Results 81 to 90 of about 3,494 (215)

Molecular docking studies of various bioactive molecules from Withania somnifera against bronchial asthma

Current Issues in Pharmacy and Medical Sciences
Asthma is a complex respiratory disorder characterized by chronic inflammation and hyperresponsiveness of the bronchial airways. Despite the availability of effective treatments and diagnostic methods, some patients remain symptomatic and exhibit a poor
Nafaa H. Ali, Khursheed A. Sheikh, Maaz Naqvi, Sana Rehman, Kavita Gulati, Arunabha Ray   +5 more
doaj   +1 more source

Ashwagandha Root Extract and Its Potential Modulation of CCN1‐Associated Pathways in Sensitive‐Skin Aging

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress‐induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1‐associated pathways. Aims To investigate whether ARE can mitigate sensitive‐skin aging by modulating CCN1 expression
Liying Kang, Yanhong Liu, Yuchen Xin, Lin Geng, Shaochun Cai, Jianfang Luo, Shaojie Gu, Shuangyan Wang, Zhiting Zhang, Yan Huang, Guixuan Zhou, Li Ye, Dongcui Li, Naisheng Jiang   +13 more
wiley   +1 more source

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source

A Novel Withanolide Glucoside from the Rhizomes of Dioscorea panthaica

, 2013
A novel withanolide type C-28-steroid saponin, named dioscolide glucoside, was isolated from the rhizomes of Dioscorea panthaica Prain et Buckill. The structure was elucidated as (20S,22R,24R,25S)-1-oxo-2 alpha,3 alpha;6 alpha,7 alpha-diepoxy-5 alpha,16 ...
Wang Xiaoling, Liang Jian, Shan Xiaoqing, Ding Lisheng, Peng Shulin   +4 more
core  

Evolution of withanolide biosynthesis in nightshades

Withanolides are a diverse class of defensive metabolites produced by multiple clades within the nightshade family (Solanaceae). To evaluate whether withanolide biosynthesis originated independently across these lineages, we investigated the evolutionary
Saleh Alseekh, Sofía Rojas Contreras, Santiago Perez, Eva Knoch, Rocío Deanna, Federico Roda, Stacey D. Smith, Alisdair Fernie   +7 more
core   +1 more source

Modulation of hippocampal endogenous glutathione level by Withanolide A reduces hypoxia induced neurodegeneration.

, 2014
Withanolide A effectively decreases the number of degenerating neurons caused by hypoxic exposure. However, depletion of glutathione using buthionine sulfoximine during hypoxic exposure increases the number degenerating cells in hippocampus.
Pradeep Kumar Naik (436805), Jayanta Kumar Sahu (643672), Vishal Jain (14349), Govindasamy Ilavazhagan (414361), Iswar Baitharu (414359), Satya Narayan Deep (643670), Sabita Shroff (643671)   +6 more
core   +1 more source

Efecto de la aplicación de elicitores sobre la producción de 4b-hidroxiwithanólido E, en raíces transformadas de Physalis peruviana L

Universitas Scientiarum, 2009
Effect of elicitor application on the production of 4-b-hydroxy withanolide E by hairy roots of Physalis peruviana. Objectives: Tostudy the metabolite 4-b-hydroxy withanolide E production by the in vitro culture of golden berry (Physalis peruviana L ...
Yineth Piñeros-Castro, Ángela Otálvaro-álvarez, Mario Velásquez-Lozano   +2 more
doaj  

Withanolide A mediated elevation of hippocampal glutathione during hypoxia is corticosterone dependent.

, 2014
Withanolide A administration during hypoxic exposure upregulates Nrf2 and GCLC expression in hippocampus. Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC ...
Pradeep Kumar Naik (436805), Jayanta Kumar Sahu (643672), Vishal Jain (14349), Govindasamy Ilavazhagan (414361), Iswar Baitharu (414359), Satya Narayan Deep (643670), Sabita Shroff (643671)   +6 more
core   +1 more source

Withanolide A mediated transcriptional regulation of Nrf2 and GCLC expression depend on corticosterone signaling in hippocampus.

, 2014
Withanolide A administration during hypoxic exposure upregulates Nrf2 and GCLC expression in hippocampus. Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC ...
Pradeep Kumar Naik (436805), Jayanta Kumar Sahu (643672), Vishal Jain (14349), Govindasamy Ilavazhagan (414361), Iswar Baitharu (414359), Satya Narayan Deep (643670), Sabita Shroff (643671)   +6 more
core   +1 more source

Atomic Force Microscopic (AFM) studies to visualize alteration in HSA molecule topology in presence of withanolide and withanoside derivatives at 10 μM resolution.

, 2018
(A) Only HSA (B) HSA+withanolide A (C) HSA+withanolide B (D) HSA+withanolide IV and (E) HSA+withanolide V.
Arijit Sarkar (5942156), Monika Kallubai (618436), Shreya Dubey (3820303), Rajagopal Subramanyam (297691)   +3 more
core   +1 more source