Results 121 to 130 of about 1,755 (175)

Natural withanolides, an update

Natural Product Reports, 2022
This review summarizes the research progress on the structural classification, biological activities and mechanisms, metabolism and pharmacokinetic investigations, biosynthesis, and synthesis and structural modifications of the withanolides.
Gui-yang Xia, Shi-jie Cao, Li-xia Chen, Feng Qiu   +3 more
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Withanolides from Discopodium penninervium

Fitoterapia, 2023
Discopodium penninervium is a medicinal plant endemic to Ethiopia. Its twigs extract led to the isolation of three new withanolides, discopodinolides A - C, and four known analogues. The structures of the compounds were elucidated using NMR, HRMS data analyses, and literature data.
Kibrom Gebreheiwot, Bedane, Mekonnen Abebayehu, Desta, Peter, Spiteller   +2 more
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Natural withanolides: an overview

Natural Product Reports, 2011
Withanolides are a group of naturally occurring C28 steroids built on an ergostane skeleton functionalized at carbons 1, 22 and 26, commonly known as the withanolide skeleton. Over the period of August 1996 to March 2010, 360 new naturally occurring withanolides were isolated and identified.
Li-Xia, Chen, Hao, He, Feng, Qiu
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Trypanocidal Withanolides and Withanolide Glycosides from Dunalia brachyacantha

Journal of Natural Products, 2001
Two new withanolide glycosides, (20R,22R)-O-(3)-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl-1 alpha,12 beta-diacetoxy-20-hydroxywitha-5,24-dienolide (3) and (20R,22R)-O-(3)-beta-D-xylopyranosyl(1-->3)-[beta-D-xylopyranosyl(1-->4)]-beta-D-glucopyranosyl-1 alpha-acetoxy-12 beta,20-dihydroxywitha-5,24-dienolide (4), were isolated from the leaves ...
J A, Bravo B, M, Sauvain, A, Gimenez T, E, Balanza, L, Serani, O, Laprévote, G, Massiot, C, Lavaud   +7 more
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Withanolide C, A chlorinated withanolide from Withania somnifera

Phytochemistry, 1992
Abstract The structure of a new chlorinated withanolide isolated from Withania somnifera chemotype III has been elucidated as 5α-chloro,6β,14α,17β,2Oα F -tetrahydroxy-l-oxo-22R-witha-2,24-dienolide by 1 H and 13 CNMR and chemical ionization mass spectroscopy methods.
Roberto Bessalle, David Lavie
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Natural Bioactive New Withanolides

Mini-Reviews in Medicinal Chemistry, 2020
Withanolides are a group of highly oxygenated steroids derived from a C28 ergostane skeleton, and have attracted significant scientific interest due to their complex structural features and multiple bioactivities. More than 170 new natural withanolides were isolated and identified in the last 5 years.
Qian-Qian, Xu, Kui-Wu, Wang
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Withanolide Y, a withanolide from a hybrid of Withania somnifera

Phytochemistry, 1987
Abstract The structure of a withanolide isolated from the hybrid of Withania somnifera chemotype III (Israel) by Indian I (Delhi) has been elucidated as (20R,22R)-5α,6α-epoxy-7α-17α,20-trihydroxy-1-oxo-witha-2,24-dienolide by X-ray single crystal analysis.
Roberto Bessalle, David Lavie, Felix Frolow   +2 more
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Withanolide Z, a New Chlorinated Withanolide fromWithania somnifera

Planta Medica, 2008
Reverse-phase preparative HPLC analysis of the n-butanol fraction of the methanolic extract of Withania somnifera Dunal (leaves) afforded a novel chlorinated withanolide, namely withanolide Z (1), along with four known withanolides, withanolide B (2), withanolide A (3), 27-hydroxywithanolide B (4) and withaferin A (5).
Swapan, Pramanick, Amit, Roy, Shekher, Ghosh, Hemanta K, Majumder, Sibabrata, Mukhopadhyay   +4 more
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Withanolides from Jaborosa kurtzii

Journal of Natural Products, 2007
Two new withanolides were isolated and characterized from the aerial parts of Jaborosa kurtzii, namely, jaborosalactone 43 (1), with a spiranoid delta-lactone at C-22, and jaborosalactone 44 (2), a 12-oxowithanolide, which may function as a biosynthetic precursor to 1.
Natalia S, Ramacciotti, Viviana E, Nicotra   +1 more
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Withanolide Artifacts Formed in Methanol

Journal of Natural Products, 2013
Methanol solutions of the main withanolides (6-8) naturally present in Physalis longifolia yielded five artificial withanolides (1-5), including three new compounds (1-3). Withanolides 1 and 2 were identified as intramolecular Michael addition derivatives, while withanolides 3-5 were the result of intermolecular Michael addition.
Cong-Mei, Cao, Huaping, Zhang, Robert J, Gallagher, Barbara N, Timmermann   +3 more
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