Results 71 to 80 of about 4,082 (209)
Frontiers in Medicine, 2017 Visceral leishmaniasis (VL) causes fatal life-threatening disease, if left untreated. The current drugs have various limitations; hence, natural products from medicinal plants are being focused in search of new drugs to treat leishmaniasis.
Sambamurthy Chandrasekaran +3 more
doaj +1 more source
A comprehensive review of cancer‐induced cardiac wasting
British Journal of Pharmacology, EarlyView.Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena +5 more
wiley +1 more source
Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective
RSC Medicinal Chemistry, 2020 A review discussing the broad-spectrum antitumor properties of the natural steroid Withaferin A based on the binding with its true cancer protein targets: a defined stress dependent and stress independent mode of action.
Martin Dom +2 more
openaire +4 more sources
Rapid and sensitive method for determination of withaferin-A in human plasma by HPLC
, 2011 Background: To develop and validate a rapid and sensitive high-performance liquid chromatographic method for determination of withaferin-A in human plasma.
Pankaj Patial, Vikram Gota
core +1 more source
MedComm – Oncology, Volume 5, Issue 3, September 2026.Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
wiley +1 more source
ISOLATION AND CHARACTERIZATION OF WITHAFERIN-A FROM THE WITHANIA SOMNIFERA (ASHWAGANDHA)
, 2017 The research work is related to an improved process of isolation & characterization of Withaferin-A from withania somnifera (Sanskrit: Ashawagandha, English: Winter cherry).
Rakesh Kumar Jat +3 more
core +1 more source
Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice [PDF]
Nature Medicine, 2016 The increasing global prevalence of obesity and its associated disorders points to an urgent need for the development of novel and effective therapeutic strategies that induce healthy weight loss. Obesity is characterized by hyperleptinemia and central leptin resistance.
Lee, Jaemin +7 more
openaire +4 more sources
Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella +4 more
wiley +1 more source
Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer [PDF]
Cancer Research, 2014 Abstract Withaferin A (WFA) is a steroidal lactone with antitumor effects manifested at multiple levels that are mechanistically obscure. Using a phospho-kinase screening array, we discovered that WFA activated phosphorylation of the S6 kinase RSK (ribosomal S6 kinase) in breast cancer cells.
Arumugam, Nagalingam +4 more
openaire +2 more sources
Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis
Introduction Withaferin-A (WA) derived from natural products can inhibit the growth and metastasis of colorectal cancer (CRC) in vitro and in vivo. Transcriptome sequencing showed that WA inhibited the epithelial-mesenchymal transition pathway (EMT ...
Chun-ming Wang +6 more
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