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The Wnt signaling pathway and rheumatoid arthritis
Autoimmunity Reviews, 2010The Wnt signaling pathways play a key role in cell renewal, and there are two such pathways. In patients with rheumatoid arthritis (RA), the synovial membrane expresses genes such as Wnt and Fz at higher levels than those observed in patients without RA. The Wnt proteins are glycoproteins that bind to receptors of the Fz family on the cell surface. The
Francieli de Sousa, Rabelo +6 more
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The Wnt/Frizzled GPCR signaling pathway
Biochemistry (Moscow), 2010G protein-coupled receptors (GPCRs) represent the biggest transmembrane receptor family. The Frizzled group of GPCRs is evolutionarily conserved and serves to transduce signals from the Wnt-type lipoglycoprotein growth factors. The Wnt/Frizzled signaling cascades are repeatedly used during animal development and are mostly silent in the adult. Improper
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Wnt signaling: Sox Enters the Wnt Pathway
Science's STKE, 1999The Wnt signaling pathway regulates numerous cellular responses including those that govern axis formation and dorsal-ventral patterning in the developing Xenopus laevis embryo. Upon binding to its receptor Frizzled, a signaling cascade is triggered that results in β-catenin-dependent transcription of Wnt target ...
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The Wnt Signaling Pathway in Retinal Degenerations
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2005The retina is a complex tissue composed of multiple interconnected cell layers, highly specialized for transforming light and color into electrical signals perceived by the brain. Damage or death of the primary light-sensing cells, the photoreceptors, results in devastating effects on vision.
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Advances in targeting the WNT/β-catenin signaling pathway in cancer
Drug Discovery Today, 2022Sayan Paul +2 more
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The research progress of Wnt/β-catenin signaling pathway in colorectal cancer
Clinics and Research in Hepatology and Gastroenterology, 2023Peilin Cui
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Effect of Wnt signaling pathway on wound healing
Biochemical and Biophysical Research Communications, 2009C K Sung, C Y Wang
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