Results 51 to 60 of about 3,494 (215)

Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production

Biomolecules, 2021
24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
doaj   +1 more source

Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. [PDF]

PLoS ONE, 2014
The present study investigated the biosynthesis of major and minor withanolides of Withania somnifera in cell suspension culture using shake-flask culture and bioreactor by exploiting elicitation and precursor feeding strategies.
Ganeshan Sivanandhan, Natesan Selvaraj, Andy Ganapathi, Markandan Manickavasagam   +3 more
doaj   +1 more source

Phytochemical Composition and Antibacterial Activity of Medicinal Plants Against Bacterial Pathogens Isolated From Livestock Wound Infections

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The graphical abstract visually summarizes the study's key findings: it lists the major bacterial pathogens isolated from livestock wounds (such as S. aureus and E. coli) and the medicinal plants tested (Withania somnifera, Achyranthes aspera. It highlights the phytochemicals (alkaloids, flavonoids, etc.) present in the plant extracts and shows that ...
Safia Arbab, Hanif Ullah, Mian Sayed Khan, Khalaf F. Alsharif, Fuad M. Alzahrani, Khalid J. Alzahrani, Zhongyi Zeng, Li Ka   +7 more
wiley   +1 more source

Pubescenol, a withanolide from Physalis pubescence

, 1984
A new withanolide, named pubescenol, and also physalin E and physalin E acetate have been isolated from Physalis pubescence. The structure of pubescenol is assigned as 4α,7α-dihydroxy-l-oxo-24α,25α-epoxy-2,3 ...
Dhaveji, K., Sambi Reddy, K., Matsuura, Teruo, Ramachandra Row, L.   +3 more
core   +1 more source

Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells. [PDF]

PLoS ONE, 2016
The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem for
Chandan Seth, Christophe Mas, Arwen Conod, Jens Mueller, Karsten Siems, Monika Kuciak, Isabel Borges, Ariel Ruiz I Altaba   +7 more
doaj   +1 more source

Pharmacological Effects of withanolides [PDF]

Open Access Journal of Complementary & Alternative Medicine, 2019
Withania somnifera (L.) Dunal (Family, Solanaceae) commonly known as Ashwgandha or winter cherry is one of the top medicinal herbs used in Ayurveda-the holistic system of Indian medicine.
openaire   +1 more source

Chlorinated withanolides from Withania somnifera [PDF]

Phytochemistry Letters, 2011
A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were ...
Tong, Xiaoqin, Zhang, Huaping, Timmermann, Barbara N.   +2 more
openaire   +3 more sources

Receptor‐Targeted Niosomal Nanocarriers: Advances, Challenges, and Opportunities in Natural Compound Delivery for Cancer Therapy

Nano Select, Volume 7, Issue 10, October 2026.
Surface‐modified niosomes are introduced as multifunctional nanoparticles for precision tumor treatment that combine hydrophilic and lipophilic drug encapsulation with ligand‐based targeting via antibodies, peptides, transferrin, and folic acid. This modification leads to increased tumor selectivity, facilitates cell entry, and enables enhanced ...
Narges Sahraei, Aryan M. Faraj, Faezeh Molaei, Abolfazl Barzegar   +3 more
wiley   +1 more source

Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin - Fig 7

, 2018
Molecular docking studies between HSA and withanolide A, withanolide B, withanoside IV and withanoside V showed that the minimum binding energy conformer is very close to the experimentally determined values.
Arijit Sarkar (5942156), Monika Kallubai (618436), Shreya Dubey (3820303), Rajagopal Subramanyam (297691)   +3 more
core   +1 more source

Screening of phytochemicals from Withania somnifera, Rauwolfia serpentina, Curcuma longa, and Camellia sinensis for potential maltase-glucoamylase (MGAM) inhibition using molecular docking, molecular dynamics simulation, and ADMET analysis

In Silico Research in Biomedicine
Postprandial hyperglycemia is a major concern in type 2 diabetes, and inhibition of intestinal α-glucosidases [maltase-glucoamylase (MGAM)] is an established approach for controlling postprandial glucose excursions.
Ashim Chandra Roy, Ilora Ghosh
doaj   +1 more source