Results 71 to 80 of about 388,905 (379)

Mesenchymal stem cells: A novel treatment option for primary sclerosing cholangitis

Cell Biology International, Volume 47, Issue 2, Page 467-479, February 2023., 2023
Abstract Primary sclerosing cholangitis (PSC) is a progressive liver disease for which there is no effective therapy. Hepatocytes and cholangiocytes from a PSC patient were cocultured with mesenchymal stem cells (MSCs) to assess in vitro change. A single patient with progressive PSC was treated with 150 million MSCs via direct injection into the common
Amy L. Lightner, Neda Dadgar, Anil Vaidya, Robert Simon, Clifton Fulmer, Hassan Siddiki, K. V. Narayanan Menon, Peter Liu, R. Matthew Walsh   +8 more
wiley   +1 more source

Characterization of breast tissues in density and effective atomic number basis via spectral X-ray computed tomography [PDF]

, 2023
Differentiation of breast tissues is challenging in X-ray imaging because tissues might share similar or even the same linear attenuation coefficients $\mu$. Spectral computed tomography (CT) allows for more quantitative characterization in terms of tissue density and effective atomic number by exploiting the energy dependence of $\mu$. In this work, 5
arxiv   +1 more source

Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning

Lipids in Health and Disease, 2018
Cancer cachexia is a progressive and multi-factorial metabolic syndrome characterized by loss of adipose tissue and skeletal muscle. White adipose tissue (WAT) lipolysis and white-to-brown transdifferentiation of WAT (WAT browning) are proposed to ...
Jun Han, Q. Meng, Lei Shen, Guohao Wu
semanticscholar   +1 more source

Adipose tissue knockdown of lysozyme reduces local inflammation and improves adipogenesis in high-fat diet-fed mice [PDF]

, 2021
Chronic systemic low-level inflammation in metabolic disease is known to affect adipose tissue biology. Lysozyme (LYZ) is a major innate immune protein but its role in adipose tissue has not been investigated.
Becerril, Sara, Comas, Ferran, Fernández-Real, José Manuel, Frühbeck, Gema, Gavaldà i Navarro, Aleix, Giralt i Oms, Marta, Latorre, Jèssica, Lluch, Aina, Moreno-Navarrete, José M., Morón-Ros, Samantha, Ortega, Francisco J., Ricart, Wifredo, Rodríguez, Amaia, Villarroya i Gombau, Francesc   +13 more
core   +1 more source

The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay

ChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022
The adipokine chemerin and the short peptide agonist chemerin‐9 activate two GPCRs: CMKLR1 and GPR1. Here, we established a nanoluciferase based binding assay to analyze differences in ligand binding. For GPR1, both ligands show high affinity and comparable binding.
Anne Sophie Czerniak, Kevin Kretschmer, Tina Weiß, Annette G. Beck‐Sickinger   +3 more
wiley   +1 more source

TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

Experimental and Molecular Medicine, 2023
Fat metabolism: protecting against obesity-related metabolic disorders Studying a protein called TGFBI, which regulates adipose expansion, may help the development of new approaches to protect against obesity and related metabolic disorders such as type ...
Seul Gi Lee, Jongbeom Chae, Seon Min Woo, Seung Un Seo, Ha-Jeong Kim, Sang-Yeob Kim, David D. Schlaepfer, In-San Kim, Hee-Sae Park, Taeg Kyu Kwon, Ju-Ock Nam   +10 more
doaj   +1 more source

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Frontiers in Endocrinology, 2023
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu, Xiaomeng Liu, Zhi Zhang, Zhi Zhang, Yajie Song, Hengchang Xie, Meng Dong, Meng Dong   +7 more
doaj   +1 more source

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

Nature Communications, 2018
Remodelling of energy storing white fat into energy expending beige fat could be a promising strategy to reduce adiposity. Here, we show that the bile acid-responsive membrane receptor TGR5 mediates beiging of the subcutaneous white adipose tissue (scWAT)
L. Velázquez-Villegas, A. Perino, Vera Lemos, Marika Ziętak, Mitsunori Nomura, T. W. Pols, K. Schoonjans   +6 more
semanticscholar   +1 more source

Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]

, 2015
BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L., Dixen, Karen, Gupta, Ramneek, Hansen, Jacob B., Kristiansen, Karsten, Quistorff, Bjorn, Qvortrup, Klaus, Tygesen, Malin P., Wang, Jun, Yadav, Rachita   +9 more
core   +3 more sources

White adipose tissue as a target for cadmium toxicity

Frontiers in Pharmacology, 2022
Cadmium (Cd) is a widespread heavy metal known as a toxic environmental pollutant. Cd exposure is threatening due to its bioaccumulation trait in living systems that exceeds 35 years without a beneficial biological role. Acute exposure to high Cd doses was reported to impact adipose tissue (AT) function adversely.
Sarra Mohammed Attia, Sarra Mohammed Attia, Sandra Concepcion Das, Sandra Concepcion Das, Kavitha Varadharajan, Hamda A. Al-Naemi, Hamda A. Al-Naemi   +6 more
openaire   +3 more sources