Results 51 to 60 of about 252,763 (309)

Identification of binding sites for ivacaftor on the cystic fibrosis transmembrane conductance regulator

iScience, 2021
Summary: Ivacaftor (VX-770) was the first cystic fibrosis transmembrane conductance regulator (CFTR) modulatory drug approved for the treatment of patients with cystic fibrosis.
Onofrio Laselva, Zafar Qureshi, Zhi-Wei Zeng, Evgeniy V. Petrotchenko, Mohabir Ramjeesingh, C. Michael Hamilton, Ling-Jun Huan, Christoph H. Borchers, Régis Pomès, Robert Young, Christine E. Bear   +10 more
doaj   +1 more source

Clinical Activity of an hTERT-Specific Cancer Vaccine (Vx-001) in “Immune Desert” NSCLC

Cancers, 2021
Simple Summary We investigated whether there is any correlation between Vx-001 clinical activity and the tumor immune microenvironment (TIME). Our hypothesis was that Vx-001 should be clinically effective in patients with tumor-infiltrating lymphocyte ...
I. Pateras, A. Kotsakis, M. Avgeris, E. Baliou, Panagiotis Kouroupakis, E. Patsea, V. Georgoulias, Jeanne Menez-Jamet, J. Kinet, K. Kosmatopoulos   +9 more
semanticscholar   +1 more source

Quantum Phases in Partially Filled Landau Levels [PDF]

, 2004
We compare the energies of different electron solids, such as bubble crystals with triangular and square symmetry and stripe phases, to those of correlated quantum liquids in partially filled intermediate Landau levels. Multiple transitions between these
Goerbig, M. O., Lederer, P., Smith, C. Morais   +2 more
core   +2 more sources

Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. [PDF]

PLoS Neglected Tropical Diseases, 2010
Multiple cysteine proteases of malaria parasites are required for maintenance of parasite metabolic homeostasis and egress from the host erythrocyte. In Plasmodium falciparum these proteases appear to mediate the processing of hemoglobin and aspartic ...
Byoung-Kuk Na, Young-An Bae, Young-Gun Zo, Youngchool Choe, Seon-Hee Kim, Prashant V Desai, Mitchell A Avery, Charles S Craik, Tong-Soo Kim, Philip J Rosenthal, Yoon Kong   +10 more
doaj   +1 more source

Genetic parameters and genomic regions associated with piglet response to vaccination for porcine reproductive and respiratory syndrome (PRRS) virus and co-infection with PRRS virus and porcine circovirus type 2b (PCV2b) [PDF]

, 2016
Citation: Dunkelberger, J. R., Serao, N. V. L., Kerrigan, M. A., Lunney, J. K., Rowland, R. R. R., & Dekkers, J. C. M. (2016). Genetic parameters and genomic regions associated with piglet response to vaccination for porcine reproductive and respiratory ...
Dekkers, J. C. M., Dunkelberger, J. R., Kerrigan, M. A., Lunney, J. K., Rowland, Raymond R., Serao, N. V. L.   +5 more
core   +1 more source

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

Science Translational Medicine, 2019
In utero and early postnatal functional rescue of cystic fibrosis transmembrane conductance regulator improves survival in cystic fibrosis ferrets. Tackling cystic fibrosis in the womb Cystic fibrosis (CF) is a multiorgan disease caused by mutations in ...
Xingshen Sun, Y. Yi, Ziying Yan, B. H. Rosen, B. Liang, M. Winter, T. Evans, P. Rotti, Yu Yang, Jaimie S. Gray, Soo‐Yeun Park, Weihong Zhou, Yulong Zhang, S. Moll, Lisa Woody, Dao Tran, Licong Jiang, A. Vonk, J. Beekman, P. Negulescu, F. van Goor, D. Fiorino, K. Gibson-Corley, J. Engelhardt   +23 more
semanticscholar   +1 more source

Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX‐661 + VX‐770 treatment on disease severity

Journal of Physiology, 2021
Cystic fibrosis transmembrane conductance regulator (CFTR) has an essential role in maintaining pancreatic ductal function. Impaired CFTR function can trigger acute pancreatitis (AP) and exacerbate disease severity.
Gabriella Fűr, E. Bálint, E. Orján, Z. Balla, E. Kormányos, B. Czira, Attila Szűcs, Dénes Péter Kovács, P. Pallagi, J. Maléth, V. Venglovecz, P. Hegyi, L. Kiss, Z. Rakonczay   +13 more
semanticscholar   +1 more source

Do environmental quality standards for selected nerve agents ensure safety of the ecosystems? / Czy istniejące standardy jakości środowiska dla wybranych fosforoorganicznych bojowych środków trujących zapewniają również ochronę ekosystemów?

Environmental Protection and Natural Resources, 2013
Zagrożenie i ryzyko powodowane fosforoorganicznymi bojowymi środkami trującymi w stosunku do ludzi i organizmów wyższych jest stosunkowo dobrze rozpoznane i zbadane, jednakże dane naukowe dotyczące środowiskowego oddziaływania tego typu substancji są ...
Kalinowski Radosław, Chrzanowska Edyta, Brytan Marek   +2 more
doaj   +1 more source

Efficient agent degradation within skin is important for decontamination of percutaneously exposed VX

Cutaneous and Ocular Toxicology, 2021
Aim of the study Following percutaneous exposure to the nerve agent VX, the remaining intact agent within the skin after decontamination is of great concern.
L. Thors, E. Wigenstam, J. Qvarnström, A. Bucht   +3 more
semanticscholar   +1 more source

Application of 3D scanning technology in Royal Malaysian Air Force Industrial Revolution 4.0‐based aircraft maintenance

IET Networks, EarlyView., 2022
Abstract 3D scanning is rapidly becoming a key maintenance tool. Aerospace was a pioneer in adopting 3D scanning technology because aircraft manufacture and maintenance require precision. Monitoring deterioration, removing components for maintenance, and verifying covert operations are not practical or helpful without technology.
T. Nanthakumaran Thulasy, Puteri N. E. Nohuddin, Istas Fahrurrazi Nusyirwan, Mohd Hanafi Ahmad Hijazi, Musaddak Maher Abdul Zahra   +4 more
wiley   +1 more source