Results 231 to 240 of about 5,118,873 (324)

Fzd2 orchestrates canonical and non-canonical Wnt signaling to regulate lung development and fibrosis. [PDF]

Cell Commun Signal
Zhou J, Lou X, Wei Z, Mao X, Zhang J, Jin X, Li B, Zheng C, Siwu X, Yang Y, Zhang Y, Chen W, Jiang M.   +12 more
europepmc   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids. [PDF]

Front Mol Biosci
Gupta A, Mehrotra A, Sood A, Sharma B, Yadav V, Kaur G, Sak K, Satapathy SR, Tuli HS.   +8 more
europepmc   +1 more source

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

Advanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova, Hannah Kronabitter, Mar Cervera‐Negueruela, Eylul Ceylan, Laura Benito‐Zarza, Rubén López‐Sandoval, Irineja Cubela, J. Gray Camp, Jose L. Garcia‐Cordero   +8 more
wiley   +1 more source

Smurf1 promotes gastric cancer progression by regulating Axin2-dependent Wnt signaling pathway. [PDF]

Sci Rep
Yu J, Jing J, Feng Z, Chen Z, Ji B, Hong J, Guo J, Tang N, Gu S.   +8 more
europepmc   +1 more source

Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma [PDF]

, 2017
Das, Sunit, Dhand, Karan, Guan, Jennifer, Gunter, Simon, Kim, Albert, Li, Chris, Morshead, Cindi, Ng, Sheena, Nusrat, Labeeba, Wu, Megan   +9 more
core   +3 more sources

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Correction: MEIS1 knockdown upregulates WNT signaling pathway genes in esophageal squamous cell carcinoma. [PDF]

BMC Med Genomics
Hosseini N, Forghanifard MM.
europepmc   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

NR1I3 modulates Wnt signaling to promote anterior-posterior axis patterning. [PDF]

BMC Biol
Sun Y, Ding N, Li S, Zhang Y, Qin Y, Hao Z, Zhang S, Tian Q.   +7 more
europepmc   +1 more source