Results 41 to 50 of about 69,571 (187)

Identification of Hub Genes Associated With Tuberculous Pleurisy by Integrated Bioinformatics Analysis

Frontiers in Genetics, 2021
Improving the understanding of the molecular mechanism of tuberculous pleurisy is required to develop diagnosis and new therapy strategies of targeted genes. The purpose of this study is to identify important genes related to tuberculous pleurisy.
Lei Shi, Zilu Wen, Hongwei Li, Yanzheng Song, Yanzheng Song   +4 more
doaj   +1 more source

Screening and Identification of Key Biomarkers of Gastric Cancer: Three Genes Jointly Predict Gastric Cancer

Frontiers in Oncology, 2021
BackgroundGastric cancer (GC) is one of the most common cancers all over the world, causing high mortality. Gastric cancer screening is one of the effective strategies used to reduce mortality. We expect that good biomarkers can be discovered to diagnose
Meng-jie Shan, Meng-jie Shan, Ling-bing Meng, Ling-bing Meng, Peng Guo, Yuan-meng Zhang, Dexian Kong, Ya-bin Liu   +7 more
doaj   +1 more source

Discovery of core genes in colorectal cancer by weighted gene co‑expression network analysis

Oncology Letters, 2019
The aim of the present study was to investigate the interactions among messenger RNAs (mRNAs), microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) in colorectal cancer (CRC), in order to examine its underlying mechanisms. The raw gene expression data was downloaded from the Gene Expression Omnibus (GEO) database. An online tool, GEO2R, which is based
Liao, Cun, Huang, Xue, Gong, Yizhen, Lin, Qiuning   +3 more
openaire   +3 more sources

Weighted gene co-expression network analysis reveals the hub genes associated with pulmonary hypertension

Experimental Biology and Medicine, 2023
Pulmonary hypertension (PH) is a cardiopulmonary vascular disease that acutely endangers human health and can be fatal. It progresses rapidly and has a high mortality rate. Its pathophysiology is complicated and still not completely elucidated; therefore, achieving treatment breakthroughs are difficult.
Shengyan Wang, Dejun Sun, Chuanchuan Liu, Yong Guo, Jie Ma, Ri-li Ge, Sen Cui   +6 more
openaire   +2 more sources

Treatment-associated mRNA co-expression changes in monocytes of patients with posttraumatic stress disorder

Frontiers in Psychiatry, 2023
PTSD is a prevalent mental disorder that results from exposure to extreme and stressful life events and comes at high costs for both the individual and society.
Robert Kumsta, Robert Kumsta, Johannes C. S. Zang, Elisabeth M. Hummel, Svenja Müller, Dirk A. Moser, Stephan Herpertz, Henrik Kessler, Henrik Kessler   +8 more
doaj   +1 more source

Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer [PDF]

Journal of Ovarian Research, 2020
Abstract Background : WTAP modulating other genes in the manner of transcriptional and post-transcriptional regulation, in particular, acting as a N6-methyladenosine writer or binding to the 3’-untranslated region of mRNA, promotes a variety of tumors. However, its roles and mechanisms in ovarian cancer are unknown.
Jing Wang, Jing Xu, Ke Li, Yunke Huang, Yilin Dai, Congjian Xu, Yu Kang   +6 more
openaire   +3 more sources

Identification of Key Modules and Hub Genes Involved in Regulating the Color of Chicken Breast Meat Using WGCNA

Animals, 2023
Meat color is one of the most important economic traits in chickens. However, the gene network and regulatory mechanisms contributing to meat color traits in chickens remain largely unknown.
Xing Guo, Hong Zhang, Hao Wang, Xin-Xin He, Jiang-Xian Wang, Wei Wei, Meng Liu, Jin-Mei Xu, Ya-Nan Liu, Run-Shen Jiang   +9 more
doaj   +1 more source

CD36 identified by weighted gene co-expression network analysis as a hub candidate gene in lupus nephritis [PDF]

PeerJ, 2019
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE), which often progresses to end-stage renal disease (ESRD) and ultimately leads to death.
Huiying Yang, Hua Li
doaj   +2 more sources

Identifying key genes in milk fat metabolism by weighted gene co-expression network analysis

Scientific Reports, 2022
AbstractMilk fat is the most important and energy-rich substance in milk, and its content and composition are important reference elements in the evaluation of milk quality. However, the current identification of valuable candidate genes affecting milk fat is limited.
Tong Mu, Honghong Hu, Yanfen Ma, Huiyu Wen, Chaoyun Yang, Xiaofang Feng, Wan Wen, Juan Zhang, Yaling Gu   +8 more
openaire   +3 more sources

Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date

BMC Genomics, 2021
Background Wheat is one of the most widely planted crops worldwide. The heading date is important for wheat environmental adaptability, as it not only controls flowering time but also determines the yield component in terms of grain number per spike ...
Yuxin Yang, Xueying Zhang, Lifen Wu, Lichao Zhang, Guoxiang Liu, Chuan Xia, Xu Liu, Xiuying Kong   +7 more
doaj   +1 more source