Results 71 to 80 of about 17,774 (187)

Analysis of molecular mechanism for acceleration of polyembryony using gene functional annotation pipeline in Copidosoma floridanum

BMC Genomics, 2020
Background Polyembryony is defined as the formation of several embryos from a single egg. This phenomenon can occur in humans, armadillo, and some endoparasitoid insects.
Takuma Sakamoto, Maaya Nishiko, Hidemasa Bono, Takeru Nakazato, Jin Yoshimura, Hiroko Tabunoki, Kikuo Iwabuchi   +6 more
doaj   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

A putative xanthine dehydrogenase is critical for Borrelia burgdorferi survival in ticks and mice. [PDF]

Microbiology (Reading), 2023
Phelan JP, Bourgeois JS, McCarthy JE, Hu LT.   +3 more
europepmc   +1 more source

Integrated Transcriptomics and Metabolomics Analyses Provide Insights into Heat Resistance in Passion Fruit (P. edulis f. flavicarpa)

Horticulturae
Passion fruit (Passiflora edulis) is an economically important fruit worldwide. However, heat stress severely threatens its production, particularly in tropical and subtropical regions.
Lin-Hua Chen, Jiong Dong, Bing-Liang Fan, Yongcai Huang, Liu Yang, Wenguo Cai, Ling-Ling Chen   +6 more
doaj   +1 more source

Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans. [PDF]

Cells, 2023
Thies JL, Willicott K, Craig ML, Greene MR, DuGay CN, Caldwell GA, Caldwell KA.   +6 more
europepmc   +1 more source

Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells

Frontiers in Immunology
BackgroundInterleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal mediator of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, critically involved in innate immune activation and pro-inflammatory cytokine production ...
Sadiq Umar, Huan T. Chang, Huan T. Chang, Mark Maienschein-Cline, Sriram Ravindran   +4 more
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Mutation of OsSAC3, Encoding the Xanthine Dehydrogenase, Caused Early Senescence in Rice. [PDF]

Int J Mol Sci, 2022
Xie Z, Zhao B, Zhang M, Sang X, Zhao F, Feng P, He G, Zhu X.   +7 more
europepmc   +1 more source

A guaB Mutant Strain of Rhizobium tropici CIAT899 Pleiotropically Defective in Thermal Tolerance and Symbiosis

Molecular Plant-Microbe Interactions, 2000
Rhizobium tropici strain CIAT899 displays a high intrinsic thermal tolerance, and had been used in this work to study the molecular basis of bacterial responses to high temperature. We generated a collection of R.
Pablo M. Riccillo, Monica M. Collavino, Daniel H. Grasso, Reg England, Frans J. de Bruijn, O. Mario Aguilar   +5 more
doaj   +1 more source

Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6561-6575, August 2026.
ABSTRACT Aims Similar to blood, saliva contains a broad range of biomarkers and may offer a non‐invasive, repeatable specimen for endocrine and metabolic assessment. This review aims to synthesise and evaluate recent advances in the clinical translation of salivary biomarkers, while providing a critical assessment of the diagnostic reliability and ...
Chuyan Yu, Jiaying Ni, Qian Dou, Hang Su, Ziyi Zhang, Xiaojing Ma, Qing Dai, Jian Zhou   +7 more
wiley   +1 more source