Results 71 to 80 of about 114,628,403 (161)
MedComm, Volume 7, Issue 9, September 2026.Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan +9 more
wiley +1 more source
p53, a target of withanone and withaferin A.
, 2013 Docking of withanone (Wi-N) (A) and withaferin A (Wi-A) (B) to p53. (C) Imaging of p53 in human cancer (U2OS) cells treated with various concentrations of Wi-N and Wi-A.
M. Uthayakumar (308967) +9 more
core +1 more source
Ferroptosis: Newly Emerged Regulator for Human Disease
MedComm, Volume 7, Issue 9, September 2026.Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao +4 more
wiley +1 more source
MedComm – Oncology, Volume 5, Issue 3, September 2026.Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
wiley +1 more source
Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis
Introduction Withaferin-A (WA) derived from natural products can inhibit the growth and metastasis of colorectal cancer (CRC) in vitro and in vivo. Transcriptome sequencing showed that WA inhibited the epithelial-mesenchymal transition pathway (EMT ...
Chun-ming Wang +6 more
core +1 more source
Withaferin A Suppresses Liver Tumor Growth in a Nude Mouse Model by Downregulation of Cell Signaling Pathway Leading to Invasion and Angiogenesis [PDF]
, 2015 Purpose: To investigate the effect of withaferin A on tumor growth and metastasis in liver in a nude mouse model.Methods: Withaferin A was injected through a portal vein to the orthotopic liver tumor in a nude mice model.
Wang, YX, Dong, CW, Ding, WB
core +1 more source
eFood, Volume 7, Issue 4, August 2026.Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch +11 more
wiley +1 more source
Genetic and Withaferin A Analysis of Iranian Natural Populations of and by RAPD and HPTLC
Natural Product Communications, 2009 For successful conservation and breeding of a medicinal species, it is important to evaluate its genetic diversity as well as its content of phytochemical compounds. The aim of the present study was to investigate the genetic variation of Iranian natural
Mohammad Hossein Mirjalili +4 more
doaj +1 more source
Biomolecular ConceptsTriple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer. Due to the absence of obvious therapeutic targets, microRNAs (miRNAs) provide possible hope to treat TNBC.
Shuaib Mohd +2 more
doaj +1 more source
Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective
Antioxidants, 2020 Chronic inflammatory diseases are considered to be one of the biggest threats to human health. Most prescribed pharmaceutical drugs aiming to treat these diseases are characterized by side-effects and negatively affect therapy adherence.
Emilie Logie, Wim Vanden Berghe
doaj +1 more source