Evaluating anticancer properties of Withaferin A—a potent phytochemical
Frontiers in Pharmacology, 2022 Withaferin A is a C28 steroidal lactone derived from the plant Withania somnifera, commonly known as Ashwagandha. Withaferin A has received great attention for its anticancer properties noted in cancer cells of various origins.
Maushma Atteeq
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Withaferin A Associated Differential Regulation of Inflammatory Cytokines [PDF]
Frontiers in Immunology, 2018 A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary ...
Dev Karan +2 more
exaly +5 more sources
Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective [PDF]
Antioxidants, 2020 Chronic inflammatory diseases are considered to be one of the biggest threats to human health. Most prescribed pharmaceutical drugs aiming to treat these diseases are characterized by side-effects and negatively affect therapy adherence.
Wim Vanden Berghe +2 more
exaly +6 more sources
Cells, 2022 Background: Retinal ischemia-reperfusion (I/R) injury often results in intractable visual impairments. The survival of retinal capillary endothelial cells is crucial for the treatment of retinal I/R injury.
Zheyi Yan +6 more
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Withaferin A ameliorates ovarian cancer-induced cachexia and proinflammatory signaling
Journal of Ovarian Research, 2019 Background Ovarian cancer is the fifth leading cause of cancer-related deaths amongst women in the United States. Cachexia is the primary cause of death in approximately 30% of cancer patients, and is often evidenced in ovarian cancer patients. We tested
Alex R. Straughn, Sham S. Kakar
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Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition. [PDF]
PLoS ONE, 2013 Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastatic ...
Zhen Yang +6 more
doaj +3 more sources
Withaferin A inhibits osteosarcoma cells through inactivation of Notch-1 signalling [PDF]
Bangladesh Journal of Pharmacology, 2014 Human osteosarcoma cells were treated with withaferin A and the antiproliferative activity was evaluated by the 3-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays.
Yang Chen +4 more
doaj +2 more sources
Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis
Archives of Medical ScienceIntroduction Withaferin-A (WA) derived from natural products can inhibit the growth and metastasis of colorectal cancer (CRC) in vitro and in vivo. Transcriptome sequencing showed that WA inhibited the epithelial-mesenchymal transition pathway (EMT ...
Wen-qi Lu +6 more
doaj +2 more sources
Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
Biomedicines, 2020 Withaferin A (WA), a manifold studied, C28-steroidal lactone withanolide found in Withania somnifera. Given its unique beneficial effects, it has gathered attention in the era of modern science.
Lalit Sharma +2 more
exaly +3 more sources
Cytotoxic Potential Evaluation of Innovative Pressurised Cyclic Solid–Liquid Extracts from Withania somnifera [PDF]
PlantsEthnopharmacological relevance. Withania somnifera (L.) Dunal, widely used in traditional medical systems such as Ayurveda, Unani, and Middle Eastern folk medicine, is valued for its adaptogenic, anti-inflammatory, neuroprotective, antimicrobial, and ...
Rosanna Culurciello +9 more
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