Results 91 to 100 of about 3,494 (215)

Modulatory effects of Withanolide A and β-Amyloid_1-42 on human neuronal cells.

, 2014
A. Dose-response of Withanolide A showing growth-stimulatory effects in terms of % viability. B. MTT assay showing the inhibition of cell viability by β-Amyloid1-42 and its reversal by Withanolide A at two concentrations on SK-N-MC cells. The values were
Thangavel Samikkannu (471645), Madhavan P. N. Nair (404586), Adriana Yndart (404585), Venkata Subba Rao Atluri (404582), Kesava Rao Venkata Kurapati (471644), Elena Kaftanovskaya (664371)   +5 more
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Withanolide Artifacts Formed in Methanol

, 2016
Methanol solutions of the main withanolides (6–8) naturally present in Physalis longifolia yielded five artificial withanolides (1–5), including three new compounds (1–3).
Robert J. Gallagher (1880416), Barbara N. Timmermann (1502962), Huaping Zhang (1828219), Cong-Mei Cao (228099)   +3 more
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Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis

, 2018
Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera, source of pharmaceutically important withanolides biosynthesizes withaferin-A in leaves and withanolide-A in roots.
Sumit Soni, Shiv S. Pandey, Sucheta Singh, Madhumita Srivastava, M. M. Gupta, Harshita Pandey, Tania Ray, Suchitra Banerjee, Alok Kalra, Alok Pandey, Karuna Shanker, C. S. Vivek Babu   +11 more
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Two New Withanolide Lactones from Flos Daturae

Molecules, 2011
Chemical investigation of the 50% ethanol eluate fraction from a macroporous resin of flowers of Datura metel L. collected in the Jiangsu Province of China resulted in the isolation of two new withanolides, baimantuoluoline G (1) and baimantuoluoside H ...
Yong-Gang Xia, Qiu-Hong Wang, Bing-You Yang, Hai-Xue Kuang   +3 more
doaj   +1 more source

Nanoparticles alter the withanolide biosynthesis and carbohydrate metabolism in Withania somnifera (Dunal)

, 2019
International audienceWithania somnifera is an important medicinal plant due to the presence of secondary metabolites. Nanoparticles (NPs) have elicitor activity for the enhancement of secondary metabolites biosynthesis in plants. W.
Dhawan, Sunita Singh, Singh, Dharmendra Pratap, Gupta, Pankhuri, Jain, Payal, Singh, Ruchi, Mishra, Tripti, Kumar, Anil, Shirke, Pramod Arvind   +7 more
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Molecular Modeling, NOESY NMR, and the Structure of Nicandrenone Isolated from (Solanaceae)

Natural Product Communications, 2009
The configuration and conformation of nicandrenone, isolated from Nicandra physalodes , are described using molecular modeling and NMR NOESY techniques.
Patrick F. Jonas, Geoffrey A. Cordell
doaj   +1 more source

Pubescenol, a new withanolide from Physalis pubescence

, 1985
The isolation from Physalis pubescence of a new withanolide (now named pubescenol) and physalin E and its acetate is reported. The structure of pubescenol was shown to be 2,3-dihydro-4α ,7α -dihydroxy-1-oxo-24α ,25α -epoxywithanolide on the basis of its ...
Sambi Reddy, K., Matsuura, Teruo, Ramachandra Row, L.   +2 more
core   +1 more source

Structure-based virtual screening methods for the identification of novel phytochemical inhibitors targeting furin protease for the management of COVID-19

Frontiers in Cellular and Infection Microbiology
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, is a highly contagious respiratory disease with widespread societal impact.
Prashant Kumar Tiwari, Mandeep Chouhan, Richa Mishra, Saurabh Gupta, Anis Ahmad Chaudhary, Mohammed Al-Zharani, Ashraf Ahmed Qurtam, Fahd A. Nasr, Niraj Kumar Jha, Niraj Kumar Jha, Niraj Kumar Jha, Kumud Pant, Mukesh Kumar, Sanjay Kumar   +13 more
doaj   +1 more source

Synergistic activity of nootropic herbs as potent therapeutics for Alzheimer's disease: A cheminformatics, pharmacokinetics, and system pharmacology approach

Journal of Alzheimer's Disease Reports
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which subdues over 55 million people and finding a cure, still remains disenchanting.
Reiya Bosco Don Bosco, Johnson Retnaraj Samuel Selvan Christyraj, Beryl Vedha Yesudhason   +2 more
doaj   +1 more source

Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin - Fig 1

, 2018
The structure of withanolide A (C28H38O6-470.6Da), withanolide B (C28H38O5-454.6Da), withanoside IV (C40H62O15-782.9Da) and withanoside V (C40H62O14-766.9Da).
Arijit Sarkar (5942156), Monika Kallubai (618436), Shreya Dubey (3820303), Rajagopal Subramanyam (297691)   +3 more
core   +1 more source