Results 91 to 100 of about 114,628,403 (161)

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

Molecular Cancer, 2010
Background Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 and Nrf2 transcription factors. In
Gerlo Sarah, Zhokhov Sergey, Palagani Ajay, Poompimon Wilart, Mankhetkorn Samlee, Suttana Wipob, Haegeman Guy, Berghe Wim   +7 more
doaj   +1 more source

Withaferin A and Alzheimer\u27s Disease: A Review [PDF]

Alzheimer\u27s disease is characterized by the buildup of amyloid-beta (AB) protein in the brain, which disrupts brain function and leads to cognitive decline. Current research focuses on finding ways to reduce AB plaques.
Justice, Donovan, Joshi, Smita
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Withaferin-A: A Potential Anticancer Withanolide from Withania somnifera (L.) Dun. [PDF]

, 2003
Withania somnifera (Ashwagandha) is a plant used in medicine from the time of Ayurveda, the ancient system of Indian medicine. The dried roots of the plant are used in the treatment of nervous and sexual disorders.
Singh, Amrit Pal
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Apoptosis is Induced in leishmanial Cells by a Novel Protein Kinase Inhibitor Withaferin A and is Facilitated by Apoptotic Topoisomerase I–DNA complex

, 2007
Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. We report here that like staurosporine, withaferin A is a potent inhibitor of PKC.
Sen, T, Pramanik, S, Mukhopadhyay, S, Mukhopadhyay, S., H K Majumder, Sen, T., B Banerjee, Das, B. B., Banerjee, B, S Mukhopadhyay, Majumder, H. K., N Sen, Sen, N., B B Das, A Ganguly, Banerjee, B., Ganguly, A., Majumder, Hemanta K, Sen, N, Pramanik, S., Ganguly, A, T Sen, S Pramanik   +22 more
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Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction

, 2019
A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition.
Yogita H. Dahat (6536516), Meenakshi Singh (1645396), Yogesh P. Bharitkar (649975), Ramkrishna Mandal (6536510), Abhijit Hazra (385320), V. Ravichandiran (3864802), Amrutha A.V. Krishnan (6536513)   +6 more
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Therapeutic Potential of Withaferin-A and Propolis Combinational Drug Therapy for Breast Cancer: An In Vivo Interpretation for Validating the Antiproliferative Efficacy and Ameliorative Potential in Benzo[a]pyrene-Induced Breast Metastasis

Journal of Chemistry
Cancer is a serious health problem, with a rising trend in its occurrence documented globally. Female breast cancer is the most common type of cancer worldwide with treatment consisting of different strategies like mastectomy, chemotherapy, and ...
Meghalatha T. S., Arumugam Suresh, Muninathan Natrajan, Kuppusamy Baskaran, Shobana Sampath, Elumalai Perumal, E. Madhav, Mohammad Z. Ahmed, Ali S. Alqahtani, Shadab Kazmi, Asaithambi Perumal   +10 more
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Radiosensitizing effects of Withaferin A in gastric cancer cells via autophagy Inhibition and mitochondrial disruption

Scientific Reports
Gastric cancer is highly lethal due to late-stage diagnosis and resistance to standard treatments like radiotherapy. Enhancing radiosensitivity in gastric cancer cells could improve treatment outcomes.
Ping Lu, Juan Xue, Xuemeng JI
doaj   +1 more source

Radiosensitization of a mouse melanoma by withaferin A: In vivo studies

, 2000
432-437The radiosensitizing effect of a plant withanolide, withaferin A, on the B16F1 mouse melanoma was studied in vivo.Treatment of 100 mm3 tumours with 10 to 60 mg/kg withaferin A intraperitoneally produced a dose dependent increase in growth delay
Rao, B S Satish, Devi, P Uma, Kamath, Ravindra   +2 more
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Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

BMC Bioinformatics, 2011
Background Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and ...
Grover Abhinav, Agrawal Vibhuti, Shandilya Ashutosh, Bisaria Virendra S, Sundar Durai   +4 more
doaj   +1 more source

Mortalin, a target of withanone and withaferin A.

, 2013
Docking of withanone (Wi-N) (A) and withaferin A (Wi-A) (B) in the “latch region” of mortalin (PDB-id: 3N8E). (C) Quantitative analysis of mortalin in human cancer (U2OS) cells treated with various doses of Wi-N and Wi-A. (D) Imaging of mortalin in human
M. Uthayakumar (308967), Rumani Singh (185969), Sunil C. Kaul (186002), Nishant Saxena (308963), Shankar P. Kanaujia (308968), Kirti Vaishnavi (308960), Navjot Shah (308964), Kanagaraj Sekar (244392), Renu Wadhwa (185998), Kavyashree Manjunath (308966)   +9 more
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