Results 51 to 60 of about 89,320 (324)
Synthesis and hypoglycemic activity of 7-n-butyl-3-methyl-8-thioxanthine derivatives
Фармацевтичний журнал, 2018 According to the International Diabetes Federation in 2015 were registered 59.8 million patients with diabetes in Europe. Synthetic drugs are widely applied in addition to a variety of insulins to normalize blood glucose level.
M. I. Romanenko +4 more
doaj +1 more source
Implication of changes in xanthine oxidase activity following hemodialysis
BMC Nephrology, 2023 Background Xanthine oxidase activity has a key role in the development of oxidative stress and progression of cardiovascular diseases. However, the change of xanthine oxidase activity following hemodialysis and its prognostic impact remain uncertain ...
Hayato Fujioka +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Advanced Sensor Research, EarlyView.Magnetic particle spectroscopy and imaging represent promising tools, particularly when combined with manganese‐ferrite nanoparticles as versatile theranostic agents. Adjusting the manganese content allows for simultaneous multi‐color tracer detection and reactive oxygen species sensing via magnetic particle spectroscopy and imaging, creating new ...
Fabian H. L. Starsich +10 more
wiley +1 more source
Temperature and Tautomeric Effects in High-Resolution Oxygen 1s X-ray Photoelectron Spectroscopy of Purines and Pyrimidines [PDF]
J. Chem. Phys. 161, 104303 (2024)Purines and pyrimidines, crucial building blocks in biological systems, have attracted significant interest across molecular physics, biochemistry, pharmacology, and chemistry. Extensive spectroscopies have been employed for characterization, while the temperature and potential tautomeric effects can complicate the interpretation of underlying physics ...
arxiv +1 more source
Xanthine dehydrogenase: An old enzyme with new knowledge and prospects
Bioengineered, 2016 Xanthine dehydrogenase (EC 1.17.1.4, XDH) is a typical and complex molybdenum-containing flavoprotein which has been extensively studied for over 110 years.
Cheng-Hua Wang, Chong Zhang, X. Xing
semanticscholar +1 more source
Advanced Sensor Research, EarlyView.A one‐step electrochemical strategy is utilized to develop a flexible, enzyme‐free biosensor for the sensitive detection of uric acid (UA). The hierarchical cobalt nanostructures synergistically enhance the performance of the biosensor, resulting in a broad detection range of 5 to 700 µM with a sensitivity of 6.75 µA µM−1 cm−2 and a low detection limit
Anju Joshi, Gymama Slaughter
wiley +1 more source
Xanthine oxidase inhibitory activity of Arcangelisia flava
Acta Biochimica Indonesiana, 2022 Background: Hyperuricemia is characterized by elevated levels of uric acid in the blood, produced from its precursor's xanthine and hypoxanthine via xanthine oxidase.
Fatmawati +5 more
doaj +1 more source
Advanced Science, EarlyView.The research findings indicate that dimethyl itaconate (DI) alleviates Escherichia coli (E. coli) induced endometritis by modulating the gut microbiota and enriching the abundance of norank_f_Muribaculaceae, thereby increasing the production of guanosine.
Yuhang He +6 more
wiley +1 more source
Effect of oxidative stress on the activity of human osteoblastic MG63 cells
口腔疾病防治, 2017 Objective To investigate the morphology and proliferation viability in oxidative stress induced damage in human MG63 cells. Methods The MG63 cells were treated with superoxide anion (O2.⁃) produced by different con⁃ centrations of xanthine/xanthine ...
WANG Qiong
doaj +1 more source