Results 81 to 90 of about 17,774 (187)

The changing epidemiology of human type 2 diabetes–associated atherosclerosis: Pathophysiological mechanisms and emerging treatment possibilities

Journal of Internal Medicine, Volume 300, Issue 2, Page 131-152, August 2026.
Abstract Type 2 diabetes (T2D) is a major global health concern strongly associated with atherosclerosis and subsequent macrovascular complications. These complications are the leading cause of death among T2D patients. Despite a decline in cardiovascular events over the last decade, individuals with T2D still have an approximately doubled risk ...
Dania Al‐Sharify, Jiangming Sun, Andreas Edsfeldt   +2 more
wiley   +1 more source

Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function. [PDF]

Intern Med, 2022
Miyazaki S, Hamada T, Sugihara S, Mizuta E, Endo Y, Ohtahara A, Komatsu K, Kuwabara M, Fukuuchi T, Kaneko K, Ichida K, Ogino K, Ninomiya H, Yamamoto K, Nakamura T, Hisatome I.   +15 more
europepmc   +1 more source

Range‐Wide Genetic Population Structure and Environmental Adaptation in the Eastern Oyster (Crassostrea virginica) Provides Insight for Aquaculture

Molecular Ecology, Volume 35, Issue 15, August 2026.
ABSTRACT Selective breeding in aquaculture is necessary to establish food security and meet demand for sustainably produced protein. An informed selective breeding program requires understanding how population structure, environmental adaptation, and human activities shape natural genetic variation in wild conspecifics.
Madeline G. Eppley, Kiran Bajaj, Camille Rumberger, Elisabeth Leung, Nicole Mongillo, Jessica Small, Katie E. Lotterhos   +6 more
wiley   +1 more source

Xanthine dehydrogenase rewires metabolism and the survival of nutrient deprived lung adenocarcinoma cells by facilitating UPR and autophagic degradation. [PDF]

Int J Biol Sci, 2023
Chen MM, Guo W, Chen SM, Guo XZ, Xu L, Ma XY, Wang YX, Xie C, Meng LH.   +8 more
europepmc   +1 more source

Effects of Cherry in Take Versus Allopurinol on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Hepatic Xanthine Oxidase/Xanthine Dehydrogenase Activity in Hyperuricemic Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
<p><strong>Background and Objectives</strong></p><p>Prevention and treatment of hyperuricemia are based on control of uric acid levels.
F Haidari
doaj  

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4823-4843, August 2026.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source

Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson's Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2. [PDF]

J Dev Biol, 2023
Starr LA, McKay LE, Peter KN, Seyfarth LM, Berkowitz LA, Caldwell KA, Caldwell GA.   +6 more
europepmc   +1 more source

Comparative characteristics of blood xanthine oxidoreductase profiles in discoid and systemic lupus erythematosus

Сибирский научный медицинский журнал
Discoid (DLE) and systemic lupus erythematosus (SLE) are chronic inflammatory diseases of the connective tissue. Along with pathogenetic features, they have common characteristics. Immune disorders and oxidative stress are involved in pathogenesis of DLE
E. E. Mozgovaya, S. A. Bedina, A. S. Trofimenko, S. S. Spitsina, M. A. Mamus, I. A. Zborovskaya   +5 more
doaj   +1 more source

A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow’s milk

Journal of Extracellular Vesicles, 2017
MicroRNAs are small gene-regulatory RNAs that are found in various biological fluids, including milk, where they are often contained inside extracellular vesicles (EVs), like exosomes.
Abderrahim Benmoussa, Sophia Ly, Si Ting Shan, Jonathan Laugier, Eric Boilard, Caroline Gilbert, Patrick Provost   +6 more
doaj   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source