Results 71 to 80 of about 3,286 (169)

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

Molecular Cancer, 2010
Background Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 and Nrf2 transcription factors. In
Gerlo Sarah, Zhokhov Sergey, Palagani Ajay, Poompimon Wilart, Mankhetkorn Samlee, Suttana Wipob, Haegeman Guy, Berghe Wim   +7 more
doaj   +1 more source

Glioblastoma Stem Cells and Withaferin A, A Review [PDF]

Biomedical Journal of Scientific & Technical Research, 2019
Glioblastoma multiforme is characterized by tumor cell heterogeneity, and by recurrent invasive tumors following conventional radiation, cytotoxic drugs, and limited ablative surgery [1-5]...
openaire   +1 more source

Withaferin A decreases glycolytic reprogramming in breast cancer

Scientific Reports
Reprogrammed glucose metabolism is considered as the hallmark of cancer with therapeutic implications. Phytocompounds have potential to inhibit cancer metabolism. Here, we tested the ability of Withaferin A (WA), a withanolide derived from Withania somnifera, in modulating cancer metabolism.
Asifa Khan, Asad ur Rehman, Shumaila Siddiqui, Jiyauddin Khan, Sheersh Massey, Prithvi Singh, Daman Saluja, Syed Akhtar Husain, Mohammad Askandar Iqbal   +8 more
openaire   +3 more sources

In Silico Identification of Plant-Derived GPX4 Inhibitors as Potential Ferroptosis Inducers: Molecular Docking, Dynamics, and ADMET Studies

Current Issues in Molecular Biology
This study aims identify plant-derived compounds that can inhibit glutathione peroxidase 4 (GPX4) enzyme and evaluate them through molecular docking, dynamics simulations, and ADMET analyses.
Şerife Efsun Antmen, Hasan Öz, Cem Yalaza, Necmiye Canacankatan   +3 more
doaj   +1 more source

Implications of Withaferin A in neurological disorders

Neural Regeneration Research, 2020
Natasha Ram, Stephanie L. Peak, Andres R. Perez, Umesh K. Jinwal   +3 more
openaire   +3 more sources

Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption

Scientific Reports
Gastric cancer is highly lethal due to late-stage diagnosis and resistance to standard treatments like radiotherapy. Enhancing radiosensitivity in gastric cancer cells could improve treatment outcomes.
Ping Lu, Juan Xue, Xuemeng JI
doaj   +1 more source

Therapeutic Potential of Withaferin-A and Propolis Combinational Drug Therapy for Breast Cancer: An In Vivo Interpretation for Validating the Antiproliferative Efficacy and Ameliorative Potential in Benzo[a]pyrene-Induced Breast Metastasis

Journal of Chemistry
Cancer is a serious health problem, with a rising trend in its occurrence documented globally. Female breast cancer is the most common type of cancer worldwide with treatment consisting of different strategies like mastectomy, chemotherapy, and ...
Meghalatha T. S., Arumugam Suresh, Muninathan Natrajan, Kuppusamy Baskaran, Shobana Sampath, Elumalai Perumal, E. Madhav, Mohammad Z. Ahmed, Ali S. Alqahtani, Shadab Kazmi, Asaithambi Perumal   +10 more
doaj   +1 more source

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

BMC Bioinformatics, 2011
Background Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and ...
Grover Abhinav, Agrawal Vibhuti, Shandilya Ashutosh, Bisaria Virendra S, Sundar Durai   +4 more
doaj   +1 more source

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression

Journal of Experimental & Clinical Cancer Research
Background Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan, Nannan Zhang, Xueni Fu, Xinyu Wang, Yichun Ma, Qi Chen, Yue Zhou, Hongwen Liu, Yun Zhu, Lei Xu, Qiang Wang, Dongyin Chen, Zhangding Wang, Lei Wang   +13 more
doaj   +1 more source