Results 31 to 40 of about 148,880 (283)
Pharmacogenomics and Personalized Medicine, 2021 Xiaoxue Xu,1 Yuehan Hao,1 Jiao Wu,2 Jing Zhao,1 Shuang Xiong3 1Department of Neurology, The First Hospital of China Medical University, Shenyang, People’s Republic of China; 2Department of Neurology, The People’s Hospital of Liaoning Province,
Xu X, Hao Y, Wu J, Zhao J, Xiong S
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BMC Nephrology, 2021 Background Diabetic nephropathy (DN) is the major complication of diabetes mellitus, and leading cause of end-stage renal disease. The underlying molecular mechanism of DN is not yet completely clear.
Alieh Gholaminejad +2 more
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Gene expression in large pedigrees: analytic approaches. [PDF]
, 2016 BackgroundWe currently have the ability to quantify transcript abundance of messenger RNA (mRNA), genome-wide, using microarray technologies. Analyzing genotype, phenotype and expression data from 20 pedigrees, the members of our Genetic Analysis ...
Cantor, Rita M, Cordell, Heather J
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Experimental Biology and Medicine, 2023 Pulmonary hypertension (PH) is a cardiopulmonary vascular disease that acutely endangers human health and can be fatal. It progresses rapidly and has a high mortality rate. Its pathophysiology is complicated and still not completely elucidated; therefore, achieving treatment breakthroughs are difficult.
Shengyan Wang +6 more
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Identification of Infertility-Associated Topologically Important Genes Using Weighted Co-expression Network Analysis [PDF]
Frontiers in Genetics, 2021 Endometriosis has been associated with a high risk of infertility. However, the underlying molecular mechanism of infertility in endometriosis remains poorly understood. In our study, we aimed to discover topologically important genes related to infertility in endometriosis, based on the structure network mining.
Jingni Wu +5 more
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Journal of Integrative Bioinformatics, 2021 Connecting transcriptional and post-transcriptional regulatory networks solves an important puzzle in the elucidation of gene regulatory mechanisms. To decipher the complexity of these connections, we build co-expression network modules for mRNA as well ...
Wani Nisar, Barh Debmalya, Raza Khalid
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Frontiers in Genetics, 2021 Improving the understanding of the molecular mechanism of tuberculous pleurisy is required to develop diagnosis and new therapy strategies of targeted genes. The purpose of this study is to identify important genes related to tuberculous pleurisy.
Lei Shi +4 more
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An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks [PDF]
, 2017 Background: Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used R software package for the generation of gene co-expression networks (GCN). WGCNA generates both a GCN and a derived partitioning of clusters of genes (modules).
Botía, JA +9 more
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Frontiers in Oncology, 2021 BackgroundGastric cancer (GC) is one of the most common cancers all over the world, causing high mortality. Gastric cancer screening is one of the effective strategies used to reduce mortality. We expect that good biomarkers can be discovered to diagnose
Meng-jie Shan +7 more
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Modeling the functional genomics of autism using human neurons. [PDF]
, 2012 Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation,
Chen, L +10 more
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