Results 271 to 280 of about 200,393 (308)
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Wnt signalling pathway in bladder cancer
Cellular Signalling, 2021Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targeted anticancer drugs and new ...
Guanlin, Wu +7 more
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The Hedgehog and Wnt signalling pathways in cancer
Nature, 2001The Wnt and Hedgehog (Hh) signalling pathways have long been known to direct growth and patterning during embryonic development. Recent evidence also implicates these pathways in the postembryonic regulation of stem-cell number in epithelia such as those of the skin and intestine, which undergo constant renewal.
J, Taipale, P A, Beachy
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The Canonical Wnt Signaling Pathway in Autism
CNS & Neurological Disorders - Drug Targets, 2014Mounting attention is being focused on the canonical Wnt signaling pathway which has been implicated in the pathogenesis of autism in some our and other recent studies. The canonical Wnt pathway is involved in cell proliferation, differentiation and migration, especially during nervous system development. Given its various functions, dysfunction of the
Yinghua, Zhang +3 more
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2008
Abstract The Wnt (wingless) signaling pathway is an important signal transduction pathway that is well conserved across animal phyla. Wnts are a large family of secreted signaling molecules known to play important and diverse roles in developmental processes such as cell fate speci7cation, cell migration, and cell proliferation ...
Lorna S Kategaya +2 more
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Abstract The Wnt (wingless) signaling pathway is an important signal transduction pathway that is well conserved across animal phyla. Wnts are a large family of secreted signaling molecules known to play important and diverse roles in developmental processes such as cell fate speci7cation, cell migration, and cell proliferation ...
Lorna S Kategaya +2 more
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The Wnt signaling pathway and bone metabolism
Current Opinion in Rheumatology, 2007The Wnt signaling pathway has been a major focus of effort in the bone field for the past 5 years. This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism.The Wnt/beta-catenin signaling pathway has been shown to play a major role in bone cell differentiation,
Mark L, Johnson, Mohamed A, Kamel
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Wnt signaling pathway and lung disease
Translational Research, 2008The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility.
Michelle, Van Scoyk +5 more
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An arrow hits the Wnt signaling pathway
Trends in Neurosciences, 2001A recent series of papers in Nature shows that low-density lipoprotein receptor-related protein family members play a role in transduction of Wnt signals. These findings, in addition to other work from the past two years, have important implications for the role of Wnts in neural development.
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The Wnt Signaling Pathway in Bipolar Disorder
The Neuroscientist, 2002The Wnt signaling pathway is a highly conserved pathway critical for proper embryonic development. However, recent evidence suggests that this pathway and one of its key enzymes, glycogen synthase kinase 3β, may play important roles in regulating synaptic plasticity, cell survival, and circadian rhythms in the mature CNS—all of which have been ...
Todd D, Gould, Husseini K, Manji
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The Wnt signaling pathway and rheumatoid arthritis
Autoimmunity Reviews, 2010The Wnt signaling pathways play a key role in cell renewal, and there are two such pathways. In patients with rheumatoid arthritis (RA), the synovial membrane expresses genes such as Wnt and Fz at higher levels than those observed in patients without RA. The Wnt proteins are glycoproteins that bind to receptors of the Fz family on the cell surface. The
Francieli de Sousa, Rabelo +6 more
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Modeling and Verifying WNT Signaling Pathway
Third International Conference on Natural Computation (ICNC 2007), 2007WNT signaling pathway is an important pathway in the development and disease forming of a variety of animals, concerning such processes as hematopoiesis and oncogenesis. In this paper we use quantitative approach to study the canonical pathway of WNT signaling.
Xian Xu, Yanbin Yu
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