Results 71 to 80 of about 3,494 (215)

A New Rearranged Non-Aromatic Salpichrolide from Salpichroa Origanifolia

Molecules, 2000
From the aerial parts of Salpichroa origanifolia a new withanolide in which the C-13 angular methyl has migrated to C-17, was isolated and characterized by spectroscopic methods.
M. C. Tettamanzi, J. R. De La Fuente, A. S. Veleiro, G. Burton   +3 more
doaj   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Amelioration of bromobenzene hepatotoxicity by Withania somnifera pretreatment: Role of mitochondrial oxidative stress

Toxicology Reports, 2014
The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria.
Mahima Vedi, Mahaboobkhan Rasool, Evan Prince Sabina   +2 more
doaj   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha ( Withania somnifera )

Phytotherapy Research, Volume 40, Issue 8, Page 5030-5047, August 2026.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source

Safety of 8‐Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi‐Center, Double‐Blinded, Placebo‐Controlled Study

Phytotherapy Research, Volume 40, Issue 8, Page 5005-5015, August 2026.
ABSTRACT Ashwagandha ( Withania somnifera ) has been recognized for enhancing physical strength, mental well‐being, and overall vitality. Despite its long‐standing use across generations, some clinical reports have noted occasional adverse events. This study compared the safety and tolerability of Ashwagandha Root Extract (ARE) in healthy adults.
Ketan Pakhale, Jaising Salve, John Ademola, Jose Parraca, Deepak Langade   +4 more
wiley   +1 more source

Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against α-glucosidase and α-amylase

, 2023
Diabetes mellitus (DM) is a global chronic disease characterized by hyperglycemia and insulin resistance. The unsavory severe gastrointestinal side-effects of synthetic drugs to regulate hyperglycemia have warranted the search for alternative treatments ...
Mohd Hayrie, Mohd Hatta, Oyewusi, Habeebat Adekilekun, Safi, Sher Zaman, Kalaivani, Batumalaie, Wu, Yuan Seng *, Roswanira, Abdul Wahab   +5 more
core   +1 more source

Synthesis, Characterization and Anti-Cancer Therapeutic Potential of Withanolide-A with 20nm sAuNPs Conjugates Against SKBR3 Breast Cancer Cell Line

International Journal of Nanomedicine, 2020
Qudsia Tabassam,1 Tahir Mehmood,1,2 Abdul Rauf Raza,1 Azmat Ullah,3 Farhan Saeed,4 Faqir Muhammad Anjum5 1Department of Chemistry, University of Sargodha, Sargodha, Pakistan; 2Institute of Biochemistry and Biotechnology, University of Veterinary and ...
Tabassam Q, Mehmood T, Raza AR, Ullah A, Saeed F, Anjum FM   +5 more
doaj  

Laser‐Enabled Biotechnology Platforms for Climate‐Resilient Crop Production: Mechanistic Insights and Future Prospects

Food and Energy Security, Volume 15, Issue 4, July/August 2026.
ABSTRACT Climate change poses a major threat to global food security through extreme weather events, expanding pathogen ranges, and increased agrochemical dependency. This review highlights the emerging role of laser biotechnology as a sustainable and precise strategy to enhance crop resilience and productivity under climate stress.
Temoor Ahmed, Yumeng Lei, Muhammad Noman, Zhitao Li, Gabrijel Ondrasek, Muhammad Shafiq Shahid, Branko Petrinec, Xingjiang Qi, Bin Li, Yetong Qi   +9 more
wiley   +1 more source

Transmission Electron Microscopic (TEM) studies to visualize alteration in HSA molecule topology in presence of withanolide and withanoside derivatives at 200 nM resolution.

, 2018
(A) Only HSA (B) HSA+withanolide A, (C) HSA+withanolide B, (D) HSA+withanolide IV and (E) HSA+withanolide V.
Arijit Sarkar (5942156), Monika Kallubai (618436), Shreya Dubey (3820303), Rajagopal Subramanyam (297691)   +3 more
core   +1 more source

Orizabolide, a New Withanolide from Physalis orizabae

, 2017
A new withanolide, orizabolide (<strong>1</strong>), together with the known flavonoid rutin (<strong>2</strong>) were isolated from the aerial parts of <em>Physalis orizabae</em>.
Mahinda Martínez, Emma Maldonado, Rodrigo Gutiérrez, Ana L. Pérez-Castorena   +3 more
core   +2 more sources