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Wnt signaling pathway in development and cancer.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2018Wnt signaling pathway is one of the most important signaling pathways. The complexity of Wnt signals and their functional role is crucial in development and growth. It is the most active during embryogenesis facilitating new organism formation by cell differentiation, polarization and migration.
B, Taciak +4 more
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Roles of Axin in the Wnt Signalling Pathway
Cellular Signalling, 1999The Wnt signalling pathway is conserved in various species from worms to mammals, and plays important roles in development, cellular proliferation, and differentiation. The molecular mechanisms by which the Wnt signal regulates cellular functions are becoming increasingly well understood.
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The Wnt/Frizzled GPCR signaling pathway
Biochemistry (Moscow), 2010G protein-coupled receptors (GPCRs) represent the biggest transmembrane receptor family. The Frizzled group of GPCRs is evolutionarily conserved and serves to transduce signals from the Wnt-type lipoglycoprotein growth factors. The Wnt/Frizzled signaling cascades are repeatedly used during animal development and are mostly silent in the adult. Improper
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The Wnt Signaling Pathway in Retinal Degenerations
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2005The retina is a complex tissue composed of multiple interconnected cell layers, highly specialized for transforming light and color into electrical signals perceived by the brain. Damage or death of the primary light-sensing cells, the photoreceptors, results in devastating effects on vision.
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Wnt signaling: Sox Enters the Wnt Pathway
Science's STKE, 1999The Wnt signaling pathway regulates numerous cellular responses including those that govern axis formation and dorsal-ventral patterning in the developing Xenopus laevis embryo. Upon binding to its receptor Frizzled, a signaling cascade is triggered that results in β-catenin-dependent transcription of Wnt target ...
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The Wnt Signal Transduction Pathway
2000Wnt signaling plays a central role in the development of many phylogenetically diverse organisms including Drosophila, Caenorhabditis elegans, Xenopus, and higher vertebrates. In addition, genetic alterations of components in the pathway are associated with tumorigenesis in mice and humans, particularly melanomas and carcinomas of the breast and colon.
Grant D. Barish, Bart O. Williams
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Crosstalk of the Wnt Signaling Pathway
2010While it is very clear that activation of β-catenin through the canonical Wnt pathway plays a role in a multitude of human cancers, it has also been noted time and time again that activation of β-catenin is observed in tumors without any clear mutation in any of the major components of the pathway or any increase in Wnt signaling.
Michael Thompson +2 more
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Advances in targeting the WNT/β-catenin signaling pathway in cancer
Drug Discovery Today, 2022Avradip Chatterjee +2 more
exaly
[Wnt signaling pathways and osteoarthritis].
Zhongguo gu shang = China journal of orthopaedics and traumatology, 2010The Wnt signaling exists in every kinds of species and regulates a variety of biological processes including cell fate, proliferation and function, immunity, stress, apoptosis and so on. During the researching, Wnt signaling also plays an important role in chondrocyte differentiation and maturation.
Ning-Yang, Gao +5 more
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