Results 231 to 240 of about 65,785 (311)

Exploring the role of febuxostat's drug target XOR in erectile dysfunction: insights from human genetics and rat models. [PDF]

Front Med (Lausanne)
Chen Z, Li Y, Meng C, Li X, Liao H, Li X, Zeng Y, Li X, Zhou T, Deng Q.   +9 more
europepmc   +1 more source

Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Untargeted metabolomics reveals a unique cord plasma metabolic landscape versus adult. Age‐declining cord‐specific enriched metabolites are identified as antiaging candidates, with a 5‐compound formula validated in proof‐of‐experiments to extend lifespan and healthspan in human cells and C. elegans.
JiaYu Liu, Shuai Jiang, YanYan Shen, RuiBo Wang, Zhi Jin, YanQing Cao, JinLiang Li, YanHong Liu, Qi Qi, Yue Guo, YunYing Wang, BoYang Xie, JunCheng Li, AiPing Cao, Yao Wang, ChunYan Yan, QiuYing Han, YingJie Zhu, Jing Peng, FangTing Dong, Xin Pan, XinHua He, Tao Zhou, AiLing Li, Kun He, Na Wang, WeiNa Zhang, Qing Xia   +27 more
wiley   +1 more source

Bioactive Components, Untargeted Metabolomics and Bioinformatics of <i>Chaenomeles speciosa</i> Fruit on Uric Acid-Lowering Activity Assessment. [PDF]

Foods
Zhang M, Liu C, Zhang Y, Yuan Z, Chen S, Zhang H, Huang X, Chen L, Mei Z, Ge Y.   +9 more
europepmc   +1 more source

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

British Journal of Pharmacology, Volume 183, Issue 1, Page 40-56, January 2026.
Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue, Sophia K. Heuser, Marla Lindemann, Junjie Li, Masudur Rahman, Malte Kelm, Johannes Stegbauer, Miriam M. Cortese‐Krott   +7 more
wiley   +1 more source

Paradoxical mitochondrial effects of nitric oxide synthase inhibition following oxygen–glucose deprivation–reoxygenation (OGD/R) in endothelial cells and neurons

British Journal of Pharmacology, Volume 183, Issue 2, Page 349-363, January 2026.
Background and Purpose Current dogma in stroke is that neuronal nitric oxide synthase (NOS1) exacerbates ischaemic brain injury, while endothelial nitric oxide synthase (NOS3) is protective. However, oxidative stress from ischaemia–reperfusion and oxygen–glucose deprivation‐reoxygenation (OGD/R) is known to uncouple NOS, leading to increased production
Venkata N. Sure, Siva S. V. P. Sakamuri, Lokanatha Orgunati, Raed Ageeli, Walter L. Murfee, Prasad V. G. Katakam   +5 more
wiley   +1 more source

Toxicological analysis of metabolites in ischemic stroke based on salivary metabolomics. [PDF]

Front Mol Biosci
Liu YS, Long YY, Liu J, Liu YC, Zhang S, Xu YJ, Fu SY, Li H, Liu WH.   +8 more
europepmc   +1 more source

Clinical risk phenotypes in diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes‐Heart Project

Diabetic Medicine, Volume 43, Issue 1, January 2026.
Abstract Aims Diabetes is characterized by clinical heterogeneity. This study aimed to identify different clinical phenotypes of real‐world people with diabetes and to assess their associations with major adverse cardiovascular events (MACEs). Methods From a prospective Polish registry of people with diabetes, hierarchical cluster analysis was ...
Marta Mantovani, Hanna Kwiendacz, Krzysztof Irlik, Tommaso Bucci, Mirela Hendel, Steven H. M. Lam, Bi Huang, Paulina Szromek‐Białek, Monika Niezgoda, Uazman Alam, Giuseppe Boriani, Janusz Gumprecht, Gregory Y. H. Lip, Katarzyna Nabrdalik   +13 more
wiley   +1 more source

Guanine storage vacuoles sequester guanine crystals and serve as nitrogen reserves in <i>Chlamydomonas reinhardtii</i>. [PDF]

Proc Natl Acad Sci U S A
Goodenough U, Roth R, Lee JH.
europepmc   +1 more source

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer

The FEBS Journal, Volume 293, Issue 1, Page 96-112, January 2026.
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz, Víctor Correa‐Pérez, Maribel Rivero, Alejandro Hernández‐Gómez, Marta Martínez‐Júlvez, Rubén M. Buey, Federico Gago, Monica Balsera, Milagros Medina   +8 more
wiley   +1 more source

<i>Limosilactobacillus</i><i>reuteri</i> Urob-7 Alleviates Hyperuricemia by Modulating Uric Acid Metabolism Through Nucleoside Degradation and Xanthine Oxidase Inhibition. [PDF]

Foods
Jing Y, Bai X, Qian H, Wang Y, Hao Y, Zhai Z, Zhang Z, Hao Y.   +7 more
europepmc   +1 more source