Results 101 to 110 of about 3,494 (215)

Integrative Machine Learning, Virtual Screening, and Molecular Modeling for BacA-Targeted Anti-Biofilm Drug Discovery Against Staphylococcal Infections

Crystals
The rise in antibiotic-resistant Staphylococcal infections necessitates innovative approaches to identify new therapeutic agents. This study investigates the application of machine learning models to identify potential phytochemical inhibitors against ...
Ahmad Almatroudi
doaj   +1 more source

Withanolide Compounds as Inhibitors of Fibrosis and Identification of Molecular Targets for Anti-Fibrotic Drug Development [PDF]

, 2012
Provided are methods for screening for drugs effective for treating fibrotic conditions. One screening method comprises exposing a cell to a test compound, monitoring the effect of the test compound on the amount or form of a cell molecule, comparing the
Mohan, Royce, Bargagna-Mohan, Paola
core   +1 more source

Withanolide glycosides from Physalis volubilis

Fitoterapia
The study of the acetone and methanol extracts of the stems, leaves, and flowers of Physalis volubilis led to obtain four withanolide glycosides (4, 6, 10, and 14). Compounds 1-3, 13, 15, and a sterol glycoside were also isolated. The structures were established by analysis of spectroscopic and spectrometric data, and by chemical transformations.
Ana-L, Pérez-Castorena, Tonantzin G, Anguheven L, M Azucena, Martínez R, Jesús, Morales-Jiménez, Emma, Maldonado, Mahinda, Martínez   +5 more
openaire   +2 more sources

Shoden promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels

Heliyon
Background: This randomized placebo-controlled study examined the effect of ashwagandha root and leaf extract 60 mg (AE60) and 120 mg (AE120) (35 % withanolide glycosides, Shoden) in physically healthy subjects with higher stress and anxiety.
Deo Nidhi Mishra, Manoj Kumar
doaj   +1 more source

Antitumor effect of withanolide D: a scoping review protocol

This scoping review aims to identify studies that have investigated the antitumor effects of withanolide D and map the main ...
Karuza Maria Aves Pereira, Sthefane Gomes Feitosa, Denis Francisco Gonçalves de Oliveira   +2 more
core   +1 more source

Effect of Withanolide A on oxidative stress markers.

, 2014
Administration of Withanolide A decreases the hypoxia induced elevated level of reactive oxygen species, lipid peroxidation and GSH in hippocampus. Data expressed as percentage change taking normoxic value as 100% and represents Mean ± SEM. ‘a’ denotes p≤
Pradeep Kumar Naik (436805), Jayanta Kumar Sahu (643672), Vishal Jain (14349), Govindasamy Ilavazhagan (414361), Iswar Baitharu (414359), Satya Narayan Deep (643670), Sabita Shroff (643671)   +6 more
core   +1 more source

Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, isoenzyme, polypeptide and withanolide profile diversity

, 2009
Withania somnifera is one of the most important medicinal plants of Ayurveda and finds extensive uses in Indian traditional herbal preparations. In this investigation, selected accessions of the plant were examined for diversity through RAPDs, isoenzymes,
Sangwan, Rajender S., Misra, Laxmi N., Sangwan, Neelam S., Chaurasiya, Narayan D., Tuli, Rakesh   +4 more
core   +1 more source

Data for: Profiling Withanolide A for Therapeutic Targets in Neurodegenerative Diseases

, 2019
This is the supporting information for the article by Crane et al, (2019) "Profiling Withanolide A for Therapeutic Targets in Neurodegenerative Diseases "
Erika Crane (7017518), Stephan Sieber (449608), Elma Mons (1763260), Angelo Vedani (2175378), Lydia Barth (7017524), Martin Smiesko (1637800), Wolfgang Heydenreuter (6184424), Karl Gademann (1233621), Jan Vormacka (7017521), Alex Odermatt (27423), Katharina Beck (5204546), Petra Strajhar (7017515), Markus Neuburger (1233615)   +12 more
core   +1 more source

Estimation of withanolide A in diverse genotypes of Ashwagandha Withania somnifera (L.) Dunal [PDF]

, 2019
212-217Withania somnifera (L.) Dunal (Fam. Solanaceae) commonly known as Ashwagandha has been used in traditional Indian medicine system from ancient times. Roots of the plant are being used in the preparation of many Ayurvedic medicines for treatment of
Joshi, Arunabh, Jain, Rohit, Jain, Devendra, Chauhan, Surya   +3 more
core  

Antiviral Activity of Withanolide A Against Different Infectivity Phases of Dengue Virus Serotype 2 in Vero Cell Line

Dengue fever is caused by the Aedes mosquito-borne dengue virus, which is a global threat with 400 million cases reported annually and 5–20% mortality rate. Currently, there is no effective treatment available for dengue fever.
Lee, Michelle Felicia *, Batumalaie, Kalaivani, Mahendran Sekar, Fuloria, Neeraj Kumar, Neeraj Kumar Fuloria, Poh, Chit Laa *, Nafees Ahemad, Shivkanya Fuloria, Subramaniyan, Vetriselvan, Chit, Laa Poh, Sekar, Mahendran, Ahemad, Nafees, Kalaivani Batumalaie, Wu, Yuan Seng *, Michelle felicia lee, Yuan, Seng Wu, Lujin Al Quwatli, Vetriselvan Subramaniyan, Al Quwatli, Lujin, Fuloria, Shivkanya, Sarke, Moklesur Rahman, Moklesur Rahman Sarke, Rhanye Mac Guad, Guad, Rhanye Mac   +23 more
core   +1 more source