Results 11 to 20 of about 3,494 (215)

Enhancing Withanolide Production in the Withania Species: Advances in In Vitro Culture and Synthetic Biology Approaches

Plants
Withanolides are naturally occurring steroidal lactones found in certain species of the Withania genus, especially Withania somnifera (commonly known as Ashwagandha).
Zishan Ahmad, Shareen, Irfan Bashir Ganie, Fatima Firdaus, Muthusamy Ramakrishnan, Anwar Shahzad, Yulong Ding   +6 more
doaj   +2 more sources

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer

Drug Design, Development and Therapy, 2017
Dharmendra K Yadav,1 Surendra Kumar,2 Saloni,1 Harpreet Singh,3 Mi-hyun Kim,1 Praveen Sharma,4 Sanjeev Misra,4 Feroz Khan5 1Department of Pharmacy, College of Pharmacy, Gachon University, Yeonsu-gu, Incheon, Republic of Korea; 2Faculty of Pharmacy ...
Yadav DK, Kumar S, Saloni, Singh H, Kim M, Sharma P, Misra S, Khan F   +7 more
doaj   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications. [PDF]

Phytother Res
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Yukta R, Gupta S, Kaur G, Mondal PS, Das M, Ranade A, Srivastava AK, Kumar S, Barthwal MK, Dikshit M.   +9 more
europepmc   +2 more sources

The Total Synthesis of Analogues of Withanolide F [PDF]

, 2014
The total synthesis of analogues of withanolide F I, a highly oxygenated C-28 steroidal lactone natural product isolated from the leaves of the plant Withania adpressa is discussed herein. Chapter 1 describes the classification of the withanolides, their
Manicassamy, Laura
core   +6 more sources

Deciphering Antidiabetic, Anti-Inflammatory, and Anti-Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation. [PDF]

Chem Biodivers
In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Mulelu L, Manjia JN, Olofinsan KA, Xulu L, Matsabisa MG.   +4 more
europepmc   +2 more sources

Plant Part–Specific Differences in Ashwagandha (Withania somnifera): A Comparative Evaluation of Root and Leaf Evidence for Safety and Regulation [PDF]

Food Sci Nutr
This review contrasts the root and leaf of Withania somnifera (ashwagandha) across phytochemistry, clinical evidence, and regulatory context. Root preparations are dominated by withanolide A, D, and glyco‐withanolides, with multiple randomized controlled trials supporting reductions in stress, anxiety, and insomnia alongside a favorable safety profile.
Dutta A, Gupta J.
europepmc   +2 more sources

Withasomniferol D, a New Anti-Adipogenic Withanolide from the Roots of Ashwagandha (Withania somnifera)

Pharmaceuticals, 2021
Withania somnifera (Solanaceae), well-known as ‘Indian ginseng’ or ‘Ashwagandha’, is a medicinal plant that is used in Ayurvedic practice to promote good health and longevity.
Bum Soo Lee, Min Jeong Yoo, Heesun Kang, Seoung Rak Lee, Sil Kim, Jae Sik Yu, Jin-Chul Kim, Tae Su Jang, Changhyun Pang, Ki Hyun Kim   +9 more
doaj   +1 more source

Molecular characterization of three CYP450 genes reveals their role in withanolides formation and defense in Withania somnifera, the Indian Ginseng

Scientific Reports, 2022
The medicinal properties of Ashwagandha (Withania somnifera) are attributed to triterpenoid steroidal lactones, withanolides, which are proposed to be derived from phytosterol pathway, through the action of cytochrome P450 (CYP450) enzymes.
H. B. Shilpashree, S. J. Sudharshan, Ajit K. Shasany, Dinesh A. Nagegowda   +3 more
doaj   +1 more source

Low Dose Combined Treatment with Ultraviolet-C and Withaferin a Enhances Selective Killing of Oral Cancer Cells

Antioxidants, 2020
Withaferin A (WFA), a Withania somnifera-derived triterpenoid, is an anticancer natural product. The anticancer effect of nonionizing radiation such as ultraviolet-C (UVC) as well as the combined treatment of UVC and WFA is rarely investigated.
Sheng-Yao Peng, Yen-Yun Wang, Ting-Hsun Lan, Li-Ching Lin, Shyng-Shiou F. Yuan, Jen-Yang Tang, Hsueh-Wei Chang   +6 more
doaj   +1 more source

Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions

Journal of Nutrition and Metabolism, 2023
Background. Ashwagandha extracts play a significant role in traditional Indian medicine to help treat a wide range of disorders from amnesia, erectile dysfunction, neurodegenerative and cardiovascular diseases, cancer, stress, anxiety, and many more ...
Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Ritam Chatterjee   +4 more
doaj   +1 more source