Results 81 to 90 of about 315,126 (245)
Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights
Frontiers in Immunology, 2019 Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds to receptors belonging to the Frizzled family or the ROR1/ROR2 and RYK ...
Sonal A Patel +3 more
semanticscholar +1 more source
Updating the Wnt pathways [PDF]
Bioscience Reports, 2014 In the three decades since the discovery of the Wnt1 proto-oncogene in virus-induced mouse mammary tumours, our understanding of the signalling pathways that are regulated by the Wnt proteins has progressively expanded. Wnts are involved in an complex signalling network that governs multiple biological processes and cross-talk with multiple additional ...
Yu, J, Virshup, D.M
openaire +3 more sources
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease
Molecular Brain, 2019 Alzheimer’s disease (AD) is an aging-related neurological disorder characterized by synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction pathway that regulates numerous cellular processes including cell survival.
Lin Jia, J. Piña-Crespo, Yonghe Li
semanticscholar +1 more source
eLife, 2018 Development of specialized cells and structures in the heart is regulated by spatially -restricted molecular pathways. Disruptions in these pathways can cause severe congenital cardiac malformations or functional defects.
Silja Barbara Burkhard, Jeroen Bakkers
doaj +1 more source
Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology.
Annual Review of Pathology, 2018 The liver is an organ that performs a multitude of functions, and its health is pertinent and indispensable to survival. Thus, the cellular and molecular machinery driving hepatic functions is of utmost relevance.
Jacquelyn O. Russell, S. Monga
semanticscholar +1 more source
MicroRNA-361-3p Inhibit the Progression of Lymphoma by the Wnt/β-Catenin Signaling Pathway
Cancer Management and Research, 2020 Hui Zhou,1 Huifeng Tang,1 Ning Li,1 Hang Chen,1 Xiaohui Chen,1 Lei Gu,1 Liang Zhang,1 Guoyan Tian,1 Diehong Tao2 1Department of Hematology and Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, People’s Republic of ...
Zhou H +8 more
doaj
Turkish Journal of Hematology, 2015 OBJECTIVE: Lymphoid enhancer-binding factor-1 (LEF-1) is a key transcription factor of wingless-type (Wnt) signaling in various tumors and it is associated with a number of malignant diseases such as leukemia.
Rabab M. Aly, Ansaf B. Yousef
doaj +1 more source
Cancer Management and Research, 2020 Ting Zhan, 1,* Qingxi Zhu, 1,* Zheng Han, 1 Jie Tan, 1 Meng Liu, 1 Weijie Liu, 1 Wei Chen, 1 Xiaoli Chen, 1 Xueting Chen, 2 Junsheng Deng, 2 Xia Tian, 1 Xiaodong Huang 1 1Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan ...
Zhan T +11 more
doaj
Wnt Signaling and Drug Resistance in Cancer
Molecular Pharmacology, 2019 Wnts are secreted proteins that bind to cell surface receptors to activate downstream signaling cascades. Normal Wnt signaling plays key roles in embryonic development and adult tissue homeostasis.
Zheng Zhong, D. Virshup
semanticscholar +1 more source