Results 61 to 70 of about 3,494 (215)

Burmannic Acid With Normal Cell Safety Exhibits ROS‐Mediated X‐Ray‐Sensitizing Effects on Oral Cancer Cells

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Burmannic acid (BURA) boosts radiosensitivity in oral cancer: combined with x‐rays, it suppresses tumor growth while sparing normal cells by increasing reactive oxygen species (ROS, MitoSOX), causing G2/M arrest, sub‐G1 accumulation, mitochondrial dysfunction, DNA damage, and apoptosis; these effects are reversed by N‐acetylcysteine. Therefore, BURA is
Kun‐Han Yang, Chung‐Yi Chen, Ching‐Yu Yen, Hsin‐I Lu, Jen‐Yang Tang, Tsu‐Ming Chien, Fang‐Rong Chang, Jiiang‐Huei Jeng, Ming‐Yii Huang, Hsueh‐Wei Chang   +9 more
wiley   +1 more source

Withanolide A mediated restoration of endogenous glutathione level reverses hypoxia induced neuronal apoptosis in hippocampus.

, 2014
Administration of withanolide A prior to and during hypoxic exposure decreases number of apoptotic cells in CA3 region of hippocampus while glutathione depletion using buthionine sulfoximine elevates hypoxic neuronal apoptosis.
Pradeep Kumar Naik (436805), Jayanta Kumar Sahu (643672), Vishal Jain (14349), Govindasamy Ilavazhagan (414361), Iswar Baitharu (414359), Satya Narayan Deep (643670), Sabita Shroff (643671)   +6 more
core   +1 more source

Physapubescin B From Physalis: A Food‐Derived Withanolide for Cancer Chemoprevention and Nutraceutical Development

eFood, Volume 7, Issue 4, August 2026.
Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch, Katarzyna Stępnik, Anna Wawruszak, Estera Okoń, Agata Jarząb, Katarzyna Gaweł‐Bęben, Magdalena Michalak‐Tomczyk, Jacek Jachuła, Magdalena Zdziebło, Paweł Helon, Javad Sharifi‐Rad, Daniela Calina   +11 more
wiley   +1 more source

Biotechnological Intervention and Withanolide Production in Withania coagulans

Agronomy, 2023
Withania coagulans (Stocks) Dunal is used in traditional medicine to treat diseases and has numerous pharmacological properties due to its biological compounds.
Zishan Ahmad, Arjumend Shaheen, Adla Wasi, Shams ur Rehman, Sabaha Tahseen, Muthusamy Ramakrishnan, Anamica Upadhyay, Irfan Bashir Ganie, Anwar Shahzad, Yulong Ding   +9 more
doaj   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, Volume 40, Issue 8, Page 4792-4801, August 2026.
ABSTRACT The preclinical evidence for the safety of ashwagandha ( Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports. Most studies and reviews conclude
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

A decade of molecular understanding of withanolide biosynthesis and in vitro studies in Withania somnifera (L.) Dunal: Prospects and perspectives for pathway engineering

Frontiers in Plant Science, 2015
Withania somnifera, a multipurpose medicinal plant is a rich reservoir of pharmaceutically active triterpenoids that are steroidal lactones known as withanolides.
Niha eDhar, Sumeer eRazdan, Satiander eRana, Wajid Waheed Bhat, Ram eVishwakarma, Surrinder K. Lattoo   +5 more
doaj   +1 more source

Safety of 12‐Months Administration of Ashwagandha ( Withania somnifera ) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, Volume 40, Issue 8, Page 4802-4812, August 2026.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

Sonication, Vacuum Infiltration and Thiol Compounds Enhance the Agrobacterium-Mediated Transformation Frequency of Withania somnifera (L.) Dunal. [PDF]

PLoS ONE, 2015
In the present study, we have established a stable transformation protocol via Agrobacterium tumafacines for the pharmaceutically important Withania somnifera.
Ganeshan Sivanandhan, Gnajothi Kapil Dev, Jeevaraj Theboral, Natesan Selvaraj, Andy Ganapathi, Markandan Manickavasagam   +5 more
doaj   +1 more source

Ashwagandha: Is It Safe? Part 1: A Regulatory Review

Phytotherapy Research, Volume 40, Issue 8, Page 4845-4857, August 2026.
ABSTRACT Over the last decade, ashwagandha ( Withania somnifera (L.) Dunal, AS) has been brought under increasing scrutiny by EU regulators regarding its safety for the use in food supplements, culminating in a recent recommendation for an Article 8 procedure according to Regulation (EC) No. 1925/2006 in the European Union (EU).
T. Brendler, R. Al‐Mondhiry, L. Lang, R. Marles, M. Tallon, A. Raghu   +5 more
wiley   +1 more source

WsCAS transcript expression analysis and withanolide accumulation in Withania silencing and overexpressing lines.

, 2016
(A) RealTime PCR analysis of WsCAS silenced lines. (B) Withanolide content in silenced lines. (C) Real-Time PCR analysis of WsCAS overexpressing lines. (D) Withanolide content in WsCAS overexpressing lines.
Asha (2504188), Jyoti Singh Jadaun (2504191), Smrati Mishra (2504185), Shilpi Bansal (2504179), Neelam S. Sangwan (534505), Bhawana Mishra (2504182), Rajender Singh Sangwan (411130)   +6 more
core   +1 more source