Results 91 to 100 of about 4,082 (209)
Chemical structures of withanone and withaferin A.
, 2013 Withanone is a C6, C7 epoxy compound (colored red) that has hydroxyl groups (colored green) on C5 and C17. On the other hand, withaferin A is a C5, C6 epoxy compound (colored red) with hydroxyl groups on C4 and C27 (colored green).
M. Uthayakumar (308967) +9 more
core +1 more source
Supplementary Table from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors
, 2023 Supplementary Table from Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary ...
Krishna B. Singh (15111017) +3 more
core +1 more source
Withaferin A decreases glycolytic reprogramming in breast cancer
Scientific ReportsReprogrammed glucose metabolism is considered as the hallmark of cancer with therapeutic implications. Phytocompounds have potential to inhibit cancer metabolism. Here, we tested the ability of Withaferin A (WA), a withanolide derived from Withania somnifera, in modulating cancer metabolism.
Asifa Khan +8 more
openaire +3 more sources
The development of advanced high-capacity nanoparticle-based drug loading, precise targeting, low toxicity, and excellent biocompatibility is critical for improving cancer therapeutics.
Paulraj Arunkumar +2 more
core +1 more source
Withaferin A is a Leptin Sensitizer with Strong Anti-Diabetic Properties in Mice
, 2018 The increasing global prevalence of obesity and its associated disorders point to an urgent need for the development of novel and effective therapeutic strategies that induce healthy weight loss.
Lee, Jaemin +7 more
core +1 more source
Implications of Withaferin A in neurological disorders
Neural Regeneration Research, 2021 Natasha Ram +3 more
openaire +3 more sources
Glioblastoma Stem Cells and Withaferin A, A Review [PDF]
Biomedical Journal of Scientific & Technical Research, 2019 Glioblastoma multiforme is characterized by tumor cell heterogeneity, and by recurrent invasive tumors following conventional radiation, cytotoxic drugs, and limited ablative surgery [1-5]...
openaire +1 more source
Molecular Cancer, 2010 Background Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 and Nrf2 transcription factors. In
Gerlo Sarah +7 more
doaj +1 more source
Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach
, 2019 To cope with the poor aqueous solubility of withaferin A, a broad-spectrum anti-cancer agent effective against therapy-resistant cancers, a polymer-drug conjugate was synthesized via a grafting-from-drug approach.
Vanden Berghe, Tom +8 more
core +1 more source
, 2009 Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency and buccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
Panjamurthy, Kuppusamy +5 more
core +1 more source