Results 61 to 70 of about 169,173 (169)

Dapagliflozin Alters Plasma Metabolome in Patients With Type 1 Diabetes During Ketosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Use of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 1 diabetes (T1D) is limited by increased risk of ketoacidosis. We aimed to determine metabolic pathways affected by SGLT2i treatment in adults with T1D during ketosis induced by insulin withdrawal.
Rosa Yang, Kevin Cho, Max C. Petersen, Kai E. Jones, Gary J. Patti, Janet B. McGill, Samantha A. DiGruccio   +6 more
wiley   +1 more source

A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam, Marta Meneghello, Chloé Guendon, Jade Chargelègue, Andrea Fasano, Aurore Jacq‐Bailly, Christophe Léger, Vincent Fourmond   +7 more
wiley   +2 more sources

Disrupted NAD(P) Metabolism and Xanthine Dehydrogenase in a Stress-Induced Rat Model of Depression: NMR Metabolomics Insights

Metabolites
Background: Clinical findings have shown a negative correlation between the severity of depressive symptoms and serum uric acid levels in men, yet the role of metabolic regulation in the pathophysiology of depression remains largely unknown.
Songjiao Chen, Jumeng Wei, Yongchi Wang, Yidan Yao, Haibo Wang, Jie Peng, Jinquan Li   +6 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

The Cytosolic Iron–Sulfur Cluster Assembly Targeting Complex Is Hijacked by Magnaporthe Effector AvrPi9 to Suppress Rice Resistance

Plant Biotechnology Journal, EarlyView.
ABSTRACT The cytosolic iron–sulfur (Fe‐S) cluster assembly (CIA) targeting complex mediates the maturation of cytosolic and nuclear Fe‐S proteins and governs core eukaryotic cellular processes. However, whether this complex contributes to plant disease resistance remains unclear.
Huanbin Shi, Zhiquan Liu, Ying Zhang, Runjing Li, Zhizhen Fu, Ya Chen, Hui Wen, Liang Cai, Zhengting Chen, Jiehua Qiu, Yanjun Kou   +10 more
wiley   +1 more source

Distribution of xanthine oxidase and xanthine dehydrogenase specificity types among bacteria [PDF]

Journal of Bacteriology, 1977
A diverse collection of xanthine-metabolizing bacteria was examined for xanthine-, 1-methylxanthine-, and 3-methylxanthine-oxidizing activity. Both particulate and soluble fractions of extracts from aerobically grown gram-negative bacteria exhibited oxidation of all three substrates; however, when facultative gram-negative bacteria were grown ...
C A, Woolfolk, J S, Downard
openaire   +2 more sources

Studies on milk xanthine dehydrogenase.

, 1994
Milk xanthine oxidase (MXO) is a metalloflavoprotein which converts xanthine to urate. The dimeric enzyme contains one FAD, two (2Fe-2S) centers, and one molybdopterin cofactor per subunit. Xanthine is oxidized to urate by the molybdopterin, and reducing
Hunt, Jennifer Audrey
core   +3 more sources

First case of hereditary xanthinuria in a Moroccan family

PAMJ Clinical Medicine, 2019
The xanthinuria is a rare hereditary autosomal recessive disease. It is related to xanthine oxidase deficiency also known as xanthine dehydrogenase, an enzyme involved in the metabolism of purine bases.
Aicha Ezoubeiri, Asma Labaali, Naima Fdil, Jean-François Benoist, Laila Chabaa   +4 more
doaj   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn, Fabian B. Haas, Benjamin G. Chavez, Bernd H. Dreyer, Erik V. Reiss, Anne Ziplys, Heiko Weichert, Saskia Hiltemann, José M. Ugalde, Andreas J. Meyer, John C. D'Auria, Stefan A. Rensing, Jos H. M. Schippers   +12 more
wiley   +1 more source

Induction of the Conversion of Xanthine Dehydrogenase to Oxidase in Rabbit Liver by Cu2+, Zn2+ and Selenium Ions

, 1994
Effects of Cu2+, Zn2+, Fe2+ and selenium ions on the conversion of xanthine dehydrogenase to oxidase in rabbit liver were examined. Under basal conditions, xanthine oxidase activity represented only 16% of the total xanthine oxidase plus dehydrogenase ...
Maki Yasuda, Mimi Iwai, Kenjiro Fujimoto, Hiroko Nishida, Satoru Sakuma, Tadashi Fujita, Yohko Fujimoto   +6 more
core   +1 more source