Results 21 to 30 of about 212,786 (294)
Identification of Key Genes and Pathways Associated With Endometriosis by Weighted Gene Co-Expression Network Analysis [PDF]
SSRN Electronic Journal, 2021 Background: Endometriosis is a common gynecological disorder with high rates of infertility and pelvic pain. However, its pathogenesis and diagnostic biomarkers remain unclear. This study aimed to elucidate potential hub genes and key pathways associated with endometriosis in ectopic endometrium (EC) and eutopic endometrium (EU).
Wu, Jingni +2 more
openaire +2 more sources
BMC Cardiovascular Disorders, 2021 Background Aneurysm is a severe and fatal disease. This study aims to comprehensively identify the highly conservative co-expression modules and hub genes in the abdominal aortic aneurysm (AAA), thoracic aortic aneurysm (TAA) and intracranial aneurysm ...
Siwei Bi +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Background: Cancer-associated fibroblasts (CAFs) are the most prominent cellular components in gastric cancer (GC) stroma that contribute to GC progression, treatment resistance, and immunosuppression.
Hang Zheng +4 more
semanticscholar +1 more source
Distance correlation application to gene co-expression network analysis
BMC Bioinformatics, 2022 Background To construct gene co-expression networks, it is necessary to evaluate the correlation between different gene expression profiles. However, commonly used correlation metrics, including both linear (such as Pearson’s correlation) and monotonic ...
Jie Hou +7 more
doaj +1 more source
Scientific Reports, 2021 The exponential growth in knowledge has resulted in a better understanding of the lactation process in a wide variety of animals. However, the underlying genetic mechanisms are not yet clearly known.
M. Farhadian +3 more
semanticscholar +1 more source
Rice Science, 2022 Zinc (Zn) malnutrition is a major public health issue. Genetic biofortification of Zn in rice grain can alleviate global Zn malnutrition. Therefore, elucidating the genetic mechanisms regulating Zn deprivation response in rice is essential to identify ...
Blaise Pascal Muvunyi +4 more
doaj +1 more source
Identification of PDK4 as Hub Gene for Diabetic Nephropathy Using Co-Expression Network Analysis
Kidney & Blood Pressure Research, 2023 Introduction: Diabetic nephropathy (DN) is related to type 1 and type 2 diabetes. They are the leading cause of end-stage renal disease, but the underling specific pathogenesis of DN is not yet clear. Our study was conducted to explore how DN changed the
Yuanyuan Han +4 more
doaj +1 more source
Hub genes of stroke identified by weighted gene co-expression network analysis [PDF]
, 2019 Abstract Background Microarray-based gene expression profiling has been widely used in biomedical research. Weighted gene co-expression network analysis (WGCNA) can link microarray data directly to clinical traits and to identify rules for predicting pathological stage and prognosis of disease, it has been found useful in many biological ...
Junhong Li +6 more
openaire +2 more sources
Cancers, 2019 Non-small-cell lung cancer (NSCLC) represents a heterogeneous group of malignancies consisting essentially of adenocarcinoma (ADC) and squamous cell carcinoma (SCC). Although the diagnosis and treatment of ADC and SCC have been greatly improved in recent
Magdalena Niemira +8 more
semanticscholar +1 more source
Identification of Hub Genes and Potential ceRNA Networks of Diabetic Nephropathy by Weighted Gene Co-Expression Network Analysis [PDF]
Frontiers in Genetics, 2021 Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients, and is the main cause of end-stage renal disease. The exact molecular mechanism of DN is not fully understood. The aim of this study was to identify novel biomarkers and mechanisms for DN disease progression by weighted gene co-expression network ...
Guoqing Li +9 more
openaire +3 more sources