Mitochondrial dysfunction in white adipose tissue [PDF]
Trends in Endocrinology & Metabolism, 2012 Although mitochondria in brown adipose tissue and their role in non-shivering thermogenesis have been widely studied, we have only a limited understanding of the relevance of mitochondria in white adipose tissue (WAT) for cellular homeostasis of the adipocyte and their impact upon systemic energy homeostasis.
Christine M. Kusminski +1 more
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Sexual Dimorphism in Brown Adipose Tissue Activation and White Adipose Tissue Browning
International Journal of Molecular Sciences, 2022 The present narrative review gathers the studies reported so far, addressing sex differences in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. In rodents, when exposed to decreasing temperatures, females activate thermogenesis earlier. Results obtained in humans
Iker Gómez-García +4 more
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Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology [PDF]
, 2016 To view supplementary material for this article, please visit http://dx.doi.org/10.1017/S1751731116000872Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of ...
Bonnet, Muriel +3 more
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White adipose tissue mitochondrial metabolism in health and in obesity [PDF]
, 2020 White adipose tissue is one of the largest organs of the body. It plays a key role in whole-body energy status and metabolism; it not only stores excess energy but also secretes various hormones and metabolites to regulate body energy balance.
Christe M +6 more
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Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]
, 2015 BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L. +9 more
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Hypoxia and adipose tissue function and dysfunction in obesity [PDF]
, 2013 The rise in the incidence of obesity has led to a major interest in the biology of white adipose tissue. The tissue is a major endocrine and signalling organ, with adipocytes, the characteristic cell type, secreting a multiplicity of protein factors ...
Di Girolamo M +12 more
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Development of brown and white adipose tissue
Journal of Lipid Research, 1975 In this review, it is assumed that the reader is familiar with the basic properties of white and brown adipose tissue. The role and metabolic characteristics of both tissues in adult mammals have been adequately and repeatedly reviewed (1-3) and will be mentioned here only insofar as they impinge upon developmental aspects. Macroscopically brown fat is
Peter Hahn, Milan Novák
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The regulation of adipocyte growth in white adipose tissue
Frontiers in Cell and Developmental Biology, 2022 Adipocytes can increase in volume up to a thousand-fold, storing excess calories as triacylglycerol in large lipid droplets. The dramatic morphological changes required of adipocytes demands extensive cytoskeletal remodeling, including lipid droplet and plasma membrane expansion.
Li, Qian, Spalding, Kirsty L.
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Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]
, 2016 Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P. +10 more
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Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]
, 2007 *Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky +17 more
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