Results 101 to 110 of about 4,082 (209)

Data from SILAC-based quantitative analysis of lysates from mouse microglial cells treated with Withaferin A (WA)

Data in Brief, 2016
Mass spectrometry data collected in a study analyzing the effect of withaferin A (WA) on a mouse microglial (N9) cell line is presented in this article.
Malathi Narayan, Kent W. Seeley, Umesh K. Jinwal   +2 more
doaj   +1 more source

Apoptosis is Induced in leishmanial Cells by a Novel Protein Kinase Inhibitor Withaferin A and is Facilitated by Apoptotic Topoisomerase I–DNA complex

, 2007
Protein kinase C (PKC) is an important constituent of the signaling pathways involved in apoptosis. We report here that like staurosporine, withaferin A is a potent inhibitor of PKC.
Sen, T, Pramanik, S, Mukhopadhyay, S, Mukhopadhyay, S., H K Majumder, Sen, T., B Banerjee, Das, B. B., Banerjee, B, S Mukhopadhyay, Majumder, H. K., N Sen, Sen, N., B B Das, A Ganguly, Banerjee, B., Ganguly, A., Majumder, Hemanta K, Sen, N, Pramanik, S., Ganguly, A, T Sen, S Pramanik   +22 more
core   +1 more source

Withaferin A Suppresses Liver Tumor Growth in a Nude Mouse Model by Downregulation of Cell Signaling Pathway Leading to Invasion and Angiogenesis

, 2015
Purpose: To investigate the effect of withaferin A on tumor growth and metastasis in liver in a nude mouse model.Methods: Withaferin A was injected through a portal vein to the orthotopic liver tumor in a nude mice model.
Wang, YX, Dong, CW, Ding, WB
core   +1 more source

Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology

International Journal of Molecular Sciences, 2019
Ashwagandha (Withania Somnifera, WS), belonging to the family Solanaceae, is an Ayurvedic herb known worldwide for its numerous beneficial health activities since ancient times. This medicinal plant provides benefits against many human illnesses such as epilepsy, depression, arthritis, diabetes, and palliative effects such as analgesic, rejuvenating ...
Dutta, Rinku, Khalil, Roukiah, Green, Ryan, Mohapatra, Shyam S, Mohapatra, Subhra   +4 more
openaire   +2 more sources

Semi-synthesis of a novel hybrid isoxazolidino withaferin via chemoselective and diastereoselective 1,3-dipolar nitrone cycloaddition reaction

, 2019
A facile, atom-economic synthesis of isoxazilidino withaferin, a novel hybrid of withaferin A, has been accomplished via two-step reaction of nitrone synthesis followed by nitrone 1,3-dipolar cycloaddition.
Yogita H. Dahat (6536516), Meenakshi Singh (1645396), Yogesh P. Bharitkar (649975), Ramkrishna Mandal (6536510), Abhijit Hazra (385320), V. Ravichandiran (3864802), Amrutha A.V. Krishnan (6536513)   +6 more
core   +1 more source

Withaferin A promotes proliferation and migration of brain endothelial cells

, 2016
Purpose: To investigate the effect of withaferin A (WFA) on the proliferation and migration of brain endothelial cells.Methods: BALB-5023 mouse microvascular cells were treated with a range of withaferin A (WFA) concentrations from 10 to 100 ng/mL ...
Huang, Li-An, Li, Tong, Wang, Zi-Jun, Jiang, Shan   +3 more
core   +1 more source

Withaferin A and Alzheimer\u27s Disease: A Review [PDF]

Alzheimer\u27s disease is characterized by the buildup of amyloid-beta (AB) protein in the brain, which disrupts brain function and leads to cognitive decline. Current research focuses on finding ways to reduce AB plaques.
Justice, Donovan, Joshi, Smita
core  

Nanoencapsulation of Withaferin-A for the Treatment of Neurological Disorder

, 2022
A better delivery mechanism is ensured by a superior formulation. This study is based on the fact that people believe in natural products more than chemical products.
Sonu Sharma, Dr. Viney Lather, Dr. Vikram Sharma
core  

PROTECTIVE EFFECT OF WITHAFERIN-A ON MICRONUCLEUS FREQUENCY AND DETOXICATION AGENTS DURING EXPERIMENTAL ORAL CARCINOGENESIS

, 2008
Our aim was to investigate the effect of Withaferin-A on bone marrow micronucleus frequency and buccal mucosa detoxication agents during 7, 12–dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis.
Panjamurthy, K., Manoharan, S., Nirmal, M. R., Alias, L. M., Suresh, K., Balakrishnan, S., Senthil, N.   +6 more
core  

Efficacy of Withania somnifera chemotypes NMITLI – 101R, 118R and Withaferin A against experimental visceral leishmaniasis

, 2014
The immunoprophylactic and therapeutic potentials of root extracts of Withania somnifera chemotypes (NMITLI-118, NMITLI-101) and pure withanolide–withaferin A was investigated against Leishmania donovani infection in hamsters.The naive animals, fed ...
A. Dube, S. Misra Bhattacharya, MANDAL, C, MISRA BHATTACHARYA, S, R. Gupta, TRIPATHI, C. D. P, GUPTA, R, KUSHAWAHA, P. K, Dube, A, C. Mandal, C. D. P. Tripathi, P. K. Kushawaha   +11 more
core   +1 more source