Results 61 to 70 of about 315,126 (245)
Evolution of the Wnt Pathways [PDF]
, 2008 Wnt proteins mediate the transduction of at least three major signaling pathways that play central roles in many early and late developmental decisions. They control diverse cellular behaviors, such as cell fate decisions, proliferation, and migration, and are involved in many important embryological events, including axis specification, gastrulation ...
Croce, Jenifer, Mcclay, David
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Shiyan dongwu yu bijiao yixue, 2021 ObjectiveTo explore whether CD137-CD137L signaling can promote cardio-cerebral angiogenesis in atherosclerotic plaques via endothelium-mesenchymal transition (End-MT).MethodsMouse brain-derived endothelial cells (Bend.3) and aortas from male mice were ...
WENG Jiayi +3 more
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Wnt signaling: a common theme in animal development.
Genes & Development, 1997 Wnt proteins are now recognized as one of the major families of developmentally important signaling molecules, with mutations in Wnt genes displaying remarkable phenotypes in the mouse, Caenorhabditis elegans, and Drosophila.
K. Cadigan, R. Nusse
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Adipogenesis and WNT signalling [PDF]
Trends in Endocrinology & Metabolism, 2009 An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated.
Christodoulides, C +3 more
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Wnt Signaling Pathway and Chronic Myelogenous Leukemia
Zhongliu Fangzhi Yanjiu, 2019 As a type of cancer that starts in certain blood-forming cells of the bone marrow, chronic myeloid leukemia (CML) is caused by the formation of an abnormal gene called BCR-ABL1.
HOU Yan +6 more
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NORRIN plays a context-dependent role in glioblastoma stem cells
Molecular & Cellular Oncology, 2020 We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite ...
Ahmed El-Sehemy, Valerie A. Wallace
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Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled [PDF]
Open Biology, 2015 Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events in post-mitotic cells.
Thomas Mund +5 more
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Exosomes go with the Wnt [PDF]
Cellular Logistics, 2012 Exosomes, small secreted microvesicles, are implicated in intercellular communication in diverse cell types, transporting protein, lipid and nucleic acid cargo that impact the physiology of recipient cells. Besides the signaling function of exosomes they also serve as a mechanism to dispose obsolete cellular material.1 Particularly exciting is the ...
Koles, Kate, Budnik, Vivian
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Overcoming resistance to immunotherapy by teaching old drugs new tricks
Molecular & Cellular Oncology, 2020 Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments.
John M. Perry, Linheng Li
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Diseases of Wnt signaling [PDF]
Reviews in Endocrine and Metabolic Disorders, 2006 The Wnt signaling pathways play fundamental roles in the differentiation, proliferation, death and function of many cells and as a result are involved in critical developmental, growth and homeostatic processes in animals. There are four currently known pathways of Wnt signaling; the so-called canonical or Wnt/beta-catenin pathway, the Wnt/Ca(+2 ...
Mark L. Johnson, Nalini M. Rajamannan
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