Results 241 to 250 of about 459,861 (330)

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing. [PDF]

Bone Res
Huang M, Balu AR, Molitoris KH, Bareja A, Baht GS.   +4 more
europepmc   +1 more source

Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells

, 2019
Wenbin Liang, Pengcheng Han, Elizabeth H. Kim, Jordan Mak, Rui Zhang, Angelo G. Torrente, Joshua I. Goldhaber, Eduardo Marbán, Hee Cheol Cho   +8 more
openalex   +2 more sources

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

LOXL2⁺ cancer-associated fibroblasts shape WNT signaling to drive chemoresistance and poor outcomes in colorectal cancer: Insights from multi-omics and epidemiological analyses. [PDF]

Neoplasia
Xu C, Li T, Zhang L, Zhang Q, Cai S, Fu Q, Zhang S.   +6 more
europepmc   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Epithelial WNT secretion drives niche escape of developing gastric cancer. [PDF]

Mol Cancer
Lee J, Kim S, Oh Y, Jahn SR, Kim J, Kim Y, Schmäche T, Kim SM, Teriyapirom I, Groß T, Kwon O, Kim J, Kim S, Ada AM, Català-Bordes A, Cho Y, Kim J, Andersson-Rolf A, Merker SR, Lim JY, Park JY, Klompstra TM, Yoon KJ, Lim DS, Lee HS, Kim JK, Choi E, Goldenring JR, Cheong JH, Kim H, Stange DE, Lee H, Koo BK, Lee JH.   +33 more
europepmc   +1 more source

Wnt wonderland [PDF]

Nature Reviews Molecular Cell Biology, 2001
openaire   +1 more source

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

Advanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova, Hannah Kronabitter, Mar Cervera‐Negueruela, Eylul Ceylan, Laura Benito‐Zarza, Rubén López‐Sandoval, Irineja Cubela, J. Gray Camp, Jose L. Garcia‐Cordero   +8 more
wiley   +1 more source

Deletion of <i>Rspo1</i> or <i>Rspo3</i> in the mesenchyme does not affect Wolffian duct maintenance or morphogenesis. [PDF]

MicroPubl Biol
Jia S, Wilbourne J, Fogarty A, Bai W, Zhao F.   +4 more
europepmc   +1 more source