Results 141 to 150 of about 678,174 (319)

Modeling the Diffusion Coefficient of Charge Carriers in Metal Ion Batteries using the Randles‐Sevcik Equation

Advanced Theory and Simulations, EarlyView.
The development of multivalent rechargeable batteries (MRB) requires the prediction of battery behavior at experimentally unreached conditions in the laboratory. Therefore, the diffusion equation is used to analyze the relation between the diffusion coefficient (DC) and the Warburg factor for different MRBs to predict the theoretical DC values at ...
Eman I. Abd El‐Latif, Mesfin Abayneh Kebede, Karthick Sekar, Talaat A. Hameed, Ibrahim S. Yahia, Hongcai Gao, Eslam Sheha   +6 more
wiley   +1 more source

Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]

, 2016
© The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ, Crossey, MM, Fye, HK, Gomez-Romero, M, Holmes, E, Kim, JU, Njie, R, Shariff, MI, Taylor-Robinson, SD   +8 more
core   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

The Mitochondrial Warburg Effect: A Cancer Enigma

Interdisciplinary Bio Central, 2009
"To be, or not to be?" This question is not only Hamlet`s agony but also the dilemma of mitochondria in a cancer cell. Cancer cells have a high glycolysis rate even in the presence of oxygen. This feature of cancer cells is known as the Warburg effect, named for the first scientist to observe it, Otto Warburg, who assumed that because of mitochondrial ...
Taeho Kim, Euiyong Kim, Hyun Joo, Hans H. Kim, Seok-Ju Park, Ji Kyoung Park, Han Jip Kim   +6 more
openaire   +2 more sources

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Acta Pharmaceutica Sinica B
Cancer reprogramming is an important facilitator of cancer development and survival, with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation, even under sufficient oxygen supply condition.
Minru Liao, Dahong Yao, Lifeng Wu, Chaodan Luo, Zhiwen Wang, Jin Zhang, Bo Liu   +6 more
doaj  

Predictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression

BMC Medical Genomics
Background The Warburg effect is a hallmark characteristic of colorectal cancer (CRC). Despite extensive research, the role of long non-coding RNAs (lncRNAs) in influencing the Warburg effect remains incompletely understood.
Rui Mao, Chenxin Xu, Quanzheng Zhang, Zheng Wang, Yanjun Liu, Yurui Peng, Ming Li   +6 more
doaj   +1 more source

P2X7 Receptor: Warburg effect revisited [PDF]

, 2012
Ability to adapt to conditions of limited nutrient supply is a key feature of all cells. This may require a complex re-organization of metabolic pathways to balance energy generation and production of biosynthetic intermediates.
Amoroso, Francesca Saveria
core  

Multi-scale computational study of the Warburg effect, reverse Warburg effect and glutamine addiction in solid tumors

PLOS Computational Biology, 2018
Cancer metabolism has received renewed interest as a potential target for cancer therapy. In this study, we use a multi-scale modeling approach to interrogate the implications of three metabolic scenarios of potential clinical relevance: the Warburg effect, the reverse Warburg effect and glutamine addiction.
Mengrou Shan, David Dai, Arunodai Vudem, Jeffrey D. Varner, Abraham D. Stroock   +4 more
openaire   +5 more sources

Copy Number Gains of VPS72 Drive De Novo Lipogenesis and Hepatocarcinogenesis via ATF3/mTORC1/SREBP1 Axis

Advanced Science, EarlyView.
VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang, Yunxing Huang, Yin Tong, Kenneth Tsz Chun Ng, Jiangwen Zhang   +4 more
wiley   +1 more source