Results 41 to 50 of about 61,812 (253)

The Role of Vitamin D in the Transcriptional Program of Human Pregnancy. [PDF]

PLoS ONE, 2016
Patterns of gene expression of human pregnancy are poorly understood. In a trial of vitamin D supplementation in pregnant women, peripheral blood transcriptomes were measured longitudinally on 30 women and used to characterize gene co-expression networks.
Amal Al-Garawi, Vincent J Carey, Divya Chhabra, Hooman Mirzakhani, Jarrett Morrow, Jessica Lasky-Su, Weiliang Qiu, Nancy Laranjo, Augusto A Litonjua, Scott T Weiss   +9 more
doaj   +1 more source

WGCNA: an R package for weighted correlation network analysis

BMC Bioinformatics, 2008
Background Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns among genes across microarray ...
Horvath Steve, Langfelder Peter
doaj   +1 more source

Construction of a prediction model for metastasis in gastric cancer based on the weighted gene co-expression network analysis

Zhongguo aizheng zazhi, 2021
Background and purpose: This study aimed to screen out the bio-markers related to the occurrence and metastasis of gastric cancer. The weighted gene co-expression network analysis (WGCNA) was performed to analyze the gene chips containing metastatic ...
龚　超, 陈　魁, 章德昆, 谢径峰, 吴芳华, 黄玉钿, 薛玉钦, 王力群   +7 more
doaj  

Using weighted gene co-expression network analysis to identify key genes related to preeclampsia. [PDF]

Front Immunol
IntroductionThe pathogenesis of preeclampsia remains unclear, highlighting the need for the creation of dependable biomarkers. This study aimed to pinpoint genetic risk factors linked to preeclampsia through the utilization of weighted gene co-expression network analysis (WGCNA).MethodsA gene expression profile dataset from the placentas of patients ...
Shen X, Zeng Z, Xie L, Yue X, Wang Z.
europepmc   +4 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Weighted gene co-expression network analysis reveals the hub genes and molecular mechanism of quiescence. [PDF]

3 Biotech
The hematopoietic stem cell (HSC) continues their functional integrity and return to quiescence quickly even after inflammatory and other proliferative stress. The mechanism which is responsible for this highly regulatory process is not understood clearly.
Apoorvha JP, Brindha S, Ganesan M, Roy S.   +3 more
europepmc   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Identification of hub genes in liver hepatocellular carcinoma based on weighted gene co-expression network analysis

Biochemical Genetics, 2023
Abstract Methods: Our study mainly used The Cancer Genome Atlas (TCGA) LIHC database and the gene expression profiles of GSE54236 from the Gene Expression Omnibus (GEO) to explore the differential co-expression genes between LIHC and normal tissues.
Sun, Jiawei, Zhang, Zizhen, Cai, Jiaru, Li, Xiaoping, Xu, Xiaoling   +4 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium

Molecular Medicine Reports, 2018
Acute myocardial infarction induces ventricular remodeling, which is implicated in dilated heart and heart failure. The pathogenical mechanism of myocardium remodeling remains to be elucidated. The aim of the present study was to identify key genes and networks for myocardium remodeling following ischemia‑reperfusion (IR).
Guo, Nan, Zhang, Nan, Yan, Liqiu, Lian, Zheng, Wang, Jiawang, Lv, Fengfeng, Wang, Yunfei, Cao, Xufen   +7 more
openaire   +3 more sources