understanding the variability of the trapped relativistic electrons.
Elkington, Scot R., Huang, Chia-Lin L., Hudson, Mary K., Spence, Harlan E.   +3 more
core   +2 more sources

The geometry of reaction norms yields insights on classical fitness functions for Great Lakes salmon. [PDF]

, 2020
Life history theory examines how characteristics of organisms, such as age and size at maturity, may vary through natural selection as evolutionary responses that optimize fitness.
Breck, James E, Lamberson, PJ, Low, Bobbi S, Rogers, Mark W, Rutherford, Edward S, Simon, Carl P   +5 more
core   +2 more sources