Results 151 to 160 of about 112,529 (303)

Hyperuricaemia in type 1 Gaucher disease: is uric acid a biomarker for disease severity?

open access: yesInternal Medicine Journal, EarlyView.
Abstract Background Elevated serum uric acid (SUA) levels were observed in Gaucher disease type 1 (GD1) patients followed for two decades in northern Israel. There are no previous reports regarding hyperuricaemia in GD1 patients. Aims We aimed to evaluate the frequency of hyperuricaemia in GD1 patients and its correlation to disease severity ...
Zufit Hexner‐Erlichman   +4 more
wiley   +1 more source

Relationship of the intensity of physical performance and sedentary time with uric acid in patients with type 2 diabetes

open access: yesJournal of Diabetes Investigation, EarlyView.
High uric acid (UA) facilitates diabetes progression and is responsible for developing other diseases, such as cardiovascular disease and renal disease. Lifestyle modifications could lower UA levels, but relevant evidence is required in patients with type 2 diabetes.
Jie Li, Ertao Zhang, Zhao Dong, Yan Liu
wiley   +1 more source

Studies on Xanthine Derivatives. II

open access: bronze, 1954
Teiji Ukai   +2 more
openalex   +2 more sources

Xanthine Derivative KMUP‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis

open access: yesJournal of Periodontal Research, EarlyView.
This study reveals that our self‐developed xanthine derivative, KMUP‐3, suppresses osteoclastogenesis, inflammation, and pyroptosis by inhibiting the NLRP3 inflammasome. It also alleviates periodontal bone loss in periodontitis rats, highlighting its potential as a novel therapeutic option for periodontitis.
Shang‐En Huang   +7 more
wiley   +1 more source

RNA elements and their biotechnological applications in plants

open access: yesNew Phytologist, EarlyView.
Summary Engineering of plants for improved traits and efficient heterologous protein production can be achieved by modifying or introducing cis‐ or trans‐acting RNA elements. The function of these elements depends not only on their nucleotide sequence but also on their highly dynamic higher order structures.
Filip Lastovka   +3 more
wiley   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn   +12 more
wiley   +1 more source

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